FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361960908> ?p ?o ?g. }

• W4361960908 abstract "<div>Abstract<p><b>Purpose:</b> Germ line polymorphisms may confer susceptibility to lung cancer in never smokers, but studies in the United States have been limited by the low number of cases seen at single institutions. We hypothesized that we could use the Internet to bolster the accrual of appropriate patients.</p><p><b>Experimental Design:</b> We established an Internet-based protocol to collect blood and information from patients throughout the United States. To illustrate the power of this approach, we used these samples, plus additional cases and age-matched controls from the Memorial Sloan-Kettering Cancer Center (New York, NY) and the Aichi Cancer Center (Nagoya, Japan), to analyze germ line DNA for genetic variants reportedly associated with lung cancer susceptibility. The genotypes for the polymorphisms rs763317 (intron 1) and T790M (exon 20) in the <i>EGFR</i> gene were determined by direct sequencing, and <i>CHRNA3</i> nicotinic acetylcholine receptor single nucleotide polymorphisms (rs8034191 and rs1051730) were genotyped as part of a pilot genome-wide association study.</p><p><b>Results:</b> We successfully analyzed germ line DNA from 369 cases, including 45 obtained via the Internet, and 342 controls. A germ line <i>EGFR</i> T790M variant was identified in 2 of the 369 cases (0.54%; 95% confidence interval, 0.21-1.29%), and in none of the 292 controls (<i>P</i> = 0.21). No difference was observed in <i>EGFR</i> rs763317 frequency between cases and controls. Similarly, neither <i>CHRNA3</i> rs8034191 nor rs1051730 were associated with lung cancer risk.</p><p><b>Conclusions:</b> The Internet provides a way to recruit patients throughout the country for minimal risk studies. This approach could be used to facilitate studies of germ line polymorphisms in specific groups of patients with cancer. Clin Cancer Res; 16(2); 755–63</p></div>" @default.
• W4361960908 created "2023-04-05" @default.
• W4361960908 creator A5004887244 @default.
• W4361960908 creator A5024299802 @default.
• W4361960908 creator A5035120516 @default.
• W4361960908 creator A5035795621 @default.
• W4361960908 creator A5039791495 @default.
• W4361960908 creator A5045514288 @default.
• W4361960908 creator A5046345178 @default.
• W4361960908 creator A5051132319 @default.
• W4361960908 creator A5052336062 @default.
• W4361960908 creator A5060033755 @default.
• W4361960908 creator A5062616992 @default.
• W4361960908 creator A5062667375 @default.
• W4361960908 creator A5065067520 @default.
• W4361960908 creator A5065196329 @default.
• W4361960908 creator A5066730612 @default.
• W4361960908 creator A5074616394 @default.
• W4361960908 creator A5090329560 @default.
• W4361960908 date "2023-03-31" @default.
• W4361960908 modified "2023-10-16" @default.
• W4361960908 title "Data from Analysis of Genetic Variants in Never-Smokers with Lung Cancer Facilitated by an Internet-Based Blood Collection Protocol: A Preliminary Report" @default.
• W4361960908 doi "https://doi.org/10.1158/1078-0432.c.6519293" @default.
• W4361960908 hasPublicationYear "2023" @default.
• W4361960908 type Work @default.
• W4361960908 citedByCount "0" @default.
• W4361960908 crossrefType "posted-content" @default.
• W4361960908 hasAuthorship W4361960908A5004887244 @default.
• W4361960908 hasAuthorship W4361960908A5024299802 @default.
• W4361960908 hasAuthorship W4361960908A5035120516 @default.
• W4361960908 hasAuthorship W4361960908A5035795621 @default.
• W4361960908 hasAuthorship W4361960908A5039791495 @default.
• W4361960908 hasAuthorship W4361960908A5045514288 @default.
• W4361960908 hasAuthorship W4361960908A5046345178 @default.
• W4361960908 hasAuthorship W4361960908A5051132319 @default.
• W4361960908 hasAuthorship W4361960908A5052336062 @default.
• W4361960908 hasAuthorship W4361960908A5060033755 @default.
• W4361960908 hasAuthorship W4361960908A5062616992 @default.
• W4361960908 hasAuthorship W4361960908A5062667375 @default.
• W4361960908 hasAuthorship W4361960908A5065067520 @default.
• W4361960908 hasAuthorship W4361960908A5065196329 @default.
• W4361960908 hasAuthorship W4361960908A5066730612 @default.
• W4361960908 hasAuthorship W4361960908A5074616394 @default.
• W4361960908 hasAuthorship W4361960908A5090329560 @default.
• W4361960908 hasConcept C104317684 @default.
• W4361960908 hasConcept C121608353 @default.
• W4361960908 hasConcept C126322002 @default.
• W4361960908 hasConcept C135763542 @default.
• W4361960908 hasConcept C143998085 @default.
• W4361960908 hasConcept C153209595 @default.
• W4361960908 hasConcept C2776256026 @default.
• W4361960908 hasConcept C54355233 @default.
• W4361960908 hasConcept C71924100 @default.
• W4361960908 hasConcept C86803240 @default.
• W4361960908 hasConceptScore W4361960908C104317684 @default.
• W4361960908 hasConceptScore W4361960908C121608353 @default.
• W4361960908 hasConceptScore W4361960908C126322002 @default.
• W4361960908 hasConceptScore W4361960908C135763542 @default.
• W4361960908 hasConceptScore W4361960908C143998085 @default.
• W4361960908 hasConceptScore W4361960908C153209595 @default.
• W4361960908 hasConceptScore W4361960908C2776256026 @default.
• W4361960908 hasConceptScore W4361960908C54355233 @default.
• W4361960908 hasConceptScore W4361960908C71924100 @default.
• W4361960908 hasConceptScore W4361960908C86803240 @default.
• W4361960908 hasLocation W43619609081 @default.
• W4361960908 hasOpenAccess W4361960908 @default.
• W4361960908 hasPrimaryLocation W43619609081 @default.
• W4361960908 hasRelatedWork W1663907732 @default.
• W4361960908 hasRelatedWork W2084956593 @default.
• W4361960908 hasRelatedWork W2348657758 @default.
• W4361960908 hasRelatedWork W2369766501 @default.
• W4361960908 hasRelatedWork W2374492847 @default.
• W4361960908 hasRelatedWork W2380954950 @default.
• W4361960908 hasRelatedWork W2382951635 @default.
• W4361960908 hasRelatedWork W2383962679 @default.
• W4361960908 hasRelatedWork W3030123494 @default.
• W4361960908 hasRelatedWork W3109192623 @default.
• W4361960908 isParatext "false" @default.
• W4361960908 isRetracted "false" @default.
• W4361960908 workType "article" @default.