Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362458578> ?p ?o ?g. }
- W4362458578 endingPage "94" @default.
- W4362458578 startingPage "71" @default.
- W4362458578 abstract "Summary The mevalonate pathway is an essential metabolic pathway in T cells regulating development, proliferation, survival, differentiation, and effector functions. The mevalonate pathway is a complex, branched pathway composed of many enzymes that ultimately generate cholesterol and nonsterol isoprenoids. T cells must tightly control metabolic flux through the branches of the mevalonate pathway to ensure sufficient isoprenoids and cholesterol are available to meet cellular demands. Unbalanced metabolite flux through the sterol or the nonsterol isoprenoid branch is metabolically inefficient and can have deleterious consequences for T cell fate and function. Accordingly, there is tight regulatory control over metabolic flux through the branches of this essential lipid synthetic pathway. In this review we provide an overview of how the branches of the mevalonate pathway are regulated in T cells and discuss our current understanding of the relationship between mevalonate metabolism, cholesterol homeostasis and T cell function." @default.
- W4362458578 created "2023-04-05" @default.
- W4362458578 creator A5032593786 @default.
- W4362458578 creator A5064530526 @default.
- W4362458578 date "2023-03-31" @default.
- W4362458578 modified "2023-10-10" @default.
- W4362458578 title "Decoding the crosstalk between mevalonate metabolism and T cell function" @default.
- W4362458578 cites W1482928030 @default.
- W4362458578 cites W1483342710 @default.
- W4362458578 cites W1513050884 @default.
- W4362458578 cites W1545863889 @default.
- W4362458578 cites W1550903142 @default.
- W4362458578 cites W1556918753 @default.
- W4362458578 cites W1557392502 @default.
- W4362458578 cites W1558765348 @default.
- W4362458578 cites W1593627702 @default.
- W4362458578 cites W1602179460 @default.
- W4362458578 cites W1603091820 @default.
- W4362458578 cites W1604544257 @default.
- W4362458578 cites W1606948338 @default.
- W4362458578 cites W1852629292 @default.
- W4362458578 cites W1860242155 @default.
- W4362458578 cites W1875102167 @default.
- W4362458578 cites W1907316344 @default.
- W4362458578 cites W1944331591 @default.
- W4362458578 cites W1958617503 @default.
- W4362458578 cites W1967727543 @default.
- W4362458578 cites W1968064063 @default.
- W4362458578 cites W1969632377 @default.
- W4362458578 cites W1970058349 @default.
- W4362458578 cites W1970400427 @default.
- W4362458578 cites W1970612654 @default.
- W4362458578 cites W1974424684 @default.
- W4362458578 cites W1977595948 @default.
- W4362458578 cites W1977644047 @default.
- W4362458578 cites W1980857453 @default.
- W4362458578 cites W1982926925 @default.
- W4362458578 cites W1983558530 @default.
- W4362458578 cites W1985462906 @default.
- W4362458578 cites W1986013003 @default.
- W4362458578 cites W1986053870 @default.
- W4362458578 cites W1989488426 @default.
- W4362458578 cites W1993439431 @default.
- W4362458578 cites W1996168740 @default.
- W4362458578 cites W1998203489 @default.
- W4362458578 cites W1999094102 @default.
- W4362458578 cites W2001358928 @default.
- W4362458578 cites W2001387572 @default.
- W4362458578 cites W2006028058 @default.
- W4362458578 cites W2006205937 @default.
- W4362458578 cites W2006415446 @default.
- W4362458578 cites W2007873510 @default.
- W4362458578 cites W2008636329 @default.
- W4362458578 cites W2009616432 @default.
- W4362458578 cites W2009675211 @default.
- W4362458578 cites W2013937462 @default.
- W4362458578 cites W2016441481 @default.
- W4362458578 cites W2020988004 @default.
- W4362458578 cites W2024141615 @default.
- W4362458578 cites W2025714915 @default.
- W4362458578 cites W2026525843 @default.
- W4362458578 cites W2027699993 @default.
- W4362458578 cites W2033206973 @default.
- W4362458578 cites W2037590835 @default.
- W4362458578 cites W2039656447 @default.
- W4362458578 cites W2040641918 @default.
- W4362458578 cites W2041037030 @default.
- W4362458578 cites W2042584344 @default.
- W4362458578 cites W2044236689 @default.
- W4362458578 cites W2046367438 @default.
- W4362458578 cites W2050412627 @default.
- W4362458578 cites W2053100392 @default.
- W4362458578 cites W2054044953 @default.
- W4362458578 cites W2054728240 @default.
- W4362458578 cites W2055825597 @default.
- W4362458578 cites W2058743922 @default.
- W4362458578 cites W2063865193 @default.
- W4362458578 cites W2064656497 @default.
- W4362458578 cites W2065224940 @default.
- W4362458578 cites W2065681262 @default.
- W4362458578 cites W2066704041 @default.
- W4362458578 cites W2068987864 @default.
- W4362458578 cites W2070576765 @default.
- W4362458578 cites W2071123991 @default.
- W4362458578 cites W2071124826 @default.
- W4362458578 cites W2072033965 @default.
- W4362458578 cites W2072122733 @default.
- W4362458578 cites W2072517432 @default.
- W4362458578 cites W2073025161 @default.
- W4362458578 cites W2074996264 @default.
- W4362458578 cites W2077080652 @default.
- W4362458578 cites W2077971415 @default.
- W4362458578 cites W2078970200 @default.
- W4362458578 cites W2082275436 @default.
- W4362458578 cites W2082621592 @default.
- W4362458578 cites W2084561923 @default.
- W4362458578 cites W2085239881 @default.
- W4362458578 cites W2086432724 @default.