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• W4362472902 abstract "Neisseria gonorrhoeae is a Gram-negative aerobic diplococcus bacterium that primarily causes sexually transmitted infections through direct human sexual contact. It is a major public health threat due to its impact on reproductive health, the widespread presence of antimicrobial resistance, and the lack of a vaccine. In this study, we used a bioinformatics approach and performed subtractive genomic methods to identify potential drug targets against the core proteome of N. gonorrhoeae (12 strains). In total, 12,300 protein sequences were retrieved, and paralogous proteins were removed using CD-HIT. The remaining sequences were analyzed for non-homology against the human proteome and gut microbiota, and screened for broad-spectrum analysis, druggability, and anti-target analysis. The proteins were also characterized for unique interactions between the host and pathogen through metabolic pathway analysis. Based on the subtractive genomic approach and subcellular localization, we identified one cytoplasmic protein, 2Fe-2S iron-sulfur cluster binding domain-containing protein (NGFG RS03485), as a potential drug target. This protein could be further exploited for drug development to create new medications and therapeutic agents for the treatment of N. gonorrhoeae infections." @default.
• W4362472902 created "2023-04-05" @default.
• W4362472902 creator A5055896874 @default.
• W4362472902 creator A5059978771 @default.
• W4362472902 date "2023-03-31" @default.
• W4362472902 modified "2023-10-16" @default.
• W4362472902 title "Antibiotic resistance in Neisseria gonorrhoeae: broad-spectrum drug target identification using subtractive genomics" @default.
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• W4362472902 doi "https://doi.org/10.5808/gi.22066" @default.
• W4362472902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37037463" @default.
• W4362472902 hasPublicationYear "2023" @default.
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