FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361961370> ?p ?o ?g. }

• W4361961370 abstract "<div>Abstract<p><b>Purpose:</b> CXCR4 plays an important role in the retention of stem cells within the bone marrow. BKT140 (4F-benzoyl-TN14003) is a 14-residue bio stable synthetic peptide, which binds CXCR4 with a greater affinity compared with plerixafor (4 vs. 84 nmol/L). Studies in mice demonstrated the efficient and superior mobilization and transplantation of stem cells collected with GCSF-BKT140, compared with those obtained when using stem cells obtained with each one of these mobilizing agent alone. These results have served as a platform for the present clinical phase I study.</p><p><b>Experimental Design:</b> Eighteen patients with multiple myeloma who were preparing for their first autologous stem cell transplantation were included. Patients received a standard multiple myeloma mobilization regimen, consisting of 3 to 4 g/m² cyclophosphamide (day 0), followed by granulocyte colony—stimulating factor (G-CSF) at 5 μg/kg/d starting on day 5 and administered between 8 and 10 pm until the end of stem cell collection. A single injection of BKT140 (0.006, 0.03, 0.1, 0.3, and 0.9 mg/kg) was administered subcutaneously on day 10 in the early morning, followed by G-CSF 12 hours later.</p><p><b>Results:</b> BKT140 was well tolerated at all concentrations, and none of the patients developed grade 3 and 4 toxicity. A single administration of BKT140 at the highest dose, 0.9 mg/kg, resulted in a robust mobilization and collection of CD34⁺ cells (20.6 ± 6.9 × 10⁶/kg), which were obtained through a single apheresis. All transplanted patients received ∼5.3 × 10⁶ CD34⁺ cells/kg, which rapidly engrafted (<i>n</i> = 17). The median time to neutrophil and platelet recovery was 12 and 14 days, respectively, at the highest dose (0.9 mg/kg).</p><p><b>Conclusions:</b> When combined with G-CSF, BKT140 is a safe and efficient stem cell mobilizer that enabled the collection of a high number of CD34⁺ cells in 1 and 2 aphaeresis procedures, resulting in successful engraftment. <i>Clin Cancer Res; 20(2); 469–79. ©2013 AACR</i>.</p></div>" @default.
• W4361961370 created "2023-04-05" @default.
• W4361961370 creator A5009285339 @default.
• W4361961370 creator A5014494339 @default.
• W4361961370 creator A5020301140 @default.
• W4361961370 creator A5020369336 @default.
• W4361961370 creator A5027697717 @default.
• W4361961370 creator A5032207018 @default.
• W4361961370 creator A5038012218 @default.
• W4361961370 creator A5042191484 @default.
• W4361961370 creator A5049293551 @default.
• W4361961370 creator A5058925624 @default.
• W4361961370 creator A5062667726 @default.
• W4361961370 creator A5068847117 @default.
• W4361961370 creator A5072991940 @default.
• W4361961370 creator A5078502019 @default.
• W4361961370 creator A5079688295 @default.
• W4361961370 creator A5083036620 @default.
• W4361961370 creator A5090206769 @default.
• W4361961370 date "2023-03-31" @default.
• W4361961370 modified "2023-10-14" @default.
• W4361961370 title "Data from The High-Affinity CXCR4 Antagonist BKT140 Is Safe and Induces a Robust Mobilization of Human CD34⁺ Cells in Patients with Multiple Myeloma" @default.
• W4361961370 doi "https://doi.org/10.1158/1078-0432.c.6521523" @default.
• W4361961370 hasPublicationYear "2023" @default.
• W4361961370 type Work @default.
• W4361961370 citedByCount "0" @default.
• W4361961370 crossrefType "posted-content" @default.
• W4361961370 hasAuthorship W4361961370A5009285339 @default.
• W4361961370 hasAuthorship W4361961370A5014494339 @default.
• W4361961370 hasAuthorship W4361961370A5020301140 @default.
• W4361961370 hasAuthorship W4361961370A5020369336 @default.
• W4361961370 hasAuthorship W4361961370A5027697717 @default.
• W4361961370 hasAuthorship W4361961370A5032207018 @default.
• W4361961370 hasAuthorship W4361961370A5038012218 @default.
• W4361961370 hasAuthorship W4361961370A5042191484 @default.
• W4361961370 hasAuthorship W4361961370A5049293551 @default.
• W4361961370 hasAuthorship W4361961370A5058925624 @default.
• W4361961370 hasAuthorship W4361961370A5062667726 @default.
• W4361961370 hasAuthorship W4361961370A5068847117 @default.
• W4361961370 hasAuthorship W4361961370A5072991940 @default.
• W4361961370 hasAuthorship W4361961370A5078502019 @default.
• W4361961370 hasAuthorship W4361961370A5079688295 @default.
• W4361961370 hasAuthorship W4361961370A5083036620 @default.
• W4361961370 hasAuthorship W4361961370A5090206769 @default.
• W4361961370 hasConcept C126322002 @default.
• W4361961370 hasConcept C129470790 @default.
• W4361961370 hasConcept C13373296 @default.
• W4361961370 hasConcept C16685009 @default.
• W4361961370 hasConcept C170493617 @default.
• W4361961370 hasConcept C185592680 @default.
• W4361961370 hasConcept C2776364478 @default.
• W4361961370 hasConcept C2776694085 @default.
• W4361961370 hasConcept C2777767877 @default.
• W4361961370 hasConcept C2778828106 @default.
• W4361961370 hasConcept C2779050716 @default.
• W4361961370 hasConcept C28328180 @default.
• W4361961370 hasConcept C2911091166 @default.
• W4361961370 hasConcept C71924100 @default.
• W4361961370 hasConcept C86803240 @default.
• W4361961370 hasConcept C95444343 @default.
• W4361961370 hasConceptScore W4361961370C126322002 @default.
• W4361961370 hasConceptScore W4361961370C129470790 @default.
• W4361961370 hasConceptScore W4361961370C13373296 @default.
• W4361961370 hasConceptScore W4361961370C16685009 @default.
• W4361961370 hasConceptScore W4361961370C170493617 @default.
• W4361961370 hasConceptScore W4361961370C185592680 @default.
• W4361961370 hasConceptScore W4361961370C2776364478 @default.
• W4361961370 hasConceptScore W4361961370C2776694085 @default.
• W4361961370 hasConceptScore W4361961370C2777767877 @default.
• W4361961370 hasConceptScore W4361961370C2778828106 @default.
• W4361961370 hasConceptScore W4361961370C2779050716 @default.
• W4361961370 hasConceptScore W4361961370C28328180 @default.
• W4361961370 hasConceptScore W4361961370C2911091166 @default.
• W4361961370 hasConceptScore W4361961370C71924100 @default.
• W4361961370 hasConceptScore W4361961370C86803240 @default.
• W4361961370 hasConceptScore W4361961370C95444343 @default.
• W4361961370 hasLocation W43619613701 @default.
• W4361961370 hasOpenAccess W4361961370 @default.
• W4361961370 hasPrimaryLocation W43619613701 @default.
• W4361961370 hasRelatedWork W1895328588 @default.
• W4361961370 hasRelatedWork W2016206185 @default.
• W4361961370 hasRelatedWork W2087898292 @default.
• W4361961370 hasRelatedWork W2158737833 @default.
• W4361961370 hasRelatedWork W2589074632 @default.
• W4361961370 hasRelatedWork W2589873756 @default.
• W4361961370 hasRelatedWork W2750897134 @default.
• W4361961370 hasRelatedWork W4247486082 @default.
• W4361961370 hasRelatedWork W4283314663 @default.
• W4361961370 hasRelatedWork W4310119485 @default.
• W4361961370 isParatext "false" @default.
• W4361961370 isRetracted "false" @default.
• W4361961370 workType "article" @default.