FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361961036> ?p ?o ?g. }

• W4361961036 abstract "<div>Abstract<p><b>Purpose:</b> VEGF receptor 2 (VEGFR2) inhibitors, as efficient antiangiogenesis agents, have been applied in the cancer treatment. However, currently most of these anticancer drugs suffer some adverse effects. Discovery of novel VEGFR2 inhibitors as anticancer drug candidates is still needed.</p><p><b>Experimental Design:</b> In this investigation, we adopted a restricted <i>de novo</i> design method to design VEGFR2 inhibitors. We selected the most potent compound SKLB1002 and analyzed its inhibitory effects on human umbilical vein endothelial cells (HUVEC) <i>in vitro</i>. Tumor xenografts in zebrafish and athymic mice were used to examine the <i>in vivo</i> activity of SKLB1002.</p><p><b>Results:</b> The use of the restricted <i>de novo</i> design method indeed led to a new potent VEGFR2 inhibitor, SKLB1002, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. Western blot analysis was conducted, which indicated that SKLB1002 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal-regulated kinase, focal adhesion kinase, and Src. <i>In vivo</i> zebrafish model experiments showed that SKLB1002 remarkably blocked the formation of intersegmental vessels in zebrafish embryos. It was further found to inhibit a new microvasculature in zebrafish embryos induced by inoculated tumor cells. Finally, compared with the solvent control, administration of 100 mg/kg/d SKLB1002 reached more than 60% inhibition against human tumor xenografts in athymic mice. The antiangiogenic effect was indicated by CD31 immunohistochemical staining and alginate-encapsulated tumor cell assay.</p><p><b>Conclusions:</b> Our findings suggest that SKLB1002 inhibits angiogenesis and may be a potential drug candidate in anticancer therapy. <i>Clin Cancer Res; 17(13); 4439–50. ©2011 AACR</i>.</p></div>" @default.
• W4361961036 created "2023-04-05" @default.
• W4361961036 creator A5002744113 @default.
• W4361961036 creator A5004289873 @default.
• W4361961036 creator A5007114408 @default.
• W4361961036 creator A5007867139 @default.
• W4361961036 creator A5012669091 @default.
• W4361961036 creator A5028675439 @default.
• W4361961036 creator A5032483419 @default.
• W4361961036 creator A5032702389 @default.
• W4361961036 creator A5033098447 @default.
• W4361961036 creator A5034823522 @default.
• W4361961036 creator A5035528148 @default.
• W4361961036 creator A5038067527 @default.
• W4361961036 creator A5038112821 @default.
• W4361961036 creator A5039938000 @default.
• W4361961036 creator A5042467158 @default.
• W4361961036 creator A5046597133 @default.
• W4361961036 creator A5048800110 @default.
• W4361961036 creator A5049692788 @default.
• W4361961036 creator A5058339166 @default.
• W4361961036 creator A5069425796 @default.
• W4361961036 creator A5075125362 @default.
• W4361961036 creator A5078143614 @default.
• W4361961036 creator A5080400020 @default.
• W4361961036 creator A5090403310 @default.
• W4361961036 date "2023-03-31" @default.
• W4361961036 modified "2023-09-26" @default.
• W4361961036 title "Data from SKLB1002, a Novel Potent Inhibitor of VEGF Receptor 2 Signaling, Inhibits Angiogenesis and Tumor Growth <i>In Vivo</i>" @default.
• W4361961036 doi "https://doi.org/10.1158/1078-0432.c.6518515" @default.
• W4361961036 hasPublicationYear "2023" @default.
• W4361961036 type Work @default.
• W4361961036 citedByCount "0" @default.
• W4361961036 crossrefType "posted-content" @default.
• W4361961036 hasAuthorship W4361961036A5002744113 @default.
• W4361961036 hasAuthorship W4361961036A5004289873 @default.
• W4361961036 hasAuthorship W4361961036A5007114408 @default.
• W4361961036 hasAuthorship W4361961036A5007867139 @default.
• W4361961036 hasAuthorship W4361961036A5012669091 @default.
• W4361961036 hasAuthorship W4361961036A5028675439 @default.
• W4361961036 hasAuthorship W4361961036A5032483419 @default.
• W4361961036 hasAuthorship W4361961036A5032702389 @default.
• W4361961036 hasAuthorship W4361961036A5033098447 @default.
• W4361961036 hasAuthorship W4361961036A5034823522 @default.
• W4361961036 hasAuthorship W4361961036A5035528148 @default.
• W4361961036 hasAuthorship W4361961036A5038067527 @default.
• W4361961036 hasAuthorship W4361961036A5038112821 @default.
• W4361961036 hasAuthorship W4361961036A5039938000 @default.
• W4361961036 hasAuthorship W4361961036A5042467158 @default.
• W4361961036 hasAuthorship W4361961036A5046597133 @default.
• W4361961036 hasAuthorship W4361961036A5048800110 @default.
• W4361961036 hasAuthorship W4361961036A5049692788 @default.
• W4361961036 hasAuthorship W4361961036A5058339166 @default.
• W4361961036 hasAuthorship W4361961036A5069425796 @default.
• W4361961036 hasAuthorship W4361961036A5075125362 @default.
• W4361961036 hasAuthorship W4361961036A5078143614 @default.
• W4361961036 hasAuthorship W4361961036A5080400020 @default.
• W4361961036 hasAuthorship W4361961036A5090403310 @default.
• W4361961036 hasConcept C104317684 @default.
• W4361961036 hasConcept C150903083 @default.
• W4361961036 hasConcept C153911025 @default.
• W4361961036 hasConcept C184235292 @default.
• W4361961036 hasConcept C185592680 @default.
• W4361961036 hasConcept C207001950 @default.
• W4361961036 hasConcept C2776056115 @default.
• W4361961036 hasConcept C2776878037 @default.
• W4361961036 hasConcept C2780394083 @default.
• W4361961036 hasConcept C502942594 @default.
• W4361961036 hasConcept C55493867 @default.
• W4361961036 hasConcept C86803240 @default.
• W4361961036 hasConcept C95444343 @default.
• W4361961036 hasConcept C98274493 @default.
• W4361961036 hasConceptScore W4361961036C104317684 @default.
• W4361961036 hasConceptScore W4361961036C150903083 @default.
• W4361961036 hasConceptScore W4361961036C153911025 @default.
• W4361961036 hasConceptScore W4361961036C184235292 @default.
• W4361961036 hasConceptScore W4361961036C185592680 @default.
• W4361961036 hasConceptScore W4361961036C207001950 @default.
• W4361961036 hasConceptScore W4361961036C2776056115 @default.
• W4361961036 hasConceptScore W4361961036C2776878037 @default.
• W4361961036 hasConceptScore W4361961036C2780394083 @default.
• W4361961036 hasConceptScore W4361961036C502942594 @default.
• W4361961036 hasConceptScore W4361961036C55493867 @default.
• W4361961036 hasConceptScore W4361961036C86803240 @default.
• W4361961036 hasConceptScore W4361961036C95444343 @default.
• W4361961036 hasConceptScore W4361961036C98274493 @default.
• W4361961036 hasLocation W43619610361 @default.
• W4361961036 hasOpenAccess W4361961036 @default.
• W4361961036 hasPrimaryLocation W43619610361 @default.
• W4361961036 hasRelatedWork W1487477247 @default.
• W4361961036 hasRelatedWork W1533466347 @default.
• W4361961036 hasRelatedWork W1842687350 @default.
• W4361961036 hasRelatedWork W1932139919 @default.
• W4361961036 hasRelatedWork W2013734711 @default.
• W4361961036 hasRelatedWork W2066936999 @default.
• W4361961036 hasRelatedWork W2349030099 @default.
• W4361961036 hasRelatedWork W2388916454 @default.
• W4361961036 hasRelatedWork W4293047621 @default.
• W4361961036 hasRelatedWork W4324378713 @default.
• W4361961036 isParatext "false" @default.

• next