Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362520912> ?p ?o ?g. }
- W4362520912 endingPage "2633" @default.
- W4362520912 startingPage "2624" @default.
- W4362520912 abstract "Griseofulvin (GSF) is one of the most widely used antifungal suffering from low water solubility and limited bioavailability. Here, cyclodextrin (CD) derivatives of hydroxypropyl-beta-CD (HPβCD) known for its high-water solubility were used to form inclusion complexes (ICs) with GSF. Here, the molecular modeling study revealed the more efficient complex formation with 1:2 (guest:CD) stoichiometry, so ICs of GSF-HPβCD were prepared using a 1:2 molar ratio (GSF:HPβCD) and then mixed with pullulan (PULL) to generate nanofibers (NFs) using the electrospinning technique. PULL is a nontoxic water-soluble biopolymer and the ultimate PULL/GSF-HPβCD-IC NF was obtained with a defect-free fiber morphology having 805 ± 180 nm average diameter. The self-standing and flexible PULL/GSF-HPβCD-IC NF was achieved to be produced with a loading efficiency of ∼98% corresponding to ∼6.4% (w/w) of drug content. In comparison, the control sample of PULL/GSF NF was formed with a lower loading efficiency value of ∼72% which equals to ∼4.7% (w/w) of GSF content. Additionally, PULL/GSF-HPβCD-IC NF provided an enhanced aqueous solubility for GSF compared to PULL/GSF NF so a faster release profile with ∼2.5 times higher released amount was obtained due to inclusion complexation between GSF and HPβCD within the nanofibrous web. On the other hand, both nanofibrous webs rapidly disintegrated (∼2 s) in the artificial saliva medium that mimics the oral cavity environment. Briefly, PULL/GSF-HPβCD-IC NF can be a promising dosage formulation as a fast-disintegrating delivery system for antifungal oral administration owing to the improved physicochemical properties of GSF." @default.
- W4362520912 created "2023-04-06" @default.
- W4362520912 creator A5014575520 @default.
- W4362520912 creator A5086136904 @default.
- W4362520912 creator A5087768682 @default.
- W4362520912 creator A5089190548 @default.
- W4362520912 creator A5089312926 @default.
- W4362520912 date "2023-04-04" @default.
- W4362520912 modified "2023-10-01" @default.
- W4362520912 title "Fast-Disintegrating Nanofibrous Web of Pullulan/Griseofulvin–Cyclodextrin Inclusion Complexes" @default.
- W4362520912 cites W2001752809 @default.
- W4362520912 cites W2007395042 @default.
- W4362520912 cites W2021409079 @default.
- W4362520912 cites W2031281559 @default.
- W4362520912 cites W2044591029 @default.
- W4362520912 cites W2054800049 @default.
- W4362520912 cites W2059674127 @default.
- W4362520912 cites W2062445636 @default.
- W4362520912 cites W2062693459 @default.
- W4362520912 cites W2067763594 @default.
- W4362520912 cites W2075242633 @default.
- W4362520912 cites W2149635132 @default.
- W4362520912 cites W2465696082 @default.
- W4362520912 cites W2508320477 @default.
- W4362520912 cites W2736919105 @default.
- W4362520912 cites W2767842869 @default.
- W4362520912 cites W2911358073 @default.
- W4362520912 cites W2915001950 @default.
- W4362520912 cites W2929722587 @default.
- W4362520912 cites W2954497327 @default.
- W4362520912 cites W2968867377 @default.
- W4362520912 cites W2969830238 @default.
- W4362520912 cites W2987664667 @default.
- W4362520912 cites W3005118034 @default.
- W4362520912 cites W3008497543 @default.
- W4362520912 cites W3034861237 @default.
- W4362520912 cites W3043993900 @default.
- W4362520912 cites W3060458859 @default.
- W4362520912 cites W3088408620 @default.
- W4362520912 cites W3096021701 @default.
- W4362520912 cites W3101544822 @default.
- W4362520912 cites W3112986279 @default.
- W4362520912 cites W3141186455 @default.
- W4362520912 cites W3162548879 @default.
- W4362520912 cites W3165793560 @default.
- W4362520912 cites W3168107479 @default.
- W4362520912 cites W3173923126 @default.
- W4362520912 cites W3184425913 @default.
- W4362520912 cites W3211727853 @default.
- W4362520912 cites W4200516467 @default.
- W4362520912 cites W4214859637 @default.
- W4362520912 cites W4220961913 @default.
- W4362520912 cites W4282919331 @default.
- W4362520912 cites W4283160423 @default.
- W4362520912 cites W4289779497 @default.
- W4362520912 cites W4292162169 @default.
- W4362520912 cites W4317357896 @default.
- W4362520912 doi "https://doi.org/10.1021/acs.molpharmaceut.3c00074" @default.
- W4362520912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37014780" @default.
- W4362520912 hasPublicationYear "2023" @default.
- W4362520912 type Work @default.
- W4362520912 citedByCount "2" @default.
- W4362520912 countsByYear W43625209122023 @default.
- W4362520912 crossrefType "journal-article" @default.
- W4362520912 hasAuthorship W4362520912A5014575520 @default.
- W4362520912 hasAuthorship W4362520912A5086136904 @default.
- W4362520912 hasAuthorship W4362520912A5087768682 @default.
- W4362520912 hasAuthorship W4362520912A5089190548 @default.
- W4362520912 hasAuthorship W4362520912A5089312926 @default.
- W4362520912 hasConcept C100817775 @default.
- W4362520912 hasConcept C127413603 @default.
- W4362520912 hasConcept C13965031 @default.
- W4362520912 hasConcept C144796933 @default.
- W4362520912 hasConcept C155574463 @default.
- W4362520912 hasConcept C171250308 @default.
- W4362520912 hasConcept C178790620 @default.
- W4362520912 hasConcept C184651966 @default.
- W4362520912 hasConcept C185592680 @default.
- W4362520912 hasConcept C192562407 @default.
- W4362520912 hasConcept C2779257994 @default.
- W4362520912 hasConcept C2779433975 @default.
- W4362520912 hasConcept C42360764 @default.
- W4362520912 hasConcept C43617362 @default.
- W4362520912 hasConcept C521977710 @default.
- W4362520912 hasConcept C71240020 @default.
- W4362520912 hasConcept C91129048 @default.
- W4362520912 hasConceptScore W4362520912C100817775 @default.
- W4362520912 hasConceptScore W4362520912C127413603 @default.
- W4362520912 hasConceptScore W4362520912C13965031 @default.
- W4362520912 hasConceptScore W4362520912C144796933 @default.
- W4362520912 hasConceptScore W4362520912C155574463 @default.
- W4362520912 hasConceptScore W4362520912C171250308 @default.
- W4362520912 hasConceptScore W4362520912C178790620 @default.
- W4362520912 hasConceptScore W4362520912C184651966 @default.
- W4362520912 hasConceptScore W4362520912C185592680 @default.
- W4362520912 hasConceptScore W4362520912C192562407 @default.
- W4362520912 hasConceptScore W4362520912C2779257994 @default.
- W4362520912 hasConceptScore W4362520912C2779433975 @default.