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• W4362481118 abstract "<div>Abstract<p>We evaluated the safety and activity of autologous T cells expressing NY-ESO-1^c259, an affinity-enhanced T-cell receptor (TCR) recognizing an HLA-A2–restricted NY-ESO-1/LAGE1a–derived peptide, in patients with metastatic synovial sarcoma (NY-ESO-1^c259T cells). Confirmed antitumor responses occurred in 50% of patients (6/12) and were characterized by tumor shrinkage over several months. Circulating NY-ESO-1^c259T cells were present postinfusion in all patients and persisted for at least 6 months in all responders. Most of the infused NY-ESO-1^c259T cells exhibited an effector memory phenotype following <i>ex vivo</i> expansion, but the persisting pools comprised largely central memory and stem-cell memory subsets, which remained polyfunctional and showed no evidence of T-cell exhaustion despite persistent tumor burdens. Next-generation sequencing of endogenous TCRs in CD8⁺ NY-ESO-1^c259T cells revealed clonal diversity without contraction over time. These data suggest that regenerative pools of NY-ESO-1^c259T cells produced a continuing supply of effector cells to mediate sustained, clinically meaningful antitumor effects.</p><p><b>Significance:</b> Metastatic synovial sarcoma is incurable with standard therapy. We employed engineered T cells targeting NY-ESO-1, and the data suggest that robust, self-regenerating pools of CD8⁺ NY-ESO-1^c259T cells produce a continuing supply of effector cells over several months that mediate clinically meaningful antitumor effects despite prolonged exposure to antigen. <i>Cancer Discov; 8(8); 944–57. ©2018 AACR.</i></p><p><i>See related commentary by Keung and Tawbi, p. 914</i>.</p><p><i>This article is highlighted in the In This Issue feature, p. 899</i></p></div>" @default.
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• W4362481118 date "2023-04-03" @default.
• W4362481118 modified "2023-09-27" @default.
• W4362481118 title "Data from Antitumor Activity Associated with Prolonged Persistence of Adoptively Transferred NY-ESO-1 ^c259T Cells in Synovial Sarcoma" @default.
• W4362481118 doi "https://doi.org/10.1158/2159-8290.c.6546836.v1" @default.
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