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- W4362422182 abstract "<p>This file contains 9 supplemental figures and 3 supplemental tables. Supplemental Figure 1. There are four potential binding sites (red) for NF-Y in the 1kb upstream region of the ZDHHC5 promoter. Supplemental Figure 2. The mutant p53 and NF-Y co-recruit onto the ZDHHC5 promoter. Supplemental Figure 3. Genetic, differentiated and proliferative characteristics of CA-KRAS/hTERT/DN-p53/ZDHHC5 hNSCs. Supplemental Figure 4. There is co-expression of ZDHHC5 and SOX2 or CD133 in p53 mutant glioma samples and glioma stem cells. Supplemental Figure 5. ZDHHC5 regulates self-renewal of p53 mutant GSCs. Supplemental Figure 6. ZDHHC5 regulates tumor angiogenesis in xenografted brain tumors from p53 mutant GSCs. Supplemental Figure 7. ZDHHC5 specifically regulates EZH2 palmitoyaltion level and EZH2-mediated colony formation and cell migartion. Supplemental Figure 8. The EZH2 potential palmitoyaltion sites which are conserved in different species. Supplemental Figure 9. ZDHHC5 regulates EZH2-mediated glioma development. Supplemental Table1. p53 mutational status in glioma. Supplemental Table2. The Relationship between ZDHHC5 expression and p53 mutantional status in glioma. Supplemental Table 3. Limiting dilution tumor formation of p53 mutant GSCs transfected with or without ZDHHC5 shRNA.</p>" @default.
- W4362422182 created "2023-04-05" @default.
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- W4362422182 date "2023-03-31" @default.
- W4362422182 modified "2023-09-25" @default.
- W4362422182 title "Supplemental Figures and Tables from EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression" @default.
- W4362422182 doi "https://doi.org/10.1158/0008-5472.22416654.v1" @default.
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