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• W4362470656 abstract "Background Multiple sclerosis (MS) is a lifelong inflammatory and neurodegenerative disease influenced by multiple lifestyle-based factors. Weprovide a tunisianstudy of the effects of modifiable riskfactorsthat are identified as being associated with risk to develop MS and/or influencing the future clinical disease outcomes. Material(s) and Method(s) We conducted a case-control study, including patients from Neurology departement at the Habib Bourguiba hospital (Sfax, Tunisia) whose diagnosis of MS was selected between October 2018 and October 2020.We collected data about their life habits before establishing the diagnosis of MS (smoking, alcoholconsumption, animal husbandry, tendency to saltyfood and physical activity). Result(s) We included 30 MS patients and 30 controls matched according to age and gender. The majority of patients (56.6%) and controls (70%) have never smoked. Alcohol consumption was noted in 2 patients and 4 controls. Besides, the majority of patients and controls had low physical activity with percentages of 80% and 56.6% respectively. Regarding these lifestyle-based factors, we did not highlight any statistically significant differences between patients and controls and there is no impact on the risk of developing MS in ourstudy. Animal husbandry was found in 70% of patients and in 36.7% of controls. We noted that animal husbandry was significantly associated with an increasedrisk of developing MS(OR: 4.03; p=0.01). A salty diet(>12 g/day) was found in 63.3% of patients and 30% of controls. This tendency to salty food was significantly associated with an increased risk of developing MS (OR: 4.03; p=0.01). Conclusion(s) This study identified, among tunisian population, two modifiable risk factors (animal husbandry and salty food) for primary prevention of MS that should inform public health policy. Multiple sclerosis (MS) is a lifelong inflammatory and neurodegenerative disease influenced by multiple lifestyle-based factors. Weprovide a tunisianstudy of the effects of modifiable riskfactorsthat are identified as being associated with risk to develop MS and/or influencing the future clinical disease outcomes. We conducted a case-control study, including patients from Neurology departement at the Habib Bourguiba hospital (Sfax, Tunisia) whose diagnosis of MS was selected between October 2018 and October 2020.We collected data about their life habits before establishing the diagnosis of MS (smoking, alcoholconsumption, animal husbandry, tendency to saltyfood and physical activity). We included 30 MS patients and 30 controls matched according to age and gender. The majority of patients (56.6%) and controls (70%) have never smoked. Alcohol consumption was noted in 2 patients and 4 controls. Besides, the majority of patients and controls had low physical activity with percentages of 80% and 56.6% respectively. Regarding these lifestyle-based factors, we did not highlight any statistically significant differences between patients and controls and there is no impact on the risk of developing MS in ourstudy. Animal husbandry was found in 70% of patients and in 36.7% of controls. We noted that animal husbandry was significantly associated with an increasedrisk of developing MS(OR: 4.03; p=0.01). A salty diet(>12 g/day) was found in 63.3% of patients and 30% of controls. This tendency to salty food was significantly associated with an increased risk of developing MS (OR: 4.03; p=0.01). This study identified, among tunisian population, two modifiable risk factors (animal husbandry and salty food) for primary prevention of MS that should inform public health policy." @default.
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• W4362470656 date "2023-03-01" @default.
• W4362470656 modified "2023-09-30" @default.
• W4362470656 title "Lifestyle and Environmental Factors in Multiple Sclerosis" @default.
• W4362470656 doi "https://doi.org/10.1016/j.msard.2022.104333" @default.
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