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- W4361960130 abstract "<div>Abstract<p><b>Purpose:</b> To develop an adaptable gene-based vector that will confer immune cell specificity to various cancer types.</p><p><b>Experimental Design:</b> Human and mouse T cells were genetically engineered to express a chimeric antigen receptor (CAR) that binds a fluorescein isothiocyanate (FITC) molecule, termed anti-FITC CAR T cells. Various antibodies (Ab) currently in clinical use including cetuximab (Ctx), trastuzumab (Her2), and rituximab (Rtx) were conjugated with FITC and tested for their ability to bind tumor cells, activate T cells, and induce antitumor effects <i>in vitro</i> and <i>in vivo</i>.</p><p><b>Results:</b> Anti-FITC CAR T cells recognize various cancer types when bound with FITC-labeled Abs resulting in efficient target lysis, T-cell proliferation, and cytokine/chemokine production. The treatment of immunocompromised mice with human anti-FITC CAR T cells plus FITC-labeled cetuximab (FITC-Ctx) delayed the growth of colon cancer but unexpectedly led to the outgrowth of EGF receptor (EGFR)-negative tumor cells. On the other hand, in a human pancreatic cancer cell line with uniform EGFR expression, anti-FITC CAR T cells plus FITC-Ctx eradicated preestablished late-stage tumors. In immunocompetent mice, anti-FITC CAR T cells exhibited potent antitumor activity against syngeneic mouse breast cancer expressing Her2 and B-cell lymphoma expressing CD20 by combining with FITC-Her2 and FITC-Rtx, respectively. In addition, the activity of anti-FITC CAR T cells could be attenuated by subsequent injections of nonspecific FITC-IgG.</p><p><b>Conclusion:</b> These studies highlight an applicability of anti-tag CAR technology to treat patients with different types of cancers and a possibility to regulate CAR T-cell functions with competing FITC molecules. <i>Clin Cancer Res; 18(23); 6436–45. ©2012 AACR</i>.</p></div>" @default.
- W4361960130 created "2023-04-05" @default.
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- W4361960130 date "2023-03-31" @default.
- W4361960130 modified "2023-09-27" @default.
- W4361960130 title "Data from Redirecting Gene-Modified T Cells toward Various Cancer Types Using Tagged Antibodies" @default.
- W4361960130 doi "https://doi.org/10.1158/1078-0432.c.6523142" @default.
- W4361960130 hasPublicationYear "2023" @default.
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