FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362490411> ?p ?o ?g. }

• W4362490411 abstract "<div>Abstract<p>Despite existing chemotherapy and surgical resection strategies, pancreatic cancer is one of the major causes of mortality in the United States with a 5-year mean survival rate of less than 5%. The activation of the urokinase-type plasminogen activator receptor–urokinase-type plasminogen activator (uPAR–uPA) system in the development of pancreatic ductal adenocarcinoma has been well established. In the present study, we used 2 pancreatic cancer cell lines, MIA PaCa-2 and PANC-1 to show the effects of uPAR and uPA downregulation. From the results, we observed that RNAi expressing plasmids efficiently downregulated mRNA and protein expression of uPAR and uPA. <i>In vitro</i> and <i>in vivo</i> angiogenic assays revealed a significant decrease in the angiogenic potential of MIA PaCa-2 and PANC-1 cells that were downregulated for both uPAR and uPA. From the angiogenesis antibody array analysis, we observed that the simultaneous downregulation of uPAR and uPA resulted in the downregulation of angiogenin and overexpression of RANTES. Further, FACS analysis showed that the simultaneous downregulation of uPAR and uPA caused the accumulation of cells in the sub-G_0/1 phase in both MIA PaCa-2 and PANC-1 cells. In addition, Western blot analysis revealed that downregulation of uPAR and uPA caused the activation of caspase 8 and CAD, which is indicative of apoptosis, and <i>in vivo</i> TUNEL assay confirmed these results. Finally, we observed the nuclear localization of uPA and that uPA interacts with the transcription factor Lhx-2. Taken together, the results of the present study show that the targeting of the uPAR–uPA system has therapeutic potential. <i>Mol Cancer Res; 9(4); 377–89. ©2011 AACR</i>.</p></div>" @default.
• W4362490411 created "2023-04-05" @default.
• W4362490411 creator A5010176744 @default.
• W4362490411 creator A5012539225 @default.
• W4362490411 creator A5047795571 @default.
• W4362490411 creator A5063197597 @default.
• W4362490411 creator A5071514249 @default.
• W4362490411 date "2023-04-03" @default.
• W4362490411 modified "2023-10-01" @default.
• W4362490411 title "Data from Suppression of the uPAR–uPA System Retards Angiogenesis, Invasion, and <i>In Vivo</i> Tumor Development in Pancreatic Cancer Cells" @default.
• W4362490411 doi "https://doi.org/10.1158/1541-7786.c.6542290.v1" @default.
• W4362490411 hasPublicationYear "2023" @default.
• W4362490411 type Work @default.
• W4362490411 citedByCount "0" @default.
• W4362490411 crossrefType "posted-content" @default.
• W4362490411 hasAuthorship W4362490411A5010176744 @default.
• W4362490411 hasAuthorship W4362490411A5012539225 @default.
• W4362490411 hasAuthorship W4362490411A5047795571 @default.
• W4362490411 hasAuthorship W4362490411A5063197597 @default.
• W4362490411 hasAuthorship W4362490411A5071514249 @default.
• W4362490411 hasConcept C104317684 @default.
• W4362490411 hasConcept C121608353 @default.
• W4362490411 hasConcept C126322002 @default.
• W4362490411 hasConcept C127561419 @default.
• W4362490411 hasConcept C134018914 @default.
• W4362490411 hasConcept C150903083 @default.
• W4362490411 hasConcept C153911025 @default.
• W4362490411 hasConcept C185592680 @default.
• W4362490411 hasConcept C207001950 @default.
• W4362490411 hasConcept C2779679481 @default.
• W4362490411 hasConcept C2780210213 @default.
• W4362490411 hasConcept C2780394083 @default.
• W4362490411 hasConcept C502942594 @default.
• W4362490411 hasConcept C55493867 @default.
• W4362490411 hasConcept C56219504 @default.
• W4362490411 hasConcept C71924100 @default.
• W4362490411 hasConcept C86803240 @default.
• W4362490411 hasConceptScore W4362490411C104317684 @default.
• W4362490411 hasConceptScore W4362490411C121608353 @default.
• W4362490411 hasConceptScore W4362490411C126322002 @default.
• W4362490411 hasConceptScore W4362490411C127561419 @default.
• W4362490411 hasConceptScore W4362490411C134018914 @default.
• W4362490411 hasConceptScore W4362490411C150903083 @default.
• W4362490411 hasConceptScore W4362490411C153911025 @default.
• W4362490411 hasConceptScore W4362490411C185592680 @default.
• W4362490411 hasConceptScore W4362490411C207001950 @default.
• W4362490411 hasConceptScore W4362490411C2779679481 @default.
• W4362490411 hasConceptScore W4362490411C2780210213 @default.
• W4362490411 hasConceptScore W4362490411C2780394083 @default.
• W4362490411 hasConceptScore W4362490411C502942594 @default.
• W4362490411 hasConceptScore W4362490411C55493867 @default.
• W4362490411 hasConceptScore W4362490411C56219504 @default.
• W4362490411 hasConceptScore W4362490411C71924100 @default.
• W4362490411 hasConceptScore W4362490411C86803240 @default.
• W4362490411 hasLocation W43624904111 @default.
• W4362490411 hasOpenAccess W4362490411 @default.
• W4362490411 hasPrimaryLocation W43624904111 @default.
• W4362490411 hasRelatedWork W1576290062 @default.
• W4362490411 hasRelatedWork W1599186952 @default.
• W4362490411 hasRelatedWork W1973679005 @default.
• W4362490411 hasRelatedWork W2049999422 @default.
• W4362490411 hasRelatedWork W2058903925 @default.
• W4362490411 hasRelatedWork W2115162283 @default.
• W4362490411 hasRelatedWork W2158089750 @default.
• W4362490411 hasRelatedWork W2283698778 @default.
• W4362490411 hasRelatedWork W4361944887 @default.
• W4362490411 hasRelatedWork W4361951488 @default.
• W4362490411 isParatext "false" @default.
• W4362490411 isRetracted "false" @default.
• W4362490411 workType "article" @default.