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• W4362518771 abstract "Psychotic disorders have consistently been associated with inflammatory changes, including alterations in the number of immune cells in the peripheral blood. However, there have been no comprehensive meta-analysis, which have evaluated the amount of circulating immune cells from both the myeloid and lymphoid line including specialized subsets in blood and cerebrospinal fluid (CSF) of patients with psychotic disorders compared to healthy controls. The aim of this study was therefore to systematically evaluate the circulating immune cells including subsets in blood and CSF from patients with psychotic disorders compared to healthy controls. Multiple databases (PubMed, EMBASE, Cochrane Library, Web of Science, ClinicalTrials.gov and PsycINFO) were searched for eligible studies up until the 18th of October 2022. All studies investigating circulating immune cells in blood and CSF from patients with psychotic disorders (ICD-10: F20 and F22-29) compared to healthy controls were included. One author screened titles and abstracts, and 2 independent reviewers examined full-text reports. Studies that did not include healthy control individuals or included control individuals with recent hospital contacts or admissions that might affect immune cell functioning were excluded. A total of 16,585 articles were identified, after the removal of duplicates and screening by title and abstract, 465 studies were included for full text inspection. Data-extraction is still ongoing and thus the final results of the meta-analysis are not yet available, but preliminary results will be presented from the number of articles where data-extraction have been completed. The preliminary review of the articles has pointed towards a lack of articles that examines potential differences in the number of immune cells including subsets in the CSF of patients with psychotic disorders compared to healthy controls. The CSF is a medium of particular interest because of its closer proximity to the brain compared to peripheral blood. Furthermore, there is a need for more studies with results that are controlled for obesity and smoking, which are both seen more frequently in psychotic patients, and both influence inflammatory parameters." @default.
• W4362518771 created "2023-04-06" @default.
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• W4362518771 date "2023-04-01" @default.
• W4362518771 modified "2023-09-30" @default.
• W4362518771 title "Immune Cell Alterations in Patients with Psychosis: A Comprehensive Systematic Review and Meta-analysis" @default.
• W4362518771 doi "https://doi.org/10.1016/j.jadr.2023.100529" @default.
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