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• W4362518793 abstract "Leukocytes recruited into the central nervous system after infection help clear pathogens and provide long-lasting immune surveillance, but also can contribute to harmful post-infectious neuroinflammation. Listeria monocytogenes (Lm) is a neuroinvasive bacterial pathogen of humans and a commonly used model organism for studying immune responses to infection. Post-infectious cognitive decline in Lm infected mice has not been demonstrated. We hypothesized that neuroinvasive Lm infection would trigger cognitive decline in accord with persistence of increased numbers of recruited leukocytes in the brain. Male C57BL/6J mice (age 8 wks) were injected intraperitoneally with neuroinvasive Lm strain 10403s, avirulent non-neuroinvasive Δhly mutants, or sterile saline. All mice received antibiotics 2-16d post-injection (p.i.) and underwent cognitive testing 1 month (mo) or 4 mo p.i. using the Ethovision PhenoTyper with Cognition Wall (Noldus), a food reward-based discrimination procedure using automated home cage based observation and data analysis with continuous monitoring. Brain leukocytes were analyzed flow cytometry. Mice infected with neuroinvasive Lm 10403s, but not Δhly Lm, had significantly worse cognitive outcomes than did uninfected mice 4 mo p.i. but not 1 mo p.i. Changes included decreased movement, delayed success in criterion achievement, and impaired extinguishing of prior learning. Numbers of CD8+ and CD4+ T-lymphocytes, and subpopulations expressing CD69 and tissue resident memory (TRM) cells were significantly increased 1 mo after infection with Lm 10403s, but not Δhly Lm. By 4 mo p.i., CD8+, CD69+CD8+T-lymphocytes and CD8+ TRM remained significantly elevated, but CD4+ cells were not different from uninfected mice. Greater numbers of CD8+ cells, particularly CD8+ TRM, and lower CD4/CD8 ratio correlated significantly with reduced movement and increased time to criterion success. Cognitive impairment follows recovery from neuroinvasive Lm infection but not by Lm Δhly mutants that do not induce brain inflammation. Identification of dynamic shifts in brain CD8+ and CD4+ T-lymphocyte populations coupled with cognitive assessments suggest CD8+ cells, e.g. CD8+ TRM, promote neuroinflammation and injury whereas CD4+ cells may have regulatory activity. Cognitive decline manifests as initial influxes of CD4+ cells regress towards homeostatic levels while numbers of CD8+ cells remain significantly elevated." @default.
• W4362518793 created "2023-04-06" @default.
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• W4362518793 date "2023-04-01" @default.
• W4362518793 modified "2023-09-30" @default.
• W4362518793 title "Systemic infection of mice with neuroinvasive Listeria monocytogenes triggers cognitive decline and persistent increases in brain CD8+ T-lymphocyte populations" @default.
• W4362518793 doi "https://doi.org/10.1016/j.jadr.2023.100536" @default.
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