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- W4362490908 abstract "<div>Abstract<p>Current therapeutic strategies against Wilms' tumor (WT) reach 80% to 85% success rate. In spite of this, a remaining 15% to 20% of tumors relapse and are associated with increased metastasis and poor prognosis. To identify new regulators of WT progression, we screened for developmental target genes of Pax2, a key regulator of kidney development and a WT signature gene. We show that one of these target genes, <i>calcineurin A–binding protein</i> (<i>CnABP</i>), is coexpressed with <i>Pax2</i> during kidney development and is overexpressed in >70% of WT samples analyzed. The <i>CnABP</i> gene encodes a novel protein product conserved in higher vertebrates. We show that CnABP promotes cell proliferation and migration in cell culture experiments. Biochemical analyses additionally identified an interaction between CnABP and calcineurin Aβ, the catalytic subunit of the calcium-responsive serine/threonine phosphatase calcineurin. We show that this interaction leads to the inhibition of calcineurin phosphatase activity and prevents nuclear factor of activated T-cell (NFAT) nuclear translocation. Inhibition of NFAT nuclear localization results in decreased NFAT transcriptional response. Together, these data identify a new modulator of calcineurin signaling up-regulated in WTs. (Mol Cancer Res 2009;7(6):821–31)</p></div>" @default.
- W4362490908 created "2023-04-05" @default.
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- W4362490908 date "2023-04-03" @default.
- W4362490908 modified "2023-10-17" @default.
- W4362490908 title "Data from Calcineurin A–Binding Protein, a Novel Modulator of the Calcineurin-Nuclear Factor of Activated T-Cell Signaling Pathway, Is Overexpressed in Wilms' Tumors and Promotes Cell Migration" @default.
- W4362490908 doi "https://doi.org/10.1158/1541-7786.c.6542143.v1" @default.
- W4362490908 hasPublicationYear "2023" @default.
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