FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362488586> ?p ?o ?g. }

• W4362488586 abstract "<div>Abstract<p>Ovarian cancer is a diverse class of tumors with very few effective treatment options and suboptimal response rates in early clinical studies using immunotherapies. Here we describe LY6/PLAUR domain containing 1 (LYPD1) as a novel target for therapeutic antibodies for the treatment of ovarian cancer. LYPD1 is broadly expressed in both primary and metastatic ovarian cancer with ∼70% prevalence in the serous cancer subset. Bispecific antibodies targeting CD3 on T cells and a tumor antigen on cancer cells have demonstrated significant clinical activity in hematologic cancers. We have developed an anti-LYPD1/CD3 T-cell-dependent bispecific antibody (TDB) to redirect T-cell responses to LYPD1 expressing ovarian cancer. Here we characterize the nonclinical pharmacology of anti-LYPD1/CD3 TDB and show induction of a robust polyclonal T-cell activation and target dependent killing of LYPD1 expressing ovarian cancer cells resulting in efficient <i>in vivo</i> antitumor responses in PBMC reconstituted immune-deficient mice and human CD3 transgenic mouse models. Anti-LYPD1/CD3 TDB is generally well tolerated at high-dose levels in mice, a pharmacologically relevant species, and showed no evidence of toxicity or damage to LYPD1 expressing tissues.</p></div>" @default.
• W4362488586 created "2023-04-05" @default.
• W4362488586 creator A5000942609 @default.
• W4362488586 creator A5003498756 @default.
• W4362488586 creator A5003793672 @default.
• W4362488586 creator A5005960200 @default.
• W4362488586 creator A5009606169 @default.
• W4362488586 creator A5009750272 @default.
• W4362488586 creator A5017772219 @default.
• W4362488586 creator A5023967455 @default.
• W4362488586 creator A5027055222 @default.
• W4362488586 creator A5042302638 @default.
• W4362488586 creator A5044228668 @default.
• W4362488586 creator A5045513613 @default.
• W4362488586 creator A5046256348 @default.
• W4362488586 creator A5057332639 @default.
• W4362488586 creator A5064803348 @default.
• W4362488586 creator A5065415147 @default.
• W4362488586 creator A5066448768 @default.
• W4362488586 creator A5066781940 @default.
• W4362488586 creator A5067027064 @default.
• W4362488586 creator A5069163885 @default.
• W4362488586 creator A5069234901 @default.
• W4362488586 creator A5069386716 @default.
• W4362488586 creator A5087559939 @default.
• W4362488586 creator A5091020213 @default.
• W4362488586 date "2023-04-03" @default.
• W4362488586 modified "2023-10-03" @default.
• W4362488586 title "Data from Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer" @default.
• W4362488586 doi "https://doi.org/10.1158/1535-7163.c.6543427" @default.
• W4362488586 hasPublicationYear "2023" @default.
• W4362488586 type Work @default.
• W4362488586 citedByCount "0" @default.
• W4362488586 crossrefType "posted-content" @default.
• W4362488586 hasAuthorship W4362488586A5000942609 @default.
• W4362488586 hasAuthorship W4362488586A5003498756 @default.
• W4362488586 hasAuthorship W4362488586A5003793672 @default.
• W4362488586 hasAuthorship W4362488586A5005960200 @default.
• W4362488586 hasAuthorship W4362488586A5009606169 @default.
• W4362488586 hasAuthorship W4362488586A5009750272 @default.
• W4362488586 hasAuthorship W4362488586A5017772219 @default.
• W4362488586 hasAuthorship W4362488586A5023967455 @default.
• W4362488586 hasAuthorship W4362488586A5027055222 @default.
• W4362488586 hasAuthorship W4362488586A5042302638 @default.
• W4362488586 hasAuthorship W4362488586A5044228668 @default.
• W4362488586 hasAuthorship W4362488586A5045513613 @default.
• W4362488586 hasAuthorship W4362488586A5046256348 @default.
• W4362488586 hasAuthorship W4362488586A5057332639 @default.
• W4362488586 hasAuthorship W4362488586A5064803348 @default.
• W4362488586 hasAuthorship W4362488586A5065415147 @default.
• W4362488586 hasAuthorship W4362488586A5066448768 @default.
• W4362488586 hasAuthorship W4362488586A5066781940 @default.
• W4362488586 hasAuthorship W4362488586A5067027064 @default.
• W4362488586 hasAuthorship W4362488586A5069163885 @default.
• W4362488586 hasAuthorship W4362488586A5069234901 @default.
• W4362488586 hasAuthorship W4362488586A5069386716 @default.
• W4362488586 hasAuthorship W4362488586A5087559939 @default.
• W4362488586 hasAuthorship W4362488586A5091020213 @default.
• W4362488586 hasBestOaLocation W43624885862 @default.
• W4362488586 hasConcept C114684123 @default.
• W4362488586 hasConcept C121608353 @default.
• W4362488586 hasConcept C126322002 @default.
• W4362488586 hasConcept C147483822 @default.
• W4362488586 hasConcept C150903083 @default.
• W4362488586 hasConcept C159654299 @default.
• W4362488586 hasConcept C167672396 @default.
• W4362488586 hasConcept C203014093 @default.
• W4362488586 hasConcept C207001950 @default.
• W4362488586 hasConcept C2776090121 @default.
• W4362488586 hasConcept C2780427987 @default.
• W4362488586 hasConcept C502942594 @default.
• W4362488586 hasConcept C71924100 @default.
• W4362488586 hasConcept C86803240 @default.
• W4362488586 hasConcept C8891405 @default.
• W4362488586 hasConcept C956191 @default.
• W4362488586 hasConcept C96232424 @default.
• W4362488586 hasConceptScore W4362488586C114684123 @default.
• W4362488586 hasConceptScore W4362488586C121608353 @default.
• W4362488586 hasConceptScore W4362488586C126322002 @default.
• W4362488586 hasConceptScore W4362488586C147483822 @default.
• W4362488586 hasConceptScore W4362488586C150903083 @default.
• W4362488586 hasConceptScore W4362488586C159654299 @default.
• W4362488586 hasConceptScore W4362488586C167672396 @default.
• W4362488586 hasConceptScore W4362488586C203014093 @default.
• W4362488586 hasConceptScore W4362488586C207001950 @default.
• W4362488586 hasConceptScore W4362488586C2776090121 @default.
• W4362488586 hasConceptScore W4362488586C2780427987 @default.
• W4362488586 hasConceptScore W4362488586C502942594 @default.
• W4362488586 hasConceptScore W4362488586C71924100 @default.
• W4362488586 hasConceptScore W4362488586C86803240 @default.
• W4362488586 hasConceptScore W4362488586C8891405 @default.
• W4362488586 hasConceptScore W4362488586C956191 @default.
• W4362488586 hasConceptScore W4362488586C96232424 @default.
• W4362488586 hasLocation W43624885861 @default.
• W4362488586 hasLocation W43624885862 @default.
• W4362488586 hasOpenAccess W4362488586 @default.
• W4362488586 hasPrimaryLocation W43624885861 @default.
• W4362488586 hasRelatedWork W1484759019 @default.
• W4362488586 hasRelatedWork W2020042598 @default.
• W4362488586 hasRelatedWork W2022815666 @default.

• next