Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362478059> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4362478059 abstract "<div>Abstract<p>Protein phosphatase 2A (PP2A) is a tumor suppressor that regulates many signaling pathways crucial for cell transformation. In fact, decreased activity of PP2A has been reported as a recurrent alteration in many types of cancer. Here, we show that PP2A is frequently inactivated in patients with colorectal cancer, indicating that PP2A represents a potential therapeutic target for this disease. We identified overexpression of the endogenous PP2A inhibitors SET and CIP2A, and downregulation of regulatory PP2A such as PPP2R2A and PPP2R5E, as contributing mechanisms to PP2A inhibition in colorectal cancer. Moreover, we observed that its restoration using FTY720 impairs proliferation and clonogenic potential of colorectal cancer cells, induces caspase-dependent apoptosis, and affects AKT and extracellular signal-regulated kinase-1/2 activation status. Interestingly, treatment with FTY720 showed an additive effect with 5-fluorouracil, SN-38, and oxaliplatin, drugs used in standard chemotherapy in patients with colorectal cancer. These results suggest that PP2A activity is commonly decreased in colorectal cancer cells, and that the use of PP2A activators, such as FTY720, might represent a potential novel therapeutic strategy in colorectal cancer. <i>Mol Cancer Ther; 13(4); 938–47. ©2014 AACR</i>.</p></div>" @default.
- W4362478059 created "2023-04-05" @default.
- W4362478059 creator A5006108242 @default.
- W4362478059 creator A5010683740 @default.
- W4362478059 creator A5012974257 @default.
- W4362478059 creator A5013095504 @default.
- W4362478059 creator A5031404036 @default.
- W4362478059 creator A5031537332 @default.
- W4362478059 creator A5037452001 @default.
- W4362478059 creator A5042786845 @default.
- W4362478059 creator A5071876543 @default.
- W4362478059 creator A5075463200 @default.
- W4362478059 creator A5080075925 @default.
- W4362478059 creator A5085212326 @default.
- W4362478059 creator A5090505952 @default.
- W4362478059 date "2023-04-03" @default.
- W4362478059 modified "2023-09-24" @default.
- W4362478059 title "Data from PP2A Inhibition Is a Common Event in Colorectal Cancer and Its Restoration Using FTY720 Shows Promising Therapeutic Potential" @default.
- W4362478059 doi "https://doi.org/10.1158/1535-7163.c.6536193.v1" @default.
- W4362478059 hasPublicationYear "2023" @default.
- W4362478059 type Work @default.
- W4362478059 citedByCount "0" @default.
- W4362478059 crossrefType "posted-content" @default.
- W4362478059 hasAuthorship W4362478059A5006108242 @default.
- W4362478059 hasAuthorship W4362478059A5010683740 @default.
- W4362478059 hasAuthorship W4362478059A5012974257 @default.
- W4362478059 hasAuthorship W4362478059A5013095504 @default.
- W4362478059 hasAuthorship W4362478059A5031404036 @default.
- W4362478059 hasAuthorship W4362478059A5031537332 @default.
- W4362478059 hasAuthorship W4362478059A5037452001 @default.
- W4362478059 hasAuthorship W4362478059A5042786845 @default.
- W4362478059 hasAuthorship W4362478059A5071876543 @default.
- W4362478059 hasAuthorship W4362478059A5075463200 @default.
- W4362478059 hasAuthorship W4362478059A5080075925 @default.
- W4362478059 hasAuthorship W4362478059A5085212326 @default.
- W4362478059 hasAuthorship W4362478059A5090505952 @default.
- W4362478059 hasBestOaLocation W43624780592 @default.
- W4362478059 hasConcept C104317684 @default.
- W4362478059 hasConcept C111669997 @default.
- W4362478059 hasConcept C117262875 @default.
- W4362478059 hasConcept C11960822 @default.
- W4362478059 hasConcept C121608353 @default.
- W4362478059 hasConcept C126322002 @default.
- W4362478059 hasConcept C127561419 @default.
- W4362478059 hasConcept C178666793 @default.
- W4362478059 hasConcept C185592680 @default.
- W4362478059 hasConcept C190283241 @default.
- W4362478059 hasConcept C2780962732 @default.
- W4362478059 hasConcept C2781018059 @default.
- W4362478059 hasConcept C29537977 @default.
- W4362478059 hasConcept C389152 @default.
- W4362478059 hasConcept C502942594 @default.
- W4362478059 hasConcept C526805850 @default.
- W4362478059 hasConcept C55493867 @default.
- W4362478059 hasConcept C71924100 @default.
- W4362478059 hasConcept C75217442 @default.
- W4362478059 hasConcept C86803240 @default.
- W4362478059 hasConcept C95444343 @default.
- W4362478059 hasConcept C96232424 @default.
- W4362478059 hasConceptScore W4362478059C104317684 @default.
- W4362478059 hasConceptScore W4362478059C111669997 @default.
- W4362478059 hasConceptScore W4362478059C117262875 @default.
- W4362478059 hasConceptScore W4362478059C11960822 @default.
- W4362478059 hasConceptScore W4362478059C121608353 @default.
- W4362478059 hasConceptScore W4362478059C126322002 @default.
- W4362478059 hasConceptScore W4362478059C127561419 @default.
- W4362478059 hasConceptScore W4362478059C178666793 @default.
- W4362478059 hasConceptScore W4362478059C185592680 @default.
- W4362478059 hasConceptScore W4362478059C190283241 @default.
- W4362478059 hasConceptScore W4362478059C2780962732 @default.
- W4362478059 hasConceptScore W4362478059C2781018059 @default.
- W4362478059 hasConceptScore W4362478059C29537977 @default.
- W4362478059 hasConceptScore W4362478059C389152 @default.
- W4362478059 hasConceptScore W4362478059C502942594 @default.
- W4362478059 hasConceptScore W4362478059C526805850 @default.
- W4362478059 hasConceptScore W4362478059C55493867 @default.
- W4362478059 hasConceptScore W4362478059C71924100 @default.
- W4362478059 hasConceptScore W4362478059C75217442 @default.
- W4362478059 hasConceptScore W4362478059C86803240 @default.
- W4362478059 hasConceptScore W4362478059C95444343 @default.
- W4362478059 hasConceptScore W4362478059C96232424 @default.
- W4362478059 hasLocation W43624780591 @default.
- W4362478059 hasLocation W43624780592 @default.
- W4362478059 hasOpenAccess W4362478059 @default.
- W4362478059 hasPrimaryLocation W43624780591 @default.
- W4362478059 hasRelatedWork W2065289988 @default.
- W4362478059 hasRelatedWork W2078377364 @default.
- W4362478059 hasRelatedWork W2082661266 @default.
- W4362478059 hasRelatedWork W2139836283 @default.
- W4362478059 hasRelatedWork W2580029392 @default.
- W4362478059 hasRelatedWork W2594356097 @default.
- W4362478059 hasRelatedWork W2807613378 @default.
- W4362478059 hasRelatedWork W3045868324 @default.
- W4362478059 hasRelatedWork W3116400448 @default.
- W4362478059 hasRelatedWork W4362478059 @default.
- W4362478059 isParatext "false" @default.
- W4362478059 isRetracted "false" @default.
- W4362478059 workType "article" @default.