Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362475988> ?p ?o ?g. }
- W4362475988 abstract "Abstract The intrinsically disordered region (IDR) of Bim binds to the flexible cryptic site of Bcl-xL, a pro-survival protein involved in cancer progression that plays an important role in initiating apoptosis. However, their binding mechanism has not yet been elucidated. We have applied our dynamic docking protocol, which correctly reproduced both the IDR properties of Bim and the native bound configuration, as well as suggesting other stable/meta-stable binding configurations and revealed the binding pathway. Although the cryptic site of Bcl-xL is predominantly in a closed conformation, initial binding of Bim in an encounter configuration leads to mutual induced-fit binding, where both molecules adapt to each other; Bcl-xL transitions to an open state as Bim folds from a disordered to an α-helical conformation while the two molecules bind each other. Finally, our data provides new avenues to develop novel drugs by targeting newly discovered stable conformations of Bcl-xL." @default.
- W4362475988 created "2023-04-05" @default.
- W4362475988 creator A5023816779 @default.
- W4362475988 creator A5046211758 @default.
- W4362475988 creator A5058425101 @default.
- W4362475988 creator A5065783054 @default.
- W4362475988 creator A5082263981 @default.
- W4362475988 date "2023-03-30" @default.
- W4362475988 modified "2023-10-09" @default.
- W4362475988 title "Mutual induced-fit mechanism drives binding between intrinsically disordered Bim and cryptic binding site of Bcl-xL" @default.
- W4362475988 cites W1607931568 @default.
- W4362475988 cites W1835922068 @default.
- W4362475988 cites W1948576518 @default.
- W4362475988 cites W1965217295 @default.
- W4362475988 cites W1976499671 @default.
- W4362475988 cites W1981225934 @default.
- W4362475988 cites W1990372288 @default.
- W4362475988 cites W1991213319 @default.
- W4362475988 cites W2008708467 @default.
- W4362475988 cites W2014985938 @default.
- W4362475988 cites W2017991274 @default.
- W4362475988 cites W2018786413 @default.
- W4362475988 cites W2022298113 @default.
- W4362475988 cites W2022821237 @default.
- W4362475988 cites W2023940150 @default.
- W4362475988 cites W2047580257 @default.
- W4362475988 cites W2049172807 @default.
- W4362475988 cites W2057477511 @default.
- W4362475988 cites W2059013803 @default.
- W4362475988 cites W2062692230 @default.
- W4362475988 cites W2063176993 @default.
- W4362475988 cites W2066690664 @default.
- W4362475988 cites W2085419794 @default.
- W4362475988 cites W2086086905 @default.
- W4362475988 cites W2088883749 @default.
- W4362475988 cites W2103945336 @default.
- W4362475988 cites W2106799894 @default.
- W4362475988 cites W2117692326 @default.
- W4362475988 cites W2118998349 @default.
- W4362475988 cites W2123529526 @default.
- W4362475988 cites W2124221273 @default.
- W4362475988 cites W2161605421 @default.
- W4362475988 cites W2265102996 @default.
- W4362475988 cites W2404280981 @default.
- W4362475988 cites W2513379522 @default.
- W4362475988 cites W2517814100 @default.
- W4362475988 cites W2543839061 @default.
- W4362475988 cites W2589060305 @default.
- W4362475988 cites W2613003159 @default.
- W4362475988 cites W2747261161 @default.
- W4362475988 cites W2754181811 @default.
- W4362475988 cites W2770371168 @default.
- W4362475988 cites W2781564573 @default.
- W4362475988 cites W2886639208 @default.
- W4362475988 cites W2900311838 @default.
- W4362475988 cites W2915232951 @default.
- W4362475988 cites W2921063431 @default.
- W4362475988 cites W2921098500 @default.
- W4362475988 cites W3003657470 @default.
- W4362475988 cites W3005171368 @default.
- W4362475988 cites W3014394487 @default.
- W4362475988 cites W3090277034 @default.
- W4362475988 cites W3097394854 @default.
- W4362475988 cites W3102022293 @default.
- W4362475988 cites W3127174575 @default.
- W4362475988 cites W3134762652 @default.
- W4362475988 cites W3136571708 @default.
- W4362475988 cites W3177828909 @default.
- W4362475988 cites W3195375135 @default.
- W4362475988 cites W3201091795 @default.
- W4362475988 cites W3206116958 @default.
- W4362475988 cites W3216612932 @default.
- W4362475988 cites W4308584246 @default.
- W4362475988 cites W4309388017 @default.
- W4362475988 doi "https://doi.org/10.1038/s42003-023-04720-6" @default.
- W4362475988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36997643" @default.
- W4362475988 hasPublicationYear "2023" @default.
- W4362475988 type Work @default.
- W4362475988 citedByCount "2" @default.
- W4362475988 countsByYear W43624759882023 @default.
- W4362475988 crossrefType "journal-article" @default.
- W4362475988 hasAuthorship W4362475988A5023816779 @default.
- W4362475988 hasAuthorship W4362475988A5046211758 @default.
- W4362475988 hasAuthorship W4362475988A5058425101 @default.
- W4362475988 hasAuthorship W4362475988A5065783054 @default.
- W4362475988 hasAuthorship W4362475988A5082263981 @default.
- W4362475988 hasBestOaLocation W43624759881 @default.
- W4362475988 hasConcept C107824862 @default.
- W4362475988 hasConcept C121332964 @default.
- W4362475988 hasConcept C12554922 @default.
- W4362475988 hasConcept C159110408 @default.
- W4362475988 hasConcept C161624437 @default.
- W4362475988 hasConcept C185592680 @default.
- W4362475988 hasConcept C190283241 @default.
- W4362475988 hasConcept C2776789625 @default.
- W4362475988 hasConcept C31573885 @default.
- W4362475988 hasConcept C41685203 @default.
- W4362475988 hasConcept C51639874 @default.
- W4362475988 hasConcept C55493867 @default.
- W4362475988 hasConcept C62520636 @default.