FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362520565> ?p ?o ?g. }

• W4362520565 abstract "Myoregulin (MLN) is a member of the regulin family, a group of homologous membrane proteins that bind to and regulate the activity of the sarcoplasmic reticulum Ca2+-ATPase (SERCA). MLN, which is expressed in skeletal muscle, contains an acidic residue in its transmembrane domain. The location of this residue, Asp35, is unusual because the relative occurrence of aspartate is very rare (<0.2%) within the transmembrane helix regions. Therefore, we used atomistic simulations and ATPase activity assays of protein co-reconstitutions to probe the functional role of MLN residue Asp35. These structural and functional studies showed Asp35 has no effects on SERCA's affinity for Ca2+ or the structural integrity of MLN in the lipid bilayer. Instead, Asp35 controls SERCA inhibition by populating a bound-like orientation of MLN. We propose Asp35 provides a functional advantage over other members of the regulin family by populating preexisting MLN conformations required for MLN-specific regulation of SERCA. Overall, this study provides new clues about the evolution and functional divergence of the regulin family and offers novel insights into the functional role of acidic residues in transmembrane protein domains." @default.
• W4362520565 created "2023-04-06" @default.
• W4362520565 creator A5022808199 @default.
• W4362520565 creator A5049403758 @default.
• W4362520565 creator A5064668180 @default.
• W4362520565 creator A5066036393 @default.
• W4362520565 creator A5076327164 @default.
• W4362520565 date "2023-04-04" @default.
• W4362520565 modified "2023-09-26" @default.
• W4362520565 title "Functional Role of an Unusual Transmembrane Acidic Residue in the Calcium Pump Regulator Myoregulin" @default.
• W4362520565 cites W1987421070 @default.
• W4362520565 cites W2015736466 @default.
• W4362520565 cites W2024313472 @default.
• W4362520565 cites W2026169488 @default.
• W4362520565 cites W2046771956 @default.
• W4362520565 cites W2053116433 @default.
• W4362520565 cites W2071160031 @default.
• W4362520565 cites W2104534420 @default.
• W4362520565 cites W2145537234 @default.
• W4362520565 cites W2148789926 @default.
• W4362520565 cites W2237493771 @default.
• W4362520565 cites W2261810053 @default.
• W4362520565 cites W2313116527 @default.
• W4362520565 cites W2531568775 @default.
• W4362520565 cites W2559801043 @default.
• W4362520565 cites W2737546073 @default.
• W4362520565 cites W2766617043 @default.
• W4362520565 cites W2809198214 @default.
• W4362520565 cites W2969452500 @default.
• W4362520565 cites W2969466971 @default.
• W4362520565 cites W2989052455 @default.
• W4362520565 cites W3043539949 @default.
• W4362520565 cites W3195293507 @default.
• W4362520565 cites W4289523599 @default.
• W4362520565 doi "https://doi.org/10.1021/acs.biochem.3c00026" @default.
• W4362520565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37014032" @default.
• W4362520565 hasPublicationYear "2023" @default.
• W4362520565 type Work @default.
• W4362520565 citedByCount "0" @default.
• W4362520565 crossrefType "journal-article" @default.
• W4362520565 hasAuthorship W4362520565A5022808199 @default.
• W4362520565 hasAuthorship W4362520565A5049403758 @default.
• W4362520565 hasAuthorship W4362520565A5064668180 @default.
• W4362520565 hasAuthorship W4362520565A5066036393 @default.
• W4362520565 hasAuthorship W4362520565A5076327164 @default.
• W4362520565 hasConcept C103077935 @default.
• W4362520565 hasConcept C104317684 @default.
• W4362520565 hasConcept C118892022 @default.
• W4362520565 hasConcept C12554922 @default.
• W4362520565 hasConcept C150194340 @default.
• W4362520565 hasConcept C158617107 @default.
• W4362520565 hasConcept C170493617 @default.
• W4362520565 hasConcept C181199279 @default.
• W4362520565 hasConcept C185592680 @default.
• W4362520565 hasConcept C23265538 @default.
• W4362520565 hasConcept C24530287 @default.
• W4362520565 hasConcept C2781338088 @default.
• W4362520565 hasConcept C2781414619 @default.
• W4362520565 hasConcept C39944091 @default.
• W4362520565 hasConcept C41625074 @default.
• W4362520565 hasConcept C55493867 @default.
• W4362520565 hasConcept C5911399 @default.
• W4362520565 hasConcept C86803240 @default.
• W4362520565 hasConcept C95444343 @default.
• W4362520565 hasConceptScore W4362520565C103077935 @default.
• W4362520565 hasConceptScore W4362520565C104317684 @default.
• W4362520565 hasConceptScore W4362520565C118892022 @default.
• W4362520565 hasConceptScore W4362520565C12554922 @default.
• W4362520565 hasConceptScore W4362520565C150194340 @default.
• W4362520565 hasConceptScore W4362520565C158617107 @default.
• W4362520565 hasConceptScore W4362520565C170493617 @default.
• W4362520565 hasConceptScore W4362520565C181199279 @default.
• W4362520565 hasConceptScore W4362520565C185592680 @default.
• W4362520565 hasConceptScore W4362520565C23265538 @default.
• W4362520565 hasConceptScore W4362520565C24530287 @default.
• W4362520565 hasConceptScore W4362520565C2781338088 @default.
• W4362520565 hasConceptScore W4362520565C2781414619 @default.
• W4362520565 hasConceptScore W4362520565C39944091 @default.
• W4362520565 hasConceptScore W4362520565C41625074 @default.
• W4362520565 hasConceptScore W4362520565C55493867 @default.
• W4362520565 hasConceptScore W4362520565C5911399 @default.
• W4362520565 hasConceptScore W4362520565C86803240 @default.
• W4362520565 hasConceptScore W4362520565C95444343 @default.
• W4362520565 hasFunder F4320334506 @default.
• W4362520565 hasFunder F4320337354 @default.
• W4362520565 hasLocation W43625205651 @default.
• W4362520565 hasLocation W43625205652 @default.
• W4362520565 hasOpenAccess W4362520565 @default.
• W4362520565 hasPrimaryLocation W43625205651 @default.
• W4362520565 hasRelatedWork W1588036636 @default.
• W4362520565 hasRelatedWork W1680293479 @default.
• W4362520565 hasRelatedWork W1989575369 @default.
• W4362520565 hasRelatedWork W2025369070 @default.
• W4362520565 hasRelatedWork W2067680247 @default.
• W4362520565 hasRelatedWork W2164276955 @default.
• W4362520565 hasRelatedWork W2165716854 @default.
• W4362520565 hasRelatedWork W2331287288 @default.
• W4362520565 hasRelatedWork W2941951858 @default.
• W4362520565 hasRelatedWork W4362520565 @default.
• W4362520565 isParatext "false" @default.

• next