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- W4362497329 abstract "Abstract Previous studies have suggested that the genomic Gag/Gag-Pol complex is involved in recruiting the LysRS/tRNA complex, and that the selective packaging of the tRNA primer requires HIV-1 Gag and Gag-Pol. Furthermore, in vitro experiments have demonstrated an interaction between LysRS and Gag, and HIV-1 initiates the process of reverse transcription by using LysRS to bind to the genomic RNA at the primer binding site. These findings strongly suggest that the gag protein plays a critical role in matching the primer binding site. In this study, the author investigated the amino acid sequences of Gag proteins of several retroviruses and their matching primer binding sites. The analysis showed that the amino acid sequence ARG of Gag proteins of HTLV-1, HTLV-2, STLV-1, and STLV-2 match their primer binding site GGGGGCTCG in the 3'-to-5' direction, while the amino acid sequence SPR of Gag proteins of HIV-1, HIV-2, SIV, and FIV match their primer binding site GGCGCCCGA in the 3'-to-5' direction. These findings suggest a potential mechanism for the specificity of reverse transcription in retroviruses. However, it is important to note that the primer binding sites of different viruses are extremely stable, and other amino acid sequences of Gag proteins may also match these sites. Further research is needed to confirm this hypothesis. Overall, the study provides valuable insights into the mechanisms of retroviral reverse transcription, and provides an advance for further research in this area." @default.
- W4362497329 created "2023-04-05" @default.
- W4362497329 creator A5075302417 @default.
- W4362497329 date "2023-04-03" @default.
- W4362497329 modified "2023-09-27" @default.
- W4362497329 title "Deciphering the Match Patterns between Gag Protein and Primer Binding Site based on Bioinformatics Analysis" @default.
- W4362497329 doi "https://doi.org/10.21203/rs.3.rs-2738423/v1" @default.
- W4362497329 hasPublicationYear "2023" @default.
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