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- W4362485364 abstract "<div>Abstract<p>Basal cell carcinoma (BCC) is the most common human cancer. We have demonstrated previously that topical application of the retinoid prodrug tazarotene profoundly inhibits murine BCC carcinogenesis via retinoic acid receptor γ–mediated regulation of tumor cell transcription. Because topical retinoids can cause adverse cutaneous effects and because tumors can develop resistance to retinoids, we have investigated mechanisms downstream of tazarotene's antitumor effect in this model. Specifically we have used (i) global expression profiling to <i>identify</i> and (ii) functional cell-based assays to <i>validate</i> the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway as a downstream target pathway of tazarotene's action. Crucially, we have demonstrated that pharmacologic inhibition of this downstream pathway profoundly reduces murine BCC cell proliferation and tumorigenesis both <i>in vitro</i> and <i>in vivo</i>. These data identify PI3K/AKT/mTOR signaling as a highly attractive target for BCC chemoprevention and indicate more generally that this pathway may be, in some contexts, an important mediator of retinoid anticancer effects. <i>Cancer Prev Res; 7(4); 407–17. ©2014 AACR</i>.</p></div>" @default.
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- W4362485364 date "2023-04-03" @default.
- W4362485364 modified "2023-09-27" @default.
- W4362485364 title "Data from PI3K-AKT Signaling Is a Downstream Effector of Retinoid Prevention of Murine Basal Cell Carcinogenesis" @default.
- W4362485364 doi "https://doi.org/10.1158/1940-6207.c.6544302" @default.
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