Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362468082> ?p ?o ?g. }
- W4362468082 abstract "Safe medications for mild mental diseases in pregnancy are needed. Phytomedicines from St. John's wort and valerian are valid candidates, but safety data in pregnancy are lacking. The transplacental transport of hyperforin and hypericin (from St. John's wort), and valerenic acid (from valerian) was evaluated using the ex vivo cotyledon perfusion model (4 h perfusions, term placentae) and, in part, the in vitro Transwell assay with BeWo b30 cells. Antipyrine was used for comparison in both models. U(H)PLC-MS/MS bioanalytical methods were developed to quantify the compounds. Perfusion data obtained with term placentae showed that only minor amounts of hyperforin passed into the fetal circuit, while hypericin did not cross the placental barrier and valerenic acid equilibrated between the maternal and fetal compartments. None of the investigated compounds affected metabolic, functional, and histopathological parameters of the placenta during the perfusion experiments. Data from the Transwell model suggested that valerenic acid does not cross the placental cell layer. Taken together, our data suggest that throughout the pregnancy the potential fetal exposure to hypericin and hyperforin - but not to valerenic acid - is likely to be minimal." @default.
- W4362468082 created "2023-04-05" @default.
- W4362468082 creator A5001796649 @default.
- W4362468082 creator A5006014708 @default.
- W4362468082 creator A5014981447 @default.
- W4362468082 creator A5017252445 @default.
- W4362468082 creator A5017278561 @default.
- W4362468082 creator A5024136407 @default.
- W4362468082 creator A5038636454 @default.
- W4362468082 creator A5046788033 @default.
- W4362468082 creator A5059588429 @default.
- W4362468082 creator A5071540496 @default.
- W4362468082 creator A5084959196 @default.
- W4362468082 date "2023-03-31" @default.
- W4362468082 modified "2023-09-26" @default.
- W4362468082 title "Transplacental passage of hyperforin, hypericin, and valerenic acid" @default.
- W4362468082 cites W110484823 @default.
- W4362468082 cites W128900338 @default.
- W4362468082 cites W1770079579 @default.
- W4362468082 cites W181308150 @default.
- W4362468082 cites W1973563195 @default.
- W4362468082 cites W1973684169 @default.
- W4362468082 cites W1977989261 @default.
- W4362468082 cites W1990771160 @default.
- W4362468082 cites W1992853570 @default.
- W4362468082 cites W2008732658 @default.
- W4362468082 cites W2015342482 @default.
- W4362468082 cites W2020029636 @default.
- W4362468082 cites W2020448183 @default.
- W4362468082 cites W2024866535 @default.
- W4362468082 cites W2033408373 @default.
- W4362468082 cites W2036453518 @default.
- W4362468082 cites W2048758861 @default.
- W4362468082 cites W2057240338 @default.
- W4362468082 cites W2057678450 @default.
- W4362468082 cites W2063078815 @default.
- W4362468082 cites W2069218640 @default.
- W4362468082 cites W2100351408 @default.
- W4362468082 cites W2101212222 @default.
- W4362468082 cites W2108099600 @default.
- W4362468082 cites W2114757573 @default.
- W4362468082 cites W2120137136 @default.
- W4362468082 cites W2120652135 @default.
- W4362468082 cites W2120795379 @default.
- W4362468082 cites W2132717770 @default.
- W4362468082 cites W2146732052 @default.
- W4362468082 cites W2158691121 @default.
- W4362468082 cites W2167802588 @default.
- W4362468082 cites W2169461167 @default.
- W4362468082 cites W2399942170 @default.
- W4362468082 cites W2421355185 @default.
- W4362468082 cites W2434845901 @default.
- W4362468082 cites W2486019732 @default.
- W4362468082 cites W2517000680 @default.
- W4362468082 cites W2750408732 @default.
- W4362468082 cites W2752531028 @default.
- W4362468082 cites W2793076493 @default.
- W4362468082 cites W282673586 @default.
- W4362468082 cites W2899847685 @default.
- W4362468082 cites W2906391364 @default.
- W4362468082 cites W2990980980 @default.
- W4362468082 cites W3042875716 @default.
- W4362468082 cites W3102117775 @default.
- W4362468082 cites W3113779499 @default.
- W4362468082 cites W3141900956 @default.
- W4362468082 cites W3157613556 @default.
- W4362468082 cites W3203733539 @default.
- W4362468082 cites W3206145835 @default.
- W4362468082 cites W4205730626 @default.
- W4362468082 cites W4224296659 @default.
- W4362468082 cites W4283331865 @default.
- W4362468082 cites W786029601 @default.
- W4362468082 doi "https://doi.org/10.3389/fphar.2023.1123194" @default.
- W4362468082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37063288" @default.
- W4362468082 hasPublicationYear "2023" @default.
- W4362468082 type Work @default.
- W4362468082 citedByCount "0" @default.
- W4362468082 crossrefType "journal-article" @default.
- W4362468082 hasAuthorship W4362468082A5001796649 @default.
- W4362468082 hasAuthorship W4362468082A5006014708 @default.
- W4362468082 hasAuthorship W4362468082A5014981447 @default.
- W4362468082 hasAuthorship W4362468082A5017252445 @default.
- W4362468082 hasAuthorship W4362468082A5017278561 @default.
- W4362468082 hasAuthorship W4362468082A5024136407 @default.
- W4362468082 hasAuthorship W4362468082A5038636454 @default.
- W4362468082 hasAuthorship W4362468082A5046788033 @default.
- W4362468082 hasAuthorship W4362468082A5059588429 @default.
- W4362468082 hasAuthorship W4362468082A5071540496 @default.
- W4362468082 hasAuthorship W4362468082A5084959196 @default.
- W4362468082 hasBestOaLocation W43624680821 @default.
- W4362468082 hasConcept C172680121 @default.
- W4362468082 hasConcept C185592680 @default.
- W4362468082 hasConcept C2776651039 @default.
- W4362468082 hasConcept C2776953305 @default.
- W4362468082 hasConcept C2778350159 @default.
- W4362468082 hasConcept C2778432610 @default.
- W4362468082 hasConcept C2779234561 @default.
- W4362468082 hasConcept C2779906218 @default.
- W4362468082 hasConcept C54355233 @default.
- W4362468082 hasConcept C71924100 @default.