Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361964776> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4361964776 abstract "<div>AbstractPurpose:<p>The stromal and immune bone marrow (BM) landscape is emerging as a crucial determinant for acute myeloid leukemia (AML). Regulatory T cells (Treg) are enriched in the AML microenvironment, but the underlying mechanisms are poorly elucidated. Here, we addressed the effect of IFNγ released by AML cells in BM Treg induction and its impact on AML prognosis.</p>Experimental Design:<p>BM aspirates from patients with AML were subdivided according to <i>IFNG</i> expression. Gene expression profiles in INFγ<sup>high</sup> and IFNγ<sup>low</sup> samples were compared by microarray and NanoString analysis and used to compute a prognostic index. The IFNγ release effect on the BM microenvironment was investigated in mesenchymal stromal cell (MSC)/AML cell cocultures. In mice, AML cells silenced for <i>ifng</i> expression were injected intrabone.</p>Results:<p>IFNγ<sup>high</sup> AML samples showed an upregulation of inflammatory genes, usually correlated with a good prognosis in cancer. In contrast, in patients with AML, high <i>IFNG</i> expression was associated with poor overall survival. Notably, IFNγ release by AML cells positively correlated with a higher BM suppressive Treg frequency. In coculture experiments, IFNγ<sup>high</sup> AML cells modified MSC transcriptome by upregulating IFNγ-dependent genes related to Treg induction, including indoleamine 2,3-dioxygenase 1 (<i>IDO1</i>). IDO1 inhibitor abrogated the effect of IFNγ release by AML cells on MSC-derived Treg induction. <i>In vivo</i>, the genetic ablation of IFNγ production by AML cells reduced MSC IDO1 expression and Treg infiltration, hindering AML engraftment.</p>Conclusions:<p>IFNγ release by AML cells induces an immune-regulatory program in MSCs and remodels BM immunologic landscape toward Treg induction, contributing to an immunotolerant microenvironment.</p><p><i><a href=https://aacrjournals.org/clincancerres/article/doi/10.1158/1078-0432.CCR-22-1030 target=_blank>See related commentary by Ferrell and Kordasti, p. 2986</a></i></p></div>" @default.
- W4361964776 created "2023-04-05" @default.
- W4361964776 creator A5002381343 @default.
- W4361964776 creator A5009148538 @default.
- W4361964776 creator A5018826562 @default.
- W4361964776 creator A5021127758 @default.
- W4361964776 creator A5023529754 @default.
- W4361964776 creator A5028518722 @default.
- W4361964776 creator A5029407987 @default.
- W4361964776 creator A5036575248 @default.
- W4361964776 creator A5037140934 @default.
- W4361964776 creator A5042573600 @default.
- W4361964776 creator A5044355450 @default.
- W4361964776 creator A5045670968 @default.
- W4361964776 creator A5054016975 @default.
- W4361964776 creator A5071142474 @default.
- W4361964776 creator A5071926851 @default.
- W4361964776 creator A5072253025 @default.
- W4361964776 creator A5073761054 @default.
- W4361964776 creator A5074486528 @default.
- W4361964776 creator A5081264460 @default.
- W4361964776 creator A5088581133 @default.
- W4361964776 date "2023-03-31" @default.
- W4361964776 modified "2023-09-24" @default.
- W4361964776 title "Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells" @default.
- W4361964776 doi "https://doi.org/10.1158/1078-0432.c.6532505" @default.
- W4361964776 hasPublicationYear "2023" @default.
- W4361964776 type Work @default.
- W4361964776 citedByCount "0" @default.
- W4361964776 crossrefType "posted-content" @default.
- W4361964776 hasAuthorship W4361964776A5002381343 @default.
- W4361964776 hasAuthorship W4361964776A5009148538 @default.
- W4361964776 hasAuthorship W4361964776A5018826562 @default.
- W4361964776 hasAuthorship W4361964776A5021127758 @default.
- W4361964776 hasAuthorship W4361964776A5023529754 @default.
- W4361964776 hasAuthorship W4361964776A5028518722 @default.
- W4361964776 hasAuthorship W4361964776A5029407987 @default.
- W4361964776 hasAuthorship W4361964776A5036575248 @default.
- W4361964776 hasAuthorship W4361964776A5037140934 @default.
- W4361964776 hasAuthorship W4361964776A5042573600 @default.
- W4361964776 hasAuthorship W4361964776A5044355450 @default.
- W4361964776 hasAuthorship W4361964776A5045670968 @default.
- W4361964776 hasAuthorship W4361964776A5054016975 @default.
- W4361964776 hasAuthorship W4361964776A5071142474 @default.
- W4361964776 hasAuthorship W4361964776A5071926851 @default.
- W4361964776 hasAuthorship W4361964776A5072253025 @default.
- W4361964776 hasAuthorship W4361964776A5073761054 @default.
- W4361964776 hasAuthorship W4361964776A5074486528 @default.
- W4361964776 hasAuthorship W4361964776A5081264460 @default.
- W4361964776 hasAuthorship W4361964776A5088581133 @default.
- W4361964776 hasConcept C104317684 @default.
- W4361964776 hasConcept C127561419 @default.
- W4361964776 hasConcept C153911025 @default.
- W4361964776 hasConcept C16930146 @default.
- W4361964776 hasConcept C203014093 @default.
- W4361964776 hasConcept C2776107976 @default.
- W4361964776 hasConcept C2778461978 @default.
- W4361964776 hasConcept C2778729363 @default.
- W4361964776 hasConcept C2779282312 @default.
- W4361964776 hasConcept C2780007613 @default.
- W4361964776 hasConcept C502942594 @default.
- W4361964776 hasConcept C55493867 @default.
- W4361964776 hasConcept C71924100 @default.
- W4361964776 hasConcept C86803240 @default.
- W4361964776 hasConcept C8891405 @default.
- W4361964776 hasConceptScore W4361964776C104317684 @default.
- W4361964776 hasConceptScore W4361964776C127561419 @default.
- W4361964776 hasConceptScore W4361964776C153911025 @default.
- W4361964776 hasConceptScore W4361964776C16930146 @default.
- W4361964776 hasConceptScore W4361964776C203014093 @default.
- W4361964776 hasConceptScore W4361964776C2776107976 @default.
- W4361964776 hasConceptScore W4361964776C2778461978 @default.
- W4361964776 hasConceptScore W4361964776C2778729363 @default.
- W4361964776 hasConceptScore W4361964776C2779282312 @default.
- W4361964776 hasConceptScore W4361964776C2780007613 @default.
- W4361964776 hasConceptScore W4361964776C502942594 @default.
- W4361964776 hasConceptScore W4361964776C55493867 @default.
- W4361964776 hasConceptScore W4361964776C71924100 @default.
- W4361964776 hasConceptScore W4361964776C86803240 @default.
- W4361964776 hasConceptScore W4361964776C8891405 @default.
- W4361964776 hasLocation W43619647761 @default.
- W4361964776 hasOpenAccess W4361964776 @default.
- W4361964776 hasPrimaryLocation W43619647761 @default.
- W4361964776 hasRelatedWork W1975473919 @default.
- W4361964776 hasRelatedWork W2121159001 @default.
- W4361964776 hasRelatedWork W2360105106 @default.
- W4361964776 hasRelatedWork W2363513141 @default.
- W4361964776 hasRelatedWork W2729031813 @default.
- W4361964776 hasRelatedWork W2977159846 @default.
- W4361964776 hasRelatedWork W3010976621 @default.
- W4361964776 hasRelatedWork W3015340136 @default.
- W4361964776 hasRelatedWork W42711520 @default.
- W4361964776 hasRelatedWork W4320019111 @default.
- W4361964776 isParatext "false" @default.
- W4361964776 isRetracted "false" @default.
- W4361964776 workType "article" @default.