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- W4362479040 abstract "<div>Abstract<p>A novel <i>TRIM</i> family member, <i>TRIM</i>59 gene was characterized to be upregulated in SV40 Tag oncogene–directed transgenic and knockout mouse prostate cancer models as a signaling pathway effector. We identified two phosphorylated forms of <i>TRIM</i>59 (p53 and p55) and characterized them using purified TRIM59 proteins from mouse prostate cancer models at different stages with wild-type mice and NIH3T3 cells as controls. p53/p55-TRIM59 proteins possibly represent Ser/Thr and Tyr phosphorylation modifications, respectively. Quantitative measurements by ELISA showed that the p-Ser/Thr TRIM59 correlated with tumorigenesis, whereas the p-Tyr-TRIM59 protein correlated with advanced cancer of the prostate (CaP). The function of <i>TRIM</i>59 was elucidated using short hairpin RNA (shRNA)-mediated knockdown of the gene in human CaP cells, which caused S-phase cell-cycle arrest and cell growth retardation. A hit-and-run effect of <i>TRIM</i>59 shRNA knockdown was observed 24 hours posttransfection. Differential cDNA microarrray analysis was conducted, which showed that the initial and rapid knockdown occurred early in the Ras signaling pathway. To confirm the proto-oncogenic function of <i>TRIM</i>59 in the Ras signaling pathway, we generated a transgenic mouse model using a prostate tissue–specific gene (<i>PSP94</i>) to direct the upregulation of the <i>TRIM59</i> gene. Restricted <i>TRIM59</i> gene upregulation in the prostate revealed the full potential for inducing tumorigenesis, similar to the expression of SV40 Tag, and coincided with the upregulation of genes specific to the Ras signaling pathway and bridging genes for SV40 Tag–mediated oncogenesis. The finding of a possible novel oncogene in animal models will implicate a novel strategy for diagnosis, prognosis, and therapy for cancer. <i>Mol Cancer Ther; 10(7); 1229–40. ©2011 AACR</i>.</p></div>" @default.
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- W4362479040 date "2023-04-03" @default.
- W4362479040 modified "2023-10-01" @default.
- W4362479040 title "Data from Characterization of the Oncogenic Activity of the Novel <i>TRIM59</i> Gene in Mouse Cancer Models" @default.
- W4362479040 doi "https://doi.org/10.1158/1535-7163.c.6535443" @default.
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