Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362507033> ?p ?o ?g. }
- W4362507033 abstract "Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring. Here, we provide functional data to support the notion that the SA subunit is not a mere passenger in this structure, but instead plays a key role in the localization of cohesin to diverse biological processes and promotes loading of the complex at these sites. We show that in cells acutely depleted for RAD21, SA proteins remain bound to chromatin, cluster in 3D and interact with CTCF, as well as with a wide range of RNA binding proteins involved in multiple RNA processing mechanisms. Accordingly, SA proteins interact with RNA, and R-loops, even in the absence of cohesin. Our results place SA1 on chromatin upstream of the cohesin ring and reveal a role for SA1 in cohesin loading which is independent of NIPBL, the canonical cohesin loader. We propose that SA1 takes advantage of structural R-loop platforms to link cohesin loading and chromatin structure with diverse functions. Since SA proteins are pan-cancer targets, and R-loops play an increasingly prevalent role in cancer biology, our results have important implications for the mechanistic understanding of SA proteins in cancer and disease." @default.
- W4362507033 created "2023-04-05" @default.
- W4362507033 creator A5013604041 @default.
- W4362507033 creator A5013997101 @default.
- W4362507033 creator A5017493082 @default.
- W4362507033 creator A5018729100 @default.
- W4362507033 creator A5019448436 @default.
- W4362507033 creator A5019457071 @default.
- W4362507033 creator A5020430668 @default.
- W4362507033 creator A5045738356 @default.
- W4362507033 creator A5064842058 @default.
- W4362507033 creator A5068833158 @default.
- W4362507033 creator A5071901071 @default.
- W4362507033 creator A5073537179 @default.
- W4362507033 creator A5084494815 @default.
- W4362507033 date "2023-04-03" @default.
- W4362507033 modified "2023-10-09" @default.
- W4362507033 title "Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading" @default.
- W4362507033 cites W1728543386 @default.
- W4362507033 cites W1964963969 @default.
- W4362507033 cites W1969103349 @default.
- W4362507033 cites W1972011626 @default.
- W4362507033 cites W1972307085 @default.
- W4362507033 cites W1973736002 @default.
- W4362507033 cites W1973752471 @default.
- W4362507033 cites W1975004069 @default.
- W4362507033 cites W1977752183 @default.
- W4362507033 cites W1989391941 @default.
- W4362507033 cites W1989540449 @default.
- W4362507033 cites W1992858116 @default.
- W4362507033 cites W2002954217 @default.
- W4362507033 cites W2003673194 @default.
- W4362507033 cites W2028022357 @default.
- W4362507033 cites W2045273474 @default.
- W4362507033 cites W2047005748 @default.
- W4362507033 cites W2066521860 @default.
- W4362507033 cites W2077952392 @default.
- W4362507033 cites W2080479776 @default.
- W4362507033 cites W2080752012 @default.
- W4362507033 cites W2084288806 @default.
- W4362507033 cites W2087587381 @default.
- W4362507033 cites W2088891952 @default.
- W4362507033 cites W2098549100 @default.
- W4362507033 cites W2107455041 @default.
- W4362507033 cites W2112479912 @default.
- W4362507033 cites W2114165700 @default.
- W4362507033 cites W2117028719 @default.
- W4362507033 cites W2119765524 @default.
- W4362507033 cites W2132089243 @default.
- W4362507033 cites W2133954951 @default.
- W4362507033 cites W2136603536 @default.
- W4362507033 cites W2139480055 @default.
- W4362507033 cites W2161413862 @default.
- W4362507033 cites W2163605769 @default.
- W4362507033 cites W2259938310 @default.
- W4362507033 cites W2310030657 @default.
- W4362507033 cites W2340421620 @default.
- W4362507033 cites W2345850272 @default.
- W4362507033 cites W2426320252 @default.
- W4362507033 cites W2511051356 @default.
- W4362507033 cites W2532485011 @default.
- W4362507033 cites W2626627929 @default.
- W4362507033 cites W2761461280 @default.
- W4362507033 cites W2768736041 @default.
- W4362507033 cites W2775505403 @default.
- W4362507033 cites W2781021886 @default.
- W4362507033 cites W2783028951 @default.
- W4362507033 cites W2795610153 @default.
- W4362507033 cites W2796109902 @default.
- W4362507033 cites W2800358055 @default.
- W4362507033 cites W2885656579 @default.
- W4362507033 cites W2886727482 @default.
- W4362507033 cites W2912269007 @default.
- W4362507033 cites W2913346540 @default.
- W4362507033 cites W2942370373 @default.
- W4362507033 cites W2949389238 @default.
- W4362507033 cites W2950710336 @default.
- W4362507033 cites W2952759709 @default.
- W4362507033 cites W2954613863 @default.
- W4362507033 cites W2979531443 @default.
- W4362507033 cites W2982290041 @default.
- W4362507033 cites W2998399076 @default.
- W4362507033 cites W3007279945 @default.
- W4362507033 cites W3023617318 @default.
- W4362507033 cites W3025316148 @default.
- W4362507033 cites W3034206148 @default.
- W4362507033 cites W3046933533 @default.
- W4362507033 cites W3127356623 @default.
- W4362507033 cites W3132777875 @default.
- W4362507033 cites W4362507033 @default.
- W4362507033 doi "https://doi.org/10.7554/elife.79386" @default.
- W4362507033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37010886" @default.
- W4362507033 hasPublicationYear "2023" @default.
- W4362507033 type Work @default.
- W4362507033 citedByCount "4" @default.
- W4362507033 countsByYear W43625070332023 @default.
- W4362507033 crossrefType "journal-article" @default.
- W4362507033 hasAuthorship W4362507033A5013604041 @default.
- W4362507033 hasAuthorship W4362507033A5013997101 @default.
- W4362507033 hasAuthorship W4362507033A5017493082 @default.