FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362237182> ?p ?o ?g. }

• W4362237182 abstract "<sec> <title>BACKGROUND</title> Asthma attacks are a common and important problem. Someone experiences an asthma attack in the United Kingdom every 10 seconds. Asthma attacks cause coughing, wheezing, breathlessness, and chest tightness and are highly stressful for patients. They result in reduced quality of life, with days lost from work or school. Asthma attacks are treated with oral corticosteroids (OCSs), but these have many short- and long-term side effects. Asthma monoclonal antibodies (mAbs) have revolutionized the treatment of severe asthma by reducing asthma attacks and OCS burden by over 50%, but some people still experience attacks while on mAbs. The MEX study showed that residual asthma attacks are broadly eosinophilic (high fractional exhaled nitric oxide [FeNO]) or noneosinophilic (low FeNO), but it did not measure response to OCS treatment. There is an evidence gap in understanding the clinical and inflammatory responses that occur when using OCSs to treat residual asthma attacks in patients taking asthma mAbs. </sec> <sec> <title>OBJECTIVE</title> The primary objective is to compare the clinical recovery between high-FeNO and low-FeNO attacks after acute treatment with oral prednisolone among people established on long-term asthma mAb treatment. The exploratory objective is to compare the inflammatory response to acute treatment with oral prednisolone between high-FeNO and low-FeNO attacks. </sec> <sec> <title>METHODS</title> BOOST (Breakthrough Asthma Attacks Treated With Oral Steroids) is a single-center, prospective observational study of 60 adults established on long-term asthma mAb treatment who receive acute treatment with oral prednisolone (usual care) for an asthma attack. The primary outcome will be the proportion of treatment failure (the need to start oral prednisolone or antibiotics or an unscheduled health care visit for asthma, following an attack) at day 28. The secondary outcomes will be the change in forced expiratory volume in 1 second and the change in visual analogue scale symptom score between the stable state, attack, day 7, and day 28 visits. The exploratory outcomes include the changes in sputum, nasal, and blood inflammometry between the stable state, attack, day 7, and day 28 visits. </sec> <sec> <title>RESULTS</title> The last asthma attack visit is anticipated to occur in December 2023. Data analysis and publication will take place in 2024. </sec> <sec> <title>CONCLUSIONS</title> We will test the hypothesis that there is a difference in the rate of recovery of clinical and inflammatory measures between high-FeNO and low-FeNO asthma attacks that occur in patients on mAb therapy. The study data will help power a future randomized placebo-controlled trial of prednisolone treatment for nonsevere attacks in patients treated with asthma mAbs and will provide important information on whether corticosteroid treatment should be FeNO-directed. </sec> <sec> <title>INTERNATIONAL REGISTERED REPORT</title> DERR1-10.2196/46741 </sec>" @default.
• W4362237182 created "2023-04-05" @default.
• W4362237182 creator A5021121714 @default.
• W4362237182 creator A5022945711 @default.
• W4362237182 creator A5034784907 @default.
• W4362237182 creator A5036198009 @default.
• W4362237182 creator A5039795448 @default.
• W4362237182 creator A5046586779 @default.
• W4362237182 creator A5058118679 @default.
• W4362237182 creator A5078489750 @default.
• W4362237182 date "2023-03-28" @default.
• W4362237182 modified "2023-10-16" @default.
• W4362237182 title "Recovery of Breakthrough Asthma Attacks Treated With Oral Steroids While on Monoclonal Antibody Therapy: Protocol for a Prospective Observational Study (BOOST) (Preprint)" @default.
• W4362237182 doi "https://doi.org/10.2196/preprints.46741" @default.
• W4362237182 hasPublicationYear "2023" @default.
• W4362237182 type Work @default.
• W4362237182 citedByCount "0" @default.
• W4362237182 crossrefType "posted-content" @default.
• W4362237182 hasAuthorship W4362237182A5021121714 @default.
• W4362237182 hasAuthorship W4362237182A5022945711 @default.
• W4362237182 hasAuthorship W4362237182A5034784907 @default.
• W4362237182 hasAuthorship W4362237182A5036198009 @default.
• W4362237182 hasAuthorship W4362237182A5039795448 @default.
• W4362237182 hasAuthorship W4362237182A5046586779 @default.
• W4362237182 hasAuthorship W4362237182A5058118679 @default.
• W4362237182 hasAuthorship W4362237182A5078489750 @default.
• W4362237182 hasBestOaLocation W43622371822 @default.
• W4362237182 hasConcept C126322002 @default.
• W4362237182 hasConcept C187212893 @default.
• W4362237182 hasConcept C23131810 @default.
• W4362237182 hasConcept C2776042228 @default.
• W4362237182 hasConcept C2776715498 @default.
• W4362237182 hasConcept C2780769369 @default.
• W4362237182 hasConcept C2781142857 @default.
• W4362237182 hasConcept C71924100 @default.
• W4362237182 hasConceptScore W4362237182C126322002 @default.
• W4362237182 hasConceptScore W4362237182C187212893 @default.
• W4362237182 hasConceptScore W4362237182C23131810 @default.
• W4362237182 hasConceptScore W4362237182C2776042228 @default.
• W4362237182 hasConceptScore W4362237182C2776715498 @default.
• W4362237182 hasConceptScore W4362237182C2780769369 @default.
• W4362237182 hasConceptScore W4362237182C2781142857 @default.
• W4362237182 hasConceptScore W4362237182C71924100 @default.
• W4362237182 hasLocation W43622371821 @default.
• W4362237182 hasLocation W43622371822 @default.
• W4362237182 hasOpenAccess W4362237182 @default.
• W4362237182 hasPrimaryLocation W43622371821 @default.
• W4362237182 hasRelatedWork W1849339974 @default.
• W4362237182 hasRelatedWork W2021999298 @default.
• W4362237182 hasRelatedWork W2038726642 @default.
• W4362237182 hasRelatedWork W2075765944 @default.
• W4362237182 hasRelatedWork W2182274185 @default.
• W4362237182 hasRelatedWork W2351199288 @default.
• W4362237182 hasRelatedWork W2391351959 @default.
• W4362237182 hasRelatedWork W3123540785 @default.
• W4362237182 hasRelatedWork W4322724676 @default.
• W4362237182 hasRelatedWork W65575745 @default.
• W4362237182 isParatext "false" @default.
• W4362237182 isRetracted "false" @default.
• W4362237182 workType "article" @default.