Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361960120> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4361960120 abstract "<div>AbstractPurpose:<p>Immune dysregulation is described in multiple myeloma. While preclinical models suggest a role for altered T-cell immunity in disease progression, the contribution of immune dysfunction to clinical outcomes remains unclear. We aimed to characterize marrow-infiltrating T cells in newly diagnosed patients and explore associations with outcomes of first-line therapy.</p>Experimental Design:<p>We undertook detailed characterization of T cells from bone marrow (BM) samples, focusing on immune checkpoints and features of immune dysfunction, correlating with clinical features and progression-free survival.</p>Results:<p>We found that patients with multiple myeloma had greater abundance of BM regulatory T cells (Tregs) which, in turn, expressed higher levels of the activation marker CD25 compared with healthy donors. Patients with higher frequencies of Tregs had shorter PFS and a distinct Treg immune checkpoint profile (increased PD-1, LAG-3) compared with patients with lower frequencies of Tregs. Analysis of CD4 and CD8 effectors revealed that low CD4effector (CD4<sup>eff</sup>):Treg ratio and increased frequency of PD-1–expressing CD4<sup>eff</sup> cells were independent predictors of early relapse over and above conventional risk factors, such as genetic risk and depth of response. <i>Ex vivo</i> functional analysis and RNA sequencing revealed that CD4 and CD8 cells from patients with greater abundance of CD4<sup>eff</sup>PD-1<sup>+</sup> cells displayed transcriptional and secretory features of dysfunction.</p>Conclusions:<p>BM-infiltrating T-cell subsets, specifically Tregs and PD-1–expressing CD4 effectors, negatively influence clinical outcomes in newly diagnosed patients. Pending confirmation in larger cohorts and further mechanistic work, these immune parameters may inform new risk models, and present potential targets for immunotherapeutic strategies.</p></div>" @default.
- W4361960120 created "2023-04-05" @default.
- W4361960120 creator A5002184046 @default.
- W4361960120 creator A5011340913 @default.
- W4361960120 creator A5012617779 @default.
- W4361960120 creator A5017654709 @default.
- W4361960120 creator A5018576774 @default.
- W4361960120 creator A5021140442 @default.
- W4361960120 creator A5022750427 @default.
- W4361960120 creator A5030543123 @default.
- W4361960120 creator A5033393201 @default.
- W4361960120 creator A5037780654 @default.
- W4361960120 creator A5038896136 @default.
- W4361960120 creator A5039646850 @default.
- W4361960120 creator A5045712447 @default.
- W4361960120 creator A5048365807 @default.
- W4361960120 creator A5054600574 @default.
- W4361960120 creator A5068293508 @default.
- W4361960120 creator A5071244458 @default.
- W4361960120 creator A5071957752 @default.
- W4361960120 creator A5089455737 @default.
- W4361960120 date "2023-03-31" @default.
- W4361960120 modified "2023-10-18" @default.
- W4361960120 title "Data from Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4<sup>+</sup>PD-1<sup>+</sup> Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma" @default.
- W4361960120 doi "https://doi.org/10.1158/1078-0432.c.6528762" @default.
- W4361960120 hasPublicationYear "2023" @default.
- W4361960120 type Work @default.
- W4361960120 citedByCount "0" @default.
- W4361960120 crossrefType "posted-content" @default.
- W4361960120 hasAuthorship W4361960120A5002184046 @default.
- W4361960120 hasAuthorship W4361960120A5011340913 @default.
- W4361960120 hasAuthorship W4361960120A5012617779 @default.
- W4361960120 hasAuthorship W4361960120A5017654709 @default.
- W4361960120 hasAuthorship W4361960120A5018576774 @default.
- W4361960120 hasAuthorship W4361960120A5021140442 @default.
- W4361960120 hasAuthorship W4361960120A5022750427 @default.
- W4361960120 hasAuthorship W4361960120A5030543123 @default.
- W4361960120 hasAuthorship W4361960120A5033393201 @default.
- W4361960120 hasAuthorship W4361960120A5037780654 @default.
- W4361960120 hasAuthorship W4361960120A5038896136 @default.
- W4361960120 hasAuthorship W4361960120A5039646850 @default.
- W4361960120 hasAuthorship W4361960120A5045712447 @default.
- W4361960120 hasAuthorship W4361960120A5048365807 @default.
- W4361960120 hasAuthorship W4361960120A5054600574 @default.
- W4361960120 hasAuthorship W4361960120A5068293508 @default.
- W4361960120 hasAuthorship W4361960120A5071244458 @default.
- W4361960120 hasAuthorship W4361960120A5071957752 @default.
- W4361960120 hasAuthorship W4361960120A5089455737 @default.
- W4361960120 hasBestOaLocation W43619601202 @default.
- W4361960120 hasConcept C126322002 @default.
- W4361960120 hasConcept C153911025 @default.
- W4361960120 hasConcept C167672396 @default.
- W4361960120 hasConcept C203014093 @default.
- W4361960120 hasConcept C2776090121 @default.
- W4361960120 hasConcept C2779727006 @default.
- W4361960120 hasConcept C2780007613 @default.
- W4361960120 hasConcept C502942594 @default.
- W4361960120 hasConcept C71924100 @default.
- W4361960120 hasConcept C79484868 @default.
- W4361960120 hasConcept C86803240 @default.
- W4361960120 hasConcept C8891405 @default.
- W4361960120 hasConceptScore W4361960120C126322002 @default.
- W4361960120 hasConceptScore W4361960120C153911025 @default.
- W4361960120 hasConceptScore W4361960120C167672396 @default.
- W4361960120 hasConceptScore W4361960120C203014093 @default.
- W4361960120 hasConceptScore W4361960120C2776090121 @default.
- W4361960120 hasConceptScore W4361960120C2779727006 @default.
- W4361960120 hasConceptScore W4361960120C2780007613 @default.
- W4361960120 hasConceptScore W4361960120C502942594 @default.
- W4361960120 hasConceptScore W4361960120C71924100 @default.
- W4361960120 hasConceptScore W4361960120C79484868 @default.
- W4361960120 hasConceptScore W4361960120C86803240 @default.
- W4361960120 hasConceptScore W4361960120C8891405 @default.
- W4361960120 hasLocation W43619601201 @default.
- W4361960120 hasLocation W43619601202 @default.
- W4361960120 hasOpenAccess W4361960120 @default.
- W4361960120 hasPrimaryLocation W43619601201 @default.
- W4361960120 hasRelatedWork W1557803273 @default.
- W4361960120 hasRelatedWork W1968118037 @default.
- W4361960120 hasRelatedWork W2138864047 @default.
- W4361960120 hasRelatedWork W2366649094 @default.
- W4361960120 hasRelatedWork W2384344522 @default.
- W4361960120 hasRelatedWork W2767749856 @default.
- W4361960120 hasRelatedWork W2995822774 @default.
- W4361960120 hasRelatedWork W3214820661 @default.
- W4361960120 hasRelatedWork W4327734445 @default.
- W4361960120 hasRelatedWork W4366173980 @default.
- W4361960120 isParatext "false" @default.
- W4361960120 isRetracted "false" @default.
- W4361960120 workType "article" @default.