FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362449407> ?p ?o ?g. }

• W4362449407 endingPage "573" @default.
• W4362449407 startingPage "563" @default.
• W4362449407 abstract "This work aimed to assess whether mitochondrial damage in the liver induced by subacute soman exposure is caused by peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) and whether PGC-1α regulates mitochondrial respiratory chain damage. Toxicity mechanism research may provide theoretical support for developing anti-toxic drugs in the future. First, a soman animal model was established in male Sprague-Dawley (SD) rats by subcutaneous soman injection. Then, liver damage was biochemically evaluated, and acetylcholinesterase (AChE) activity was also determined. Transmission electron microscopy (TEM) was performed to examine liver mitochondrial damage, and high-resolution respirometry was carried out for assessing mitochondrial respiration function. In addition, complex I-IV levels were quantitatively evaluated in isolated liver mitochondria by enzyme-linked immunosorbent assay (ELISA). PGC-1α levels were detected with a Jess capillary-based immunoassay device. Finally, oxidative stress was analyzed by quantifying superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), oxidized glutathione (GSSG), and reactive oxygen species (ROS) levels. Repeated low-level soman exposure did not alter AChE activity, while increasing morphological damage of liver mitochondria and liver enzyme levels in rat homogenates. Complex I, II and I + II activities were 2.33, 4.95, and 5.22 times lower after treatment compared with the control group, respectively. Among complexes I-IV, I-III decreased significantly (p < 0.05), and PGC-1α levels were 1.82 times lower after soman exposure than in the control group. Subacute soman exposure significantly increased mitochondrial ROS production, which may cause oxidate stress. These findings indicated dysregulated mitochondrial energy metabolism involves PGC-1α protein expression imbalance, revealing non-cholinergic mechanisms for soman toxicity." @default.
• W4362449407 created "2023-04-05" @default.
• W4362449407 creator A5006746441 @default.
• W4362449407 creator A5011862588 @default.
• W4362449407 creator A5013038112 @default.
• W4362449407 creator A5016901846 @default.
• W4362449407 creator A5043608454 @default.
• W4362449407 creator A5044544424 @default.
• W4362449407 creator A5049657537 @default.
• W4362449407 creator A5050878785 @default.
• W4362449407 creator A5052070034 @default.
• W4362449407 creator A5055265608 @default.
• W4362449407 creator A5074056694 @default.
• W4362449407 creator A5080144719 @default.
• W4362449407 date "2023-04-01" @default.
• W4362449407 modified "2023-10-06" @default.
• W4362449407 title "PGC 1α-Mediates Mitochondrial Damage in the Liver by Inhibiting the Mitochondrial Respiratory Chain as a Non-cholinergic Mechanism of Repeated Low-Level Soman Exposure" @default.
• W4362449407 cites W1503760388 @default.
• W4362449407 cites W1802686741 @default.
• W4362449407 cites W1803267321 @default.
• W4362449407 cites W18062046 @default.
• W4362449407 cites W1971048984 @default.
• W4362449407 cites W1971063609 @default.
• W4362449407 cites W1971424254 @default.
• W4362449407 cites W1972729852 @default.
• W4362449407 cites W1975045295 @default.
• W4362449407 cites W1978756251 @default.
• W4362449407 cites W1987144250 @default.
• W4362449407 cites W1997121318 @default.
• W4362449407 cites W1998938457 @default.
• W4362449407 cites W2000582099 @default.
• W4362449407 cites W2003565525 @default.
• W4362449407 cites W2029857264 @default.
• W4362449407 cites W2030031992 @default.
• W4362449407 cites W2033347681 @default.
• W4362449407 cites W2038537185 @default.
• W4362449407 cites W2041409896 @default.
• W4362449407 cites W2043910792 @default.
• W4362449407 cites W2053807799 @default.
• W4362449407 cites W2060110413 @default.
• W4362449407 cites W2076541549 @default.
• W4362449407 cites W2080065651 @default.
• W4362449407 cites W2080520432 @default.
• W4362449407 cites W2080714150 @default.
• W4362449407 cites W2081472732 @default.
• W4362449407 cites W2081703555 @default.
• W4362449407 cites W2086276885 @default.
• W4362449407 cites W2086411642 @default.
• W4362449407 cites W2092888258 @default.
• W4362449407 cites W2098436069 @default.
• W4362449407 cites W2124612536 @default.
• W4362449407 cites W2124920972 @default.
• W4362449407 cites W2127659234 @default.
• W4362449407 cites W2141789735 @default.
• W4362449407 cites W2155337367 @default.
• W4362449407 cites W2162818878 @default.
• W4362449407 cites W2172198013 @default.
• W4362449407 cites W2172873243 @default.
• W4362449407 cites W2321700180 @default.
• W4362449407 cites W2471580427 @default.
• W4362449407 cites W2594188719 @default.
• W4362449407 cites W2605384809 @default.
• W4362449407 cites W2610198299 @default.
• W4362449407 cites W2776510140 @default.
• W4362449407 cites W2790006482 @default.
• W4362449407 cites W2791234163 @default.
• W4362449407 cites W2795211866 @default.
• W4362449407 cites W3045052002 @default.
• W4362449407 cites W3047740470 @default.
• W4362449407 cites W3123756879 @default.
• W4362449407 cites W3128347947 @default.
• W4362449407 cites W3130548458 @default.
• W4362449407 cites W3163985848 @default.
• W4362449407 cites W3179416847 @default.
• W4362449407 cites W4211173363 @default.
• W4362449407 cites W59350189 @default.
• W4362449407 doi "https://doi.org/10.1248/bpb.b22-00633" @default.
• W4362449407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37005300" @default.
• W4362449407 hasPublicationYear "2023" @default.
• W4362449407 type Work @default.
• W4362449407 citedByCount "0" @default.
• W4362449407 crossrefType "journal-article" @default.
• W4362449407 hasAuthorship W4362449407A5006746441 @default.
• W4362449407 hasAuthorship W4362449407A5011862588 @default.
• W4362449407 hasAuthorship W4362449407A5013038112 @default.
• W4362449407 hasAuthorship W4362449407A5016901846 @default.
• W4362449407 hasAuthorship W4362449407A5043608454 @default.
• W4362449407 hasAuthorship W4362449407A5044544424 @default.
• W4362449407 hasAuthorship W4362449407A5049657537 @default.
• W4362449407 hasAuthorship W4362449407A5050878785 @default.
• W4362449407 hasAuthorship W4362449407A5052070034 @default.
• W4362449407 hasAuthorship W4362449407A5055265608 @default.
• W4362449407 hasAuthorship W4362449407A5074056694 @default.
• W4362449407 hasAuthorship W4362449407A5080144719 @default.
• W4362449407 hasBestOaLocation W43624494071 @default.
• W4362449407 hasConcept C126322002 @default.
• W4362449407 hasConcept C134018914 @default.
• W4362449407 hasConcept C181199279 @default.

• next