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• W4362507375 abstract "Fold-change detection is widespread in sensory systems of various organisms. Dynamic DNA nanotechnology provides an important toolbox for reproducing structures and responses of cellular circuits. In this work, we construct an enzyme-free nucleic acid circuit based on the incoherent feed-forward loop using toehold-mediated DNA strand displacement reactions and explore its dynamic behaviors. The mathematical model based on ordinary differential equations is used to evaluate the parameter regime required for fold-change detection. After selecting appropriate parameters, the constructed synthetic circuit exhibits approximate fold-change detection for multiple rounds of inputs with different initial concentrations. This work is anticipated to shed new light on the design of DNA dynamic circuits in the enzyme-free environment." @default.
• W4362507375 created "2023-04-05" @default.
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• W4362507375 date "2023-04-13" @default.
• W4362507375 modified "2023-10-17" @default.
• W4362507375 title "Enzyme‐Free Nucleic Acid Circuits for Fold‐Change Detection" @default.
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• W4362507375 doi "https://doi.org/10.1002/cplu.202300083" @default.
• W4362507375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37005227" @default.
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