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- W4362480510 abstract "<div>Abstract<p>Glucobrassicin in <i>Brassica</i> vegetables gives rise to indole-3-carbinol (I3C), a compound with potent anticancer effects in preclinical models. We previously showed that the urinary metabolite 3,3′-diindolylmethane (DIM) could discriminate between volunteers fed high and low doses of <i>Brassica</i> vegetables. However, the quantitative relationship between glucobrassicin exposure and urinary DIM level is unclear. We conducted a clinical trial to examine the hypotheses that a range of glucobrassicin exposure from <i>Brassica</i> vegetables is reflected in urinary DIM and that this effect plateaus. Forty-five subjects consumed vegetables, a mixture of brussels sprouts and/or cabbage, at one of seven discrete dose levels of glucobrassicin ranging from 25 to 500 μmol, once daily for 2 consecutive days. All urine was collected for 24 hours after each vegetable-eating session. Urinary DIM was measured using our published liquid chromatography-electrospray ionization-tandem mass spectrometry-selected reaction monitoring (LC/ESI-MS/MS-SRM) method. Urinary DIM excretion increased predictably with increasing glucobrassicin dose and plateaued between 200 and 300 μmol of glucobrassicin. The association between glucobrassicin dose and urinary DIM was strong and positive (<i>R</i><sup>2</sup> = 0.68). The majority of DIM was excreted in the first 12 hours after vegetable consumption. We conclude that urinary DIM is a reliable biomarker of glucobrassicin exposure and I3C uptake and that feeding glucobrassicin beyond 200 μmol did not consistently lead to more urinary DIM, suggesting a plateau in potential chemopreventive benefit. <i>Cancer Prev Res; 9(10); 788–93. ©2016 AACR</i>.</p></div>" @default.
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- W4362480510 date "2023-04-03" @default.
- W4362480510 modified "2023-09-29" @default.
- W4362480510 title "Data from Harnessing the Power of Cruciferous Vegetables: Developing a Biomarker for <i>Brassica</i> Vegetable Consumption Using Urinary 3,3′-Diindolylmethane" @default.
- W4362480510 doi "https://doi.org/10.1158/1940-6207.c.6547124.v1" @default.
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