FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362459977> ?p ?o ?g. }

• W4362459977 endingPage "309" @default.
• W4362459977 startingPage "303" @default.
• W4362459977 abstract "TLR2 is one of 10 human TLRs, which plays an important role in the recognition of pathogens and activation of the innate immunity via NF‐κB pathway. NF‐κB activation induces the expression of various pro‐inflammatory genes. This study examines the effect of TLR2 polymorphisms on the production of blood pro‐inflammatory cytokines in healthy Finnish children. One hundred forty‐six children who participated in a prospective observational birth cohort study in Turku, Finland, were included. DNA samples were analysed by PCR‐based sequencing for two common TLR2 polymorphisms (rs5743708 Arg753Gln; rs111200466–196 to –174del). Serum concentrations of IL‐33, IL‐31, IL‐17A and IL‐17F were measured by multiplex immunoassay and sST2 by ELISA in children at the age of 13 months. Children with variant type of TLR2 rs111200466 (ins/del or del/del) had significantly lower level of serum IL‐33 (median, 0.00 pg/mL; IQR 0.00–17.60) than those with ins/ins type of TLR2 (19.81 pg/mL; IQR 0.00–51.78) (p = 0.0001). Almost all study subjects had serum concentrations of IL‐17A, IL‐17F and IL‐31 below the detection limit and therefore not included in the final analyses. No differences in levels of above four cytokines and sST2 were found between TLR2 rs5743708 genotypes (GG and GA). Our results indicated that the TLR2 rs111200466 deletion was associated with a low level of serum IL‐33, suggesting that the polymorphism may impair the production of IL‐33." @default.
• W4362459977 created "2023-04-05" @default.
• W4362459977 creator A5013185546 @default.
• W4362459977 creator A5039203052 @default.
• W4362459977 creator A5042296530 @default.
• W4362459977 creator A5042622188 @default.
• W4362459977 creator A5070691873 @default.
• W4362459977 date "2023-04-13" @default.
• W4362459977 modified "2023-09-30" @default.
• W4362459977 title "Association of <i>Toll‐like receptor 2</i> rs111200466 polymorphism with low serum levels of <scp>IL</scp>‐33 in early childhood" @default.
• W4362459977 cites W1888914942 @default.
• W4362459977 cites W1975915404 @default.
• W4362459977 cites W2006401826 @default.
• W4362459977 cites W2008797060 @default.
• W4362459977 cites W2009306027 @default.
• W4362459977 cites W2051252301 @default.
• W4362459977 cites W2085048516 @default.
• W4362459977 cites W2115101833 @default.
• W4362459977 cites W2127988591 @default.
• W4362459977 cites W2135644001 @default.
• W4362459977 cites W2175507590 @default.
• W4362459977 cites W2560069816 @default.
• W4362459977 cites W2567346915 @default.
• W4362459977 cites W2591366689 @default.
• W4362459977 cites W2594773093 @default.
• W4362459977 cites W2609744794 @default.
• W4362459977 cites W2610555703 @default.
• W4362459977 cites W2753613458 @default.
• W4362459977 cites W2779261498 @default.
• W4362459977 cites W2883390958 @default.
• W4362459977 cites W2891843538 @default.
• W4362459977 cites W2944795429 @default.
• W4362459977 cites W2991275545 @default.
• W4362459977 cites W2993466459 @default.
• W4362459977 cites W2995764816 @default.
• W4362459977 cites W3006588219 @default.
• W4362459977 cites W3024896255 @default.
• W4362459977 cites W3041635331 @default.
• W4362459977 cites W3142263587 @default.
• W4362459977 cites W3158340716 @default.
• W4362459977 cites W3188027618 @default.
• W4362459977 cites W3205669838 @default.
• W4362459977 cites W4280595083 @default.
• W4362459977 cites W4290805533 @default.
• W4362459977 doi "https://doi.org/10.1111/apm.13314" @default.
• W4362459977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37002184" @default.
• W4362459977 hasPublicationYear "2023" @default.
• W4362459977 type Work @default.
• W4362459977 citedByCount "1" @default.
• W4362459977 countsByYear W43624599772023 @default.
• W4362459977 crossrefType "journal-article" @default.
• W4362459977 hasAuthorship W4362459977A5013185546 @default.
• W4362459977 hasAuthorship W4362459977A5039203052 @default.
• W4362459977 hasAuthorship W4362459977A5042296530 @default.
• W4362459977 hasAuthorship W4362459977A5042622188 @default.
• W4362459977 hasAuthorship W4362459977A5070691873 @default.
• W4362459977 hasBestOaLocation W43624599771 @default.
• W4362459977 hasConcept C104317684 @default.
• W4362459977 hasConcept C126322002 @default.
• W4362459977 hasConcept C135763542 @default.
• W4362459977 hasConcept C136449434 @default.
• W4362459977 hasConcept C170493617 @default.
• W4362459977 hasConcept C188816634 @default.
• W4362459977 hasConcept C203014093 @default.
• W4362459977 hasConcept C2781236682 @default.
• W4362459977 hasConcept C54355233 @default.
• W4362459977 hasConcept C71924100 @default.
• W4362459977 hasConcept C86803240 @default.
• W4362459977 hasConceptScore W4362459977C104317684 @default.
• W4362459977 hasConceptScore W4362459977C126322002 @default.
• W4362459977 hasConceptScore W4362459977C135763542 @default.
• W4362459977 hasConceptScore W4362459977C136449434 @default.
• W4362459977 hasConceptScore W4362459977C170493617 @default.
• W4362459977 hasConceptScore W4362459977C188816634 @default.
• W4362459977 hasConceptScore W4362459977C203014093 @default.
• W4362459977 hasConceptScore W4362459977C2781236682 @default.
• W4362459977 hasConceptScore W4362459977C54355233 @default.
• W4362459977 hasConceptScore W4362459977C71924100 @default.
• W4362459977 hasConceptScore W4362459977C86803240 @default.
• W4362459977 hasIssue "6" @default.
• W4362459977 hasLocation W43624599771 @default.
• W4362459977 hasLocation W43624599772 @default.
• W4362459977 hasLocation W43624599773 @default.
• W4362459977 hasOpenAccess W4362459977 @default.
• W4362459977 hasPrimaryLocation W43624599771 @default.
• W4362459977 hasRelatedWork W106286926 @default.
• W4362459977 hasRelatedWork W1914689199 @default.
• W4362459977 hasRelatedWork W1921112241 @default.
• W4362459977 hasRelatedWork W1979438498 @default.
• W4362459977 hasRelatedWork W1981462882 @default.
• W4362459977 hasRelatedWork W1997668070 @default.
• W4362459977 hasRelatedWork W2028835724 @default.
• W4362459977 hasRelatedWork W2047730062 @default.
• W4362459977 hasRelatedWork W2103675344 @default.
• W4362459977 hasRelatedWork W2507772654 @default.
• W4362459977 hasVolume "131" @default.
• W4362459977 isParatext "false" @default.
• W4362459977 isRetracted "false" @default.

• next