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- W4362486281 abstract "<div>Abstract<p><i>Helicobacter pylori</i> (<i>H. pylori</i>) infection induces a chronic inflammatory response, which promotes gastric carcinogenesis. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) plays a key role as a tumor suppressor in gastrointestinal cancers. The aim of this study was to elucidate the role of 15-PGDH in gastric carcinogenesis associated with <i>H. pylori</i>. 15-PGDH expression in gastric biopsies from <i>H. pylori</i>–infected (<i>n</i> = 25) and noninfected (<i>n</i> = 15) subjects was analyzed by quantitative real-time PCR, Western blot analysis, and immunohistochemistry. 15-PGDH DNA methylation was evaluated by methylation-specific PCR and pyrosequencing. The expression of 15-PGDH, Snail, extracellular signal–regulated kinase (ERK)1/2, TLR4, and MyD88 in response to <i>H. pylori</i> infection was assessed by immunoblot analysis. Compared with negative specimens, <i>H. pylori</i>–positive specimens had 2-fold lower 15-PGDH mRNA levels and significantly less 15-PGDH protein. In four <i>H. pylori–</i>infected subjects with longitudinal follow-up, the suppression of 15-PGDH expression was reversed by <i>H. pylori</i> eradication therapy. In parallel with suppressing 15-PGDH expression, <i>H. pylori</i> infection activated expression of TLR4 and MyD88 expression, increased levels of phospho-ERK1/2, and increased expression of EGF receptor (EGFR)-Snail. Inhibition of Snail and MyD88 reversed suppression of 15-PGDH expression, and siMyD88 reduced phosphorylated ERK1/2. Similarly, treatment with an ERK1/2 and EGFR inhibitor also restored 15-PGDH expression. <i>H. pylori</i> appeared to promote gastric carcinogenesis by suppressing15-PGDH. This process is mediated by the TLR4/MyD88 pathway via ERK1/2 or EGFR-Snail transcriptional regulation. 15-PGDH may be a useful marker and a potential therapeutic target in <i>H. pylori</i>–induced gastric carcinogenesis. <i>Cancer Prev Res; 6(4); 349–59. ©2013 AACR.</i></p></div>" @default.
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- W4362486281 date "2023-04-03" @default.
- W4362486281 modified "2023-10-12" @default.
- W4362486281 title "Data from Inhibition of 15-Hydroxyprostaglandin Dehydrogenase by <i>Helicobacter pylori</i> in Human Gastric Carcinogenesis" @default.
- W4362486281 doi "https://doi.org/10.1158/1940-6207.c.6543597.v1" @default.
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