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- W4362506014 endingPage "400" @default.
- W4362506014 startingPage "387" @default.
- W4362506014 abstract "Chronic kidney disease-associated pruritus (CKD-aP) is often experienced by patients with CKD receiving dialysis. Approximately 40% of hemodialysis patients are 'moderately' to 'extremely bothered' by itching, associated with reduced quality of life, poor sleep quality, and depression as well as worse clinical outcomes, including increased medication use, infections, hospitalizations, and mortality.This review covers the pathophysiology and treatment landscape of CKD-aP, and the development, clinical efficacy, and safety profile of difelikefalin. We summarize the existing evidence, and discuss both the position of difelikefalin in the treatment pathway and potential future developments.Difelikefalin is a kappa opioid receptor agonist, with a primary mode of action that is outside of the central nervous system and provides an improved safety profile compared with other opioid agonists, with limited potential for abuse and dependency. Difelikefalin has demonstrated efficacy, tolerability, and safety profile in several large-scale clinical trials in more than 1,400 hemodialysis patients with CKD-aP treated for up to 64 weeks. Difelikefalin is the only approved treatment for CKD-aP in the U.S.A and Europe; other treatments are used off-label, have limited proof of efficacy in large-scale clinical trials in this patient population, and may present an increased risk of toxicity in patients with CKD." @default.
- W4362506014 created "2023-04-05" @default.
- W4362506014 creator A5001846180 @default.
- W4362506014 creator A5016502106 @default.
- W4362506014 creator A5064512017 @default.
- W4362506014 date "2023-04-13" @default.
- W4362506014 modified "2023-10-01" @default.
- W4362506014 title "Difelikefalin for the treatment of moderate-to-severe pruritus associated with chronic kidney disease on hemodialysis" @default.
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- W4362506014 doi "https://doi.org/10.1080/17512433.2023.2197209" @default.
- W4362506014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37010031" @default.