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- W4362458413 abstract "The first total synthesis of the natural product (13R,14S,15R)-13-hydroxy-14-deoxyoxacyclododecindione, which was isolated in 2018 as a member of the oxacyclododecindione family, is reported. A synthetic strategy through intramolecular Friedel-Crafts acylation combined with the stereoselective synthesis of a new triol key fragment allowed the preparation of the macrolactone. Due to mismatching physical data of the synthetic product, a revision of the configuration of the natural product isolated in 2018 is required. Light-induced E/Z-isomerism of the macrolactone backbone is described for the first time in the class of oxacyclododecindione-type macrolactones. The hydroxylated macrolactone prepared herein was found to show highly promising IC50 values in biological assays addressing the inhibition of inflammatory responses." @default.
- W4362458413 created "2023-04-05" @default.
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- W4362458413 date "2023-03-31" @default.
- W4362458413 modified "2023-10-04" @default.
- W4362458413 title "Total Synthesis and Biological Evaluation of the Anti-Inflammatory (13<i>R</i>,14<i>S</i>,15<i>R</i>)-13-Hydroxy-14-deoxyoxacyclododecindione" @default.
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- W4362458413 doi "https://doi.org/10.1021/acs.jnatprod.2c01145" @default.
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