FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361961608> ?p ?o ?g. }

• W4361961608 abstract "<div>Abstract<p><b>Purpose:</b> Drug resistance in brain tumors is partially mediated by the blood-brain barrier of which a key component is P-glycoprotein, which is highly expressed in cerebral capillaries. Tamoxifen is a nontoxic inhibitor of P-glycoprotein. This trial assessed, in primary and metastatic brain tumors, the differential deposition of paclitaxel and whether tamoxifen could increase paclitaxel deposition.</p><p><b>Experimental Design:</b> Patients for surgical resection of their primary or metastatic brain tumors were prospectively randomized to prior paclitaxel alone (175 mg/m²/i.v.) or tamoxifen for 5 days followed by paclitaxel. Central and peripheral tumor, surrounding normal brain and plasma, were analyzed for paclitaxel and tamoxifen.</p><p><b>Results:</b> Twenty-seven patients completed the study. Based on a multivariate linear regression model, no significant differences in paclitaxel concentrations between the two study arms were found after adjusting for treatment group (tamoxifen versus control). However, in analysis for tumor type, metastatic brain tumors had higher paclitaxel concentrations in the tumor center (1.93-fold, <i>P</i> = 0.10) and in the tumor periphery (2.46-fold, <i>P</i> = 0.039) compared with primary brain tumors. Pharmacokinetic analyses showed comparable paclitaxel areas under the serum concentration between treatment arms.</p><p><b>Conclusions</b>: Paclitaxel deposition was not increased with this tamoxifen schedule as the low plasma concentrations were likely secondary to concurrent use of P-450-inducing medications. However, the statistically higher paclitaxel deposition in the periphery of metastatic brain tumors provides functional evidence corroborating reports of decreased P-glycoprotein expression in metastatic versus primary brain tumors. This suggests that metastatic brain tumors may respond to paclitaxel if it has proven clinical efficacy for the primary tumor's histopathology.</p></div>" @default.
• W4361961608 created "2023-04-05" @default.
• W4361961608 creator A5002273026 @default.
• W4361961608 creator A5008597138 @default.
• W4361961608 creator A5010408277 @default.
• W4361961608 creator A5011967890 @default.
• W4361961608 creator A5026198934 @default.
• W4361961608 creator A5032969374 @default.
• W4361961608 creator A5055848888 @default.
• W4361961608 creator A5057660160 @default.
• W4361961608 creator A5060292633 @default.
• W4361961608 creator A5074628106 @default.
• W4361961608 creator A5075752889 @default.
• W4361961608 creator A5077159444 @default.
• W4361961608 date "2023-03-31" @default.
• W4361961608 modified "2023-10-14" @default.
• W4361961608 title "Data from Randomized Study of Paclitaxel and Tamoxifen Deposition into Human Brain Tumors: Implications for the Treatment of Metastatic Brain Tumors" @default.
• W4361961608 doi "https://doi.org/10.1158/1078-0432.c.6518784" @default.
• W4361961608 hasPublicationYear "2023" @default.
• W4361961608 type Work @default.
• W4361961608 citedByCount "0" @default.
• W4361961608 crossrefType "posted-content" @default.
• W4361961608 hasAuthorship W4361961608A5002273026 @default.
• W4361961608 hasAuthorship W4361961608A5008597138 @default.
• W4361961608 hasAuthorship W4361961608A5010408277 @default.
• W4361961608 hasAuthorship W4361961608A5011967890 @default.
• W4361961608 hasAuthorship W4361961608A5026198934 @default.
• W4361961608 hasAuthorship W4361961608A5032969374 @default.
• W4361961608 hasAuthorship W4361961608A5055848888 @default.
• W4361961608 hasAuthorship W4361961608A5057660160 @default.
• W4361961608 hasAuthorship W4361961608A5060292633 @default.
• W4361961608 hasAuthorship W4361961608A5074628106 @default.
• W4361961608 hasAuthorship W4361961608A5075752889 @default.
• W4361961608 hasAuthorship W4361961608A5077159444 @default.
• W4361961608 hasBestOaLocation W43619616082 @default.
• W4361961608 hasConcept C121608353 @default.
• W4361961608 hasConcept C126322002 @default.
• W4361961608 hasConcept C134018914 @default.
• W4361961608 hasConcept C142724271 @default.
• W4361961608 hasConcept C143998085 @default.
• W4361961608 hasConcept C2776694085 @default.
• W4361961608 hasConcept C2777176818 @default.
• W4361961608 hasConcept C2777292972 @default.
• W4361961608 hasConcept C2779130545 @default.
• W4361961608 hasConcept C530470458 @default.
• W4361961608 hasConcept C71924100 @default.
• W4361961608 hasConceptScore W4361961608C121608353 @default.
• W4361961608 hasConceptScore W4361961608C126322002 @default.
• W4361961608 hasConceptScore W4361961608C134018914 @default.
• W4361961608 hasConceptScore W4361961608C142724271 @default.
• W4361961608 hasConceptScore W4361961608C143998085 @default.
• W4361961608 hasConceptScore W4361961608C2776694085 @default.
• W4361961608 hasConceptScore W4361961608C2777176818 @default.
• W4361961608 hasConceptScore W4361961608C2777292972 @default.
• W4361961608 hasConceptScore W4361961608C2779130545 @default.
• W4361961608 hasConceptScore W4361961608C530470458 @default.
• W4361961608 hasConceptScore W4361961608C71924100 @default.
• W4361961608 hasLocation W43619616081 @default.
• W4361961608 hasLocation W43619616082 @default.
• W4361961608 hasOpenAccess W4361961608 @default.
• W4361961608 hasPrimaryLocation W43619616081 @default.
• W4361961608 hasRelatedWork W1771722205 @default.
• W4361961608 hasRelatedWork W1987496817 @default.
• W4361961608 hasRelatedWork W2009869235 @default.
• W4361961608 hasRelatedWork W2015092588 @default.
• W4361961608 hasRelatedWork W2026707439 @default.
• W4361961608 hasRelatedWork W2091599823 @default.
• W4361961608 hasRelatedWork W2172254302 @default.
• W4361961608 hasRelatedWork W2460391067 @default.
• W4361961608 hasRelatedWork W2464051959 @default.
• W4361961608 hasRelatedWork W2926335606 @default.
• W4361961608 isParatext "false" @default.
• W4361961608 isRetracted "false" @default.
• W4361961608 workType "article" @default.