Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362470109> ?p ?o ?g. }
- W4362470109 endingPage "1112" @default.
- W4362470109 startingPage "1112" @default.
- W4362470109 abstract "Antisense oligonucleotide (ASO) is a therapeutic modality that enables selective modulation of undruggable protein targets. However, dose- and sequence-dependent platelet count reductions have been reported in nonclinical studies and clinical trials. The adult Göttingen minipig is an acknowledged nonclinical model for ASO safety testing, and the juvenile Göttingen minipig has been recently proposed for the safety testing of pediatric medicines. This study assessed the effects of various ASO sequences and modifications on Göttingen minipig platelets using in vitro platelet activation and aggregometry assays. The underlying mechanism was investigated further to characterize this animal model for ASO safety testing. In addition, the protein abundance of glycoprotein VI (GPVI) and platelet factor 4 (PF4) was investigated in the adult and juvenile minipigs. Our data on direct platelet activation and aggregation by ASOs in adult minipigs are remarkably comparable to human data. Additionally, PS ASOs bind to platelet collagen receptor GPVI and directly activate minipig platelets in vitro, mirroring the findings in human blood samples. This further corroborates the use of the Göttingen minipig for ASO safety testing. Moreover, the differential abundance of GPVI and PF4 in minipigs provides insight into the influence of ontogeny in potential ASO-induced thrombocytopenia in pediatric patients." @default.
- W4362470109 created "2023-04-05" @default.
- W4362470109 creator A5001730952 @default.
- W4362470109 creator A5004498519 @default.
- W4362470109 creator A5032748690 @default.
- W4362470109 creator A5043956841 @default.
- W4362470109 creator A5061629531 @default.
- W4362470109 creator A5063501039 @default.
- W4362470109 creator A5073036123 @default.
- W4362470109 date "2023-03-31" @default.
- W4362470109 modified "2023-10-14" @default.
- W4362470109 title "Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny" @default.
- W4362470109 cites W1595343629 @default.
- W4362470109 cites W1808677409 @default.
- W4362470109 cites W1870321215 @default.
- W4362470109 cites W1940255321 @default.
- W4362470109 cites W1966901891 @default.
- W4362470109 cites W1967084941 @default.
- W4362470109 cites W1973684446 @default.
- W4362470109 cites W1975638599 @default.
- W4362470109 cites W2018492156 @default.
- W4362470109 cites W2024244702 @default.
- W4362470109 cites W2027436660 @default.
- W4362470109 cites W2031988599 @default.
- W4362470109 cites W2033490700 @default.
- W4362470109 cites W2040956921 @default.
- W4362470109 cites W2043969800 @default.
- W4362470109 cites W2050834656 @default.
- W4362470109 cites W2051260415 @default.
- W4362470109 cites W2055167302 @default.
- W4362470109 cites W2065121216 @default.
- W4362470109 cites W2069146205 @default.
- W4362470109 cites W2087560920 @default.
- W4362470109 cites W2088358411 @default.
- W4362470109 cites W2093281895 @default.
- W4362470109 cites W2100947427 @default.
- W4362470109 cites W2104954969 @default.
- W4362470109 cites W2107489987 @default.
- W4362470109 cites W2114775015 @default.
- W4362470109 cites W2118975553 @default.
- W4362470109 cites W2127286930 @default.
- W4362470109 cites W2130886644 @default.
- W4362470109 cites W2134159261 @default.
- W4362470109 cites W2145699974 @default.
- W4362470109 cites W2154236524 @default.
- W4362470109 cites W2163555029 @default.
- W4362470109 cites W2163882430 @default.
- W4362470109 cites W2167408428 @default.
- W4362470109 cites W2318775098 @default.
- W4362470109 cites W2344683948 @default.
- W4362470109 cites W2395658949 @default.
- W4362470109 cites W2416517812 @default.
- W4362470109 cites W2433067092 @default.
- W4362470109 cites W2491658622 @default.
- W4362470109 cites W2496954959 @default.
- W4362470109 cites W25002493 @default.
- W4362470109 cites W2510412860 @default.
- W4362470109 cites W2548894448 @default.
- W4362470109 cites W2581517595 @default.
- W4362470109 cites W2583555090 @default.
- W4362470109 cites W2583673989 @default.
- W4362470109 cites W2599501186 @default.
- W4362470109 cites W2606512239 @default.
- W4362470109 cites W2619533159 @default.
- W4362470109 cites W2691085783 @default.
- W4362470109 cites W2745751687 @default.
- W4362470109 cites W2762135933 @default.
- W4362470109 cites W2767260707 @default.
- W4362470109 cites W2771247031 @default.
- W4362470109 cites W2792025422 @default.
- W4362470109 cites W2805474259 @default.
- W4362470109 cites W2806127886 @default.
- W4362470109 cites W2906081335 @default.
- W4362470109 cites W2936316728 @default.
- W4362470109 cites W2939425449 @default.
- W4362470109 cites W2943158117 @default.
- W4362470109 cites W2980862780 @default.
- W4362470109 cites W3002094750 @default.
- W4362470109 cites W3005929624 @default.
- W4362470109 cites W3006387795 @default.
- W4362470109 cites W3006762655 @default.
- W4362470109 cites W3013945467 @default.
- W4362470109 cites W3023644567 @default.
- W4362470109 cites W3123494922 @default.
- W4362470109 cites W3126189506 @default.
- W4362470109 cites W3141563085 @default.
- W4362470109 cites W3187838163 @default.
- W4362470109 cites W3200470456 @default.
- W4362470109 cites W4226309443 @default.
- W4362470109 cites W4230831374 @default.
- W4362470109 cites W4292088798 @default.
- W4362470109 doi "https://doi.org/10.3390/pharmaceutics15041112" @default.
- W4362470109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37111598" @default.
- W4362470109 hasPublicationYear "2023" @default.
- W4362470109 type Work @default.
- W4362470109 citedByCount "1" @default.
- W4362470109 countsByYear W43624701092023 @default.
- W4362470109 crossrefType "journal-article" @default.