FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362493045> ?p ?o ?g. }

• W4362493045 abstract "<div>Abstract<p>Leukemia inhibitory factor receptor (LIFR) and its ligand LIF play a critical role in cancer progression, metastasis, stem cell maintenance, and therapy resistance. Here, we describe a rationally designed first-in-class inhibitor of LIFR, EC359, which directly interacts with LIFR to effectively block LIF/LIFR interactions. EC359 treatment exhibits antiproliferative effects, reduces invasiveness and stemness, and promotes apoptosis in triple-negative breast cancer (TNBC) cell lines. The activity of EC359 is dependent on LIF and LIFR expression, and treatment with EC359 attenuated the activation of LIF/LIFR-driven pathways, including STAT3, mTOR, and AKT. Concomitantly, EC359 was also effective in blocking signaling by other LIFR ligands (CTF1, CNTF, and OSM) that interact at LIF/LIFR interface. EC359 significantly reduced tumor progression in TNBC xenografts and patient-derived xenografts (PDX), and reduced proliferation in patient-derived primary TNBC explants. EC359 exhibits distinct pharmacologic advantages, including oral bioavailability, and <i>in vivo</i> stability. Collectively, these data support EC359 as a novel targeted therapeutic that inhibits LIFR oncogenic signaling.</p><p><i>See related commentary by Shi et al., p. 1337</i></p></div>" @default.
• W4362493045 created "2023-04-05" @default.
• W4362493045 creator A5001874444 @default.
• W4362493045 creator A5007825968 @default.
• W4362493045 creator A5010406195 @default.
• W4362493045 creator A5012804596 @default.
• W4362493045 creator A5019505600 @default.
• W4362493045 creator A5036923059 @default.
• W4362493045 creator A5043867874 @default.
• W4362493045 creator A5044307373 @default.
• W4362493045 creator A5046757138 @default.
• W4362493045 creator A5049933687 @default.
• W4362493045 creator A5050207103 @default.
• W4362493045 creator A5052297870 @default.
• W4362493045 creator A5053069471 @default.
• W4362493045 creator A5054728664 @default.
• W4362493045 creator A5054763940 @default.
• W4362493045 creator A5060628869 @default.
• W4362493045 creator A5062374936 @default.
• W4362493045 creator A5064393266 @default.
• W4362493045 creator A5072990107 @default.
• W4362493045 creator A5077133681 @default.
• W4362493045 creator A5079455118 @default.
• W4362493045 creator A5081244737 @default.
• W4362493045 creator A5083922162 @default.
• W4362493045 creator A5086825763 @default.
• W4362493045 creator A5090010000 @default.
• W4362493045 creator A5091432775 @default.
• W4362493045 date "2023-04-03" @default.
• W4362493045 modified "2023-10-16" @default.
• W4362493045 title "Data from EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer" @default.
• W4362493045 doi "https://doi.org/10.1158/1535-7163.c.6538359.v1" @default.
• W4362493045 hasPublicationYear "2023" @default.
• W4362493045 type Work @default.
• W4362493045 citedByCount "0" @default.
• W4362493045 crossrefType "posted-content" @default.
• W4362493045 hasAuthorship W4362493045A5001874444 @default.
• W4362493045 hasAuthorship W4362493045A5007825968 @default.
• W4362493045 hasAuthorship W4362493045A5010406195 @default.
• W4362493045 hasAuthorship W4362493045A5012804596 @default.
• W4362493045 hasAuthorship W4362493045A5019505600 @default.
• W4362493045 hasAuthorship W4362493045A5036923059 @default.
• W4362493045 hasAuthorship W4362493045A5043867874 @default.
• W4362493045 hasAuthorship W4362493045A5044307373 @default.
• W4362493045 hasAuthorship W4362493045A5046757138 @default.
• W4362493045 hasAuthorship W4362493045A5049933687 @default.
• W4362493045 hasAuthorship W4362493045A5050207103 @default.
• W4362493045 hasAuthorship W4362493045A5052297870 @default.
• W4362493045 hasAuthorship W4362493045A5053069471 @default.
• W4362493045 hasAuthorship W4362493045A5054728664 @default.
• W4362493045 hasAuthorship W4362493045A5054763940 @default.
• W4362493045 hasAuthorship W4362493045A5060628869 @default.
• W4362493045 hasAuthorship W4362493045A5062374936 @default.
• W4362493045 hasAuthorship W4362493045A5064393266 @default.
• W4362493045 hasAuthorship W4362493045A5072990107 @default.
• W4362493045 hasAuthorship W4362493045A5077133681 @default.
• W4362493045 hasAuthorship W4362493045A5079455118 @default.
• W4362493045 hasAuthorship W4362493045A5081244737 @default.
• W4362493045 hasAuthorship W4362493045A5083922162 @default.
• W4362493045 hasAuthorship W4362493045A5086825763 @default.
• W4362493045 hasAuthorship W4362493045A5090010000 @default.
• W4362493045 hasAuthorship W4362493045A5091432775 @default.
• W4362493045 hasConcept C106825092 @default.
• W4362493045 hasConcept C11988809 @default.
• W4362493045 hasConcept C121608353 @default.
• W4362493045 hasConcept C126322002 @default.
• W4362493045 hasConcept C185592680 @default.
• W4362493045 hasConcept C203014093 @default.
• W4362493045 hasConcept C27284151 @default.
• W4362493045 hasConcept C2778690821 @default.
• W4362493045 hasConcept C2778923194 @default.
• W4362493045 hasConcept C2779013556 @default.
• W4362493045 hasConcept C2780110267 @default.
• W4362493045 hasConcept C502942594 @default.
• W4362493045 hasConcept C530470458 @default.
• W4362493045 hasConcept C62478195 @default.
• W4362493045 hasConcept C71924100 @default.
• W4362493045 hasConcept C75217442 @default.
• W4362493045 hasConcept C86554907 @default.
• W4362493045 hasConcept C86803240 @default.
• W4362493045 hasConcept C95444343 @default.
• W4362493045 hasConceptScore W4362493045C106825092 @default.
• W4362493045 hasConceptScore W4362493045C11988809 @default.
• W4362493045 hasConceptScore W4362493045C121608353 @default.
• W4362493045 hasConceptScore W4362493045C126322002 @default.
• W4362493045 hasConceptScore W4362493045C185592680 @default.
• W4362493045 hasConceptScore W4362493045C203014093 @default.
• W4362493045 hasConceptScore W4362493045C27284151 @default.
• W4362493045 hasConceptScore W4362493045C2778690821 @default.
• W4362493045 hasConceptScore W4362493045C2778923194 @default.
• W4362493045 hasConceptScore W4362493045C2779013556 @default.
• W4362493045 hasConceptScore W4362493045C2780110267 @default.
• W4362493045 hasConceptScore W4362493045C502942594 @default.
• W4362493045 hasConceptScore W4362493045C530470458 @default.
• W4362493045 hasConceptScore W4362493045C62478195 @default.
• W4362493045 hasConceptScore W4362493045C71924100 @default.
• W4362493045 hasConceptScore W4362493045C75217442 @default.
• W4362493045 hasConceptScore W4362493045C86554907 @default.
• W4362493045 hasConceptScore W4362493045C86803240 @default.
• W4362493045 hasConceptScore W4362493045C95444343 @default.

• next