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- W4362488778 abstract "<p>The process of platelet production. In bone marrow, all hematopoietic progenitors are derived from hematopoietic stem cells (HSCs). Platelets gradually differentiate from HSCs. HSCs first differentiate into the common myeloid progenitor cells (CMPs) and common lymphoid progenitor cells (CLPs). CMPs further differentiate into granulocyte/macrophage progenitor cells (GMPs) and megakaryocyte-erythrocyte progenitor cells (MEPs). MEPs then differentiate into MK precursor cells and red blood cells. MK precursor cells need to go through a maturation process before shedding platelets. In this process, although the ability to divide is lost, DNA replication and cytoplasmic maturation (including the rearrangement of the cytoplasmic skeleton and the formation of pseudopodia) are maintained. After maturation, MKs are arranged adjacent to vascular endothelial cells, forming platelet precursors and releasing platelets into circulation.</p>" @default.
- W4362488778 created "2023-04-05" @default.
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- W4362488778 date "2023-04-03" @default.
- W4362488778 modified "2023-09-29" @default.
- W4362488778 title "Figure S1 from New Insights Into Platelet-enriched miRNAs: Production, Functions, Roles in Tumors, and Potential Targets for Tumor Diagnosis and Treatment" @default.
- W4362488778 doi "https://doi.org/10.1158/1535-7163.22522378" @default.
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