Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362521111> ?p ?o ?g. }
- W4362521111 abstract "Changes in the three-dimensional (3D) structure of the genome are an emerging hallmark of cancer. Cancer-associated copy number variants and single nucleotide polymorphisms promote rewiring of chromatin loops, disruption of topologically associating domains (TADs), active/inactive chromatin state switching, leading to oncogene expression and silencing of tumor suppressors. However, little is known about 3D changes during cancer progression to a chemotherapy-resistant state. We integrated chromatin conformation capture (Hi-C), RNA-seq, and whole-genome sequencing obtained from triple-negative breast cancer patient-derived xenograft primary tumors (UCD52) and carboplatin-resistant samples and found increased short-range (< 2 Mb) interactions, chromatin looping, formation of TAD, chromatin state switching into a more active state, and amplification of ATP-binding cassette transporters. Transcriptome changes suggested the role of long-noncoding RNAs in carboplatin resistance. Rewiring of the 3D genome was associated with TP53, TP63, BATF, FOS-JUN family of transcription factors and led to activation of aggressiveness-, metastasis- and other cancer-related pathways. Integrative analysis highlighted increased ribosome biogenesis and oxidative phosphorylation, suggesting the role of mitochondrial energy metabolism. Our results suggest that 3D genome remodeling may be a key mechanism underlying carboplatin resistance." @default.
- W4362521111 created "2023-04-06" @default.
- W4362521111 creator A5000376105 @default.
- W4362521111 creator A5011260402 @default.
- W4362521111 creator A5036380790 @default.
- W4362521111 creator A5049453725 @default.
- W4362521111 creator A5050674246 @default.
- W4362521111 creator A5053398622 @default.
- W4362521111 creator A5055903772 @default.
- W4362521111 creator A5056470952 @default.
- W4362521111 creator A5057868655 @default.
- W4362521111 creator A5070498170 @default.
- W4362521111 creator A5075170106 @default.
- W4362521111 creator A5077445023 @default.
- W4362521111 creator A5077613865 @default.
- W4362521111 creator A5082616445 @default.
- W4362521111 creator A5088215562 @default.
- W4362521111 creator A5090216964 @default.
- W4362521111 date "2023-04-03" @default.
- W4362521111 modified "2023-09-26" @default.
- W4362521111 title "Rewiring of the 3D genome during acquisition of carboplatin resistance in a triple-negative breast cancer patient-derived xenograft" @default.
- W4362521111 cites W1540173732 @default.
- W4362521111 cites W1859117663 @default.
- W4362521111 cites W1903203327 @default.
- W4362521111 cites W1973062929 @default.
- W4362521111 cites W1981045629 @default.
- W4362521111 cites W2009326542 @default.
- W4362521111 cites W2033346155 @default.
- W4362521111 cites W2036897871 @default.
- W4362521111 cites W2042965279 @default.
- W4362521111 cites W2058977958 @default.
- W4362521111 cites W2065817684 @default.
- W4362521111 cites W2070021921 @default.
- W4362521111 cites W2070050178 @default.
- W4362521111 cites W2082926700 @default.
- W4362521111 cites W2088717951 @default.
- W4362521111 cites W2090037139 @default.
- W4362521111 cites W2096745115 @default.
- W4362521111 cites W2102619694 @default.
- W4362521111 cites W2103441770 @default.
- W4362521111 cites W2107959716 @default.
- W4362521111 cites W2111350087 @default.
- W4362521111 cites W2114104545 @default.
- W4362521111 cites W2115727543 @default.
- W4362521111 cites W2127815633 @default.
- W4362521111 cites W2131478115 @default.
- W4362521111 cites W2134526812 @default.
- W4362521111 cites W2140951889 @default.
- W4362521111 cites W2146005104 @default.
- W4362521111 cites W2147343434 @default.
- W4362521111 cites W2149398604 @default.
- W4362521111 cites W2158789637 @default.
- W4362521111 cites W2158857553 @default.
- W4362521111 cites W2161212572 @default.
- W4362521111 cites W2169456326 @default.
- W4362521111 cites W2175063164 @default.
- W4362521111 cites W2197124664 @default.
- W4362521111 cites W2214074259 @default.
- W4362521111 cites W2216340565 @default.
- W4362521111 cites W2221837786 @default.
- W4362521111 cites W2258488390 @default.
- W4362521111 cites W2267070684 @default.
- W4362521111 cites W2303393194 @default.
- W4362521111 cites W2324665822 @default.
- W4362521111 cites W2481029670 @default.
- W4362521111 cites W2514862430 @default.
- W4362521111 cites W2531767155 @default.
- W4362521111 cites W2533005202 @default.
- W4362521111 cites W2592811885 @default.
- W4362521111 cites W2781829428 @default.
- W4362521111 cites W2791235391 @default.
- W4362521111 cites W2799869370 @default.
- W4362521111 cites W2800852522 @default.
- W4362521111 cites W2884256577 @default.
- W4362521111 cites W2891870314 @default.
- W4362521111 cites W2913116862 @default.
- W4362521111 cites W2924813631 @default.
- W4362521111 cites W2936989468 @default.
- W4362521111 cites W2949421579 @default.
- W4362521111 cites W2949893004 @default.
- W4362521111 cites W2951322997 @default.
- W4362521111 cites W2952940726 @default.
- W4362521111 cites W2998161914 @default.
- W4362521111 cites W2999585791 @default.
- W4362521111 cites W3000300544 @default.
- W4362521111 cites W3004587468 @default.
- W4362521111 cites W3046013264 @default.
- W4362521111 cites W3091034669 @default.
- W4362521111 cites W3092539241 @default.
- W4362521111 cites W3121069500 @default.
- W4362521111 cites W3126638199 @default.
- W4362521111 cites W3127734607 @default.
- W4362521111 cites W3131055609 @default.
- W4362521111 cites W3136560908 @default.
- W4362521111 cites W3154334062 @default.
- W4362521111 cites W3165253641 @default.
- W4362521111 cites W3166957378 @default.
- W4362521111 cites W3173420013 @default.
- W4362521111 cites W3175931262 @default.
- W4362521111 cites W3183894367 @default.