Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362505770> ?p ?o ?g. }
- W4362505770 endingPage "984" @default.
- W4362505770 startingPage "967" @default.
- W4362505770 abstract "The potassium chloride cotransporter 2 (KCC2) is the main Cl− extruder in neurons. Any alteration in KCC2 levels leads to changes in Cl− homeostasis and, consequently, in the polarity and amplitude of inhibitory synaptic potentials mediated by GABA or glycine. Axotomy downregulates KCC2 in many different motoneurons and it is suspected that interruption of muscle-derived factors maintaining motoneuron KCC2 expression is in part responsible. In here, we demonstrate that KCC2 is expressed in all oculomotor nuclei of cat and rat, but while trochlear and oculomotor motoneurons downregulate KCC2 after axotomy, expression is unaltered in abducens motoneurons. Exogenous application of vascular endothelial growth factor (VEGF), a neurotrophic factor expressed in muscle, upregulated KCC2 in axotomized abducens motoneurons above control levels. In parallel, a physiological study using cats chronically implanted with electrodes for recording abducens motoneurons in awake animals, demonstrated that inhibitory inputs related to off-fixations and off-directed saccades in VEGF-treated axotomized abducens motoneurons were significantly higher than in control, but eye-related excitatory signals in the on direction were unchanged. This is the first report of lack of KCC2 regulation in a motoneuron type after injury, proposing a role for VEGF in KCC2 regulation and demonstrating the link between KCC2 and synaptic inhibition in awake, behaving animals." @default.
- W4362505770 created "2023-04-05" @default.
- W4362505770 creator A5003096476 @default.
- W4362505770 creator A5011496732 @default.
- W4362505770 creator A5029258084 @default.
- W4362505770 creator A5090546937 @default.
- W4362505770 date "2023-04-01" @default.
- W4362505770 modified "2023-10-16" @default.
- W4362505770 title "Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF" @default.
- W4362505770 cites W1561821342 @default.
- W4362505770 cites W1588629441 @default.
- W4362505770 cites W1894493322 @default.
- W4362505770 cites W1966537571 @default.
- W4362505770 cites W1972058394 @default.
- W4362505770 cites W1974940638 @default.
- W4362505770 cites W1975698062 @default.
- W4362505770 cites W1978052983 @default.
- W4362505770 cites W1978979403 @default.
- W4362505770 cites W1985922155 @default.
- W4362505770 cites W1987823791 @default.
- W4362505770 cites W1991545156 @default.
- W4362505770 cites W1995137108 @default.
- W4362505770 cites W1995797290 @default.
- W4362505770 cites W1996493388 @default.
- W4362505770 cites W1999520388 @default.
- W4362505770 cites W2004284432 @default.
- W4362505770 cites W2016987831 @default.
- W4362505770 cites W2017791457 @default.
- W4362505770 cites W2019909157 @default.
- W4362505770 cites W2028347879 @default.
- W4362505770 cites W2039479200 @default.
- W4362505770 cites W2045643520 @default.
- W4362505770 cites W2048373958 @default.
- W4362505770 cites W2052792709 @default.
- W4362505770 cites W2054234898 @default.
- W4362505770 cites W2059803012 @default.
- W4362505770 cites W2060072391 @default.
- W4362505770 cites W2064640860 @default.
- W4362505770 cites W2064983289 @default.
- W4362505770 cites W2069669555 @default.
- W4362505770 cites W2072125344 @default.
- W4362505770 cites W2072648819 @default.
- W4362505770 cites W2079747710 @default.
- W4362505770 cites W2088607178 @default.
- W4362505770 cites W2090305787 @default.
- W4362505770 cites W2095230102 @default.
- W4362505770 cites W2098781914 @default.
- W4362505770 cites W2126454332 @default.
- W4362505770 cites W2128676313 @default.
- W4362505770 cites W2129455633 @default.
- W4362505770 cites W2135829698 @default.
- W4362505770 cites W2143906670 @default.
- W4362505770 cites W2145861425 @default.
- W4362505770 cites W2152008565 @default.
- W4362505770 cites W2156074109 @default.
- W4362505770 cites W2167049113 @default.
- W4362505770 cites W2170081922 @default.
- W4362505770 cites W2171661590 @default.
- W4362505770 cites W2315170054 @default.
- W4362505770 cites W2510158334 @default.
- W4362505770 cites W2557832306 @default.
- W4362505770 cites W2571033529 @default.
- W4362505770 cites W2765348002 @default.
- W4362505770 cites W2793935026 @default.
- W4362505770 cites W2890803446 @default.
- W4362505770 cites W2916832766 @default.
- W4362505770 cites W2935255865 @default.
- W4362505770 cites W2937457820 @default.
- W4362505770 cites W2952837230 @default.
- W4362505770 cites W2973491579 @default.
- W4362505770 cites W2991471183 @default.
- W4362505770 cites W3006202913 @default.
- W4362505770 cites W3011635780 @default.
- W4362505770 cites W3016543547 @default.
- W4362505770 cites W3021414221 @default.
- W4362505770 cites W3093151643 @default.
- W4362505770 cites W3119388798 @default.
- W4362505770 cites W3127299485 @default.
- W4362505770 doi "https://doi.org/10.1007/s00429-023-02635-w" @default.
- W4362505770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37005931" @default.
- W4362505770 hasPublicationYear "2023" @default.
- W4362505770 type Work @default.
- W4362505770 citedByCount "0" @default.
- W4362505770 crossrefType "journal-article" @default.
- W4362505770 hasAuthorship W4362505770A5003096476 @default.
- W4362505770 hasAuthorship W4362505770A5011496732 @default.
- W4362505770 hasAuthorship W4362505770A5029258084 @default.
- W4362505770 hasAuthorship W4362505770A5090546937 @default.
- W4362505770 hasBestOaLocation W43625057702 @default.
- W4362505770 hasConcept C104317684 @default.
- W4362505770 hasConcept C112592302 @default.
- W4362505770 hasConcept C126322002 @default.
- W4362505770 hasConcept C127561419 @default.
- W4362505770 hasConcept C142724271 @default.
- W4362505770 hasConcept C160539049 @default.
- W4362505770 hasConcept C169760540 @default.
- W4362505770 hasConcept C170493617 @default.
- W4362505770 hasConcept C17077164 @default.