FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362491831> ?p ?o ?g. }

• W4362491831 abstract "<div>Abstract<p>Activator protein-1 (AP-1) regulates the expression of several genes involved in human tumorigenesis. However, there is little known about this transcription factor in pancreatic ductal adenocarcinoma. We recently found high levels of AP-1-binding activities and multiple AP-1/DNA complexes containing c-Jun, JunD, Fra1, and Fra2 in pancreatic cancer cells. Transient transfection assays indicated that AP-1 was functional and capable of transactivating its gene targets. Furthermore, a c-Jun transactivation mutant inhibited anchorage-dependent and anchorage-independent proliferation, suggesting that AP-1 had an essential role in pancreatic cancer cells. Our study also uncovered a novel mechanism by which protein kinase Akt controls c-Jun activity in pancreatic cancer cells. Indeed, distinct from its known ability to induce <i>c-fos</i> and <i>fra1</i> and to stabilize c-Jun, Akt appeared to directly regulate the transcriptional activity of c-Jun independently of the phosphorylation sites targeted by c-Jun NH₂-terminal kinase (Ser⁶³/Ser⁷³) and glycogen synthase kinase-3 (Thr²³⁹). Our data also suggest that growth factors might use this Akt-regulated mechanism to potently induce c-Jun targets such as cyclin D1. Collectively, our findings indicate that AP-1 has an important function in pancreatic cancer cells and provide evidence for a previously unknown Akt-mediated mechanism of c-Jun activation. (Mol Cancer Res 2009;7(5):745–54)</p></div>" @default.
• W4362491831 created "2023-04-05" @default.
• W4362491831 creator A5028206626 @default.
• W4362491831 creator A5034667433 @default.
• W4362491831 creator A5043292469 @default.
• W4362491831 creator A5045419726 @default.
• W4362491831 creator A5051329035 @default.
• W4362491831 creator A5052428479 @default.
• W4362491831 creator A5062536269 @default.
• W4362491831 creator A5066866150 @default.
• W4362491831 creator A5068575891 @default.
• W4362491831 creator A5087376683 @default.
• W4362491831 date "2023-04-03" @default.
• W4362491831 modified "2023-10-16" @default.
• W4362491831 title "Data from Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism" @default.
• W4362491831 doi "https://doi.org/10.1158/1541-7786.c.6541996" @default.
• W4362491831 hasPublicationYear "2023" @default.
• W4362491831 type Work @default.
• W4362491831 citedByCount "0" @default.
• W4362491831 crossrefType "posted-content" @default.
• W4362491831 hasAuthorship W4362491831A5028206626 @default.
• W4362491831 hasAuthorship W4362491831A5034667433 @default.
• W4362491831 hasAuthorship W4362491831A5043292469 @default.
• W4362491831 hasAuthorship W4362491831A5045419726 @default.
• W4362491831 hasAuthorship W4362491831A5051329035 @default.
• W4362491831 hasAuthorship W4362491831A5052428479 @default.
• W4362491831 hasAuthorship W4362491831A5062536269 @default.
• W4362491831 hasAuthorship W4362491831A5066866150 @default.
• W4362491831 hasAuthorship W4362491831A5068575891 @default.
• W4362491831 hasAuthorship W4362491831A5087376683 @default.
• W4362491831 hasBestOaLocation W43624918312 @default.
• W4362491831 hasConcept C104317684 @default.
• W4362491831 hasConcept C11960822 @default.
• W4362491831 hasConcept C121608353 @default.
• W4362491831 hasConcept C1292079 @default.
• W4362491831 hasConcept C1491633281 @default.
• W4362491831 hasConcept C153911025 @default.
• W4362491831 hasConcept C184235292 @default.
• W4362491831 hasConcept C185592680 @default.
• W4362491831 hasConcept C199835354 @default.
• W4362491831 hasConcept C2780210213 @default.
• W4362491831 hasConcept C29537977 @default.
• W4362491831 hasConcept C502942594 @default.
• W4362491831 hasConcept C54009773 @default.
• W4362491831 hasConcept C54355233 @default.
• W4362491831 hasConcept C55493867 @default.
• W4362491831 hasConcept C555283112 @default.
• W4362491831 hasConcept C62478195 @default.
• W4362491831 hasConcept C75217442 @default.
• W4362491831 hasConcept C86339819 @default.
• W4362491831 hasConcept C86554907 @default.
• W4362491831 hasConcept C86803240 @default.
• W4362491831 hasConcept C88045685 @default.
• W4362491831 hasConcept C95444343 @default.
• W4362491831 hasConceptScore W4362491831C104317684 @default.
• W4362491831 hasConceptScore W4362491831C11960822 @default.
• W4362491831 hasConceptScore W4362491831C121608353 @default.
• W4362491831 hasConceptScore W4362491831C1292079 @default.
• W4362491831 hasConceptScore W4362491831C1491633281 @default.
• W4362491831 hasConceptScore W4362491831C153911025 @default.
• W4362491831 hasConceptScore W4362491831C184235292 @default.
• W4362491831 hasConceptScore W4362491831C185592680 @default.
• W4362491831 hasConceptScore W4362491831C199835354 @default.
• W4362491831 hasConceptScore W4362491831C2780210213 @default.
• W4362491831 hasConceptScore W4362491831C29537977 @default.
• W4362491831 hasConceptScore W4362491831C502942594 @default.
• W4362491831 hasConceptScore W4362491831C54009773 @default.
• W4362491831 hasConceptScore W4362491831C54355233 @default.
• W4362491831 hasConceptScore W4362491831C55493867 @default.
• W4362491831 hasConceptScore W4362491831C555283112 @default.
• W4362491831 hasConceptScore W4362491831C62478195 @default.
• W4362491831 hasConceptScore W4362491831C75217442 @default.
• W4362491831 hasConceptScore W4362491831C86339819 @default.
• W4362491831 hasConceptScore W4362491831C86554907 @default.
• W4362491831 hasConceptScore W4362491831C86803240 @default.
• W4362491831 hasConceptScore W4362491831C88045685 @default.
• W4362491831 hasConceptScore W4362491831C95444343 @default.
• W4362491831 hasLocation W43624918311 @default.
• W4362491831 hasLocation W43624918312 @default.
• W4362491831 hasOpenAccess W4362491831 @default.
• W4362491831 hasPrimaryLocation W43624918311 @default.
• W4362491831 hasRelatedWork W1964515703 @default.
• W4362491831 hasRelatedWork W1988747615 @default.
• W4362491831 hasRelatedWork W2026199302 @default.
• W4362491831 hasRelatedWork W2037154041 @default.
• W4362491831 hasRelatedWork W2038889862 @default.
• W4362491831 hasRelatedWork W2044529491 @default.
• W4362491831 hasRelatedWork W2065575443 @default.
• W4362491831 hasRelatedWork W2134679799 @default.
• W4362491831 hasRelatedWork W2725632415 @default.
• W4362491831 hasRelatedWork W2744183625 @default.
• W4362491831 isParatext "false" @default.
• W4362491831 isRetracted "false" @default.
• W4362491831 workType "article" @default.