Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362521714> ?p ?o ?g. }
- W4362521714 abstract "The prevalence of obesity and type 2 diabetes is growing at an alarming rate, including among pregnant women. Low-calorie sweeteners (LCS) have increasingly been used as an alternative to sugar to deliver a sweet taste without the excessive caloric load. However, there is little evidence regarding their biological effects, particularly during development. Here, we used a mouse model of maternal LCS consumption to explore the impact of perinatal LCS exposure on the development of neural systems involved in metabolic regulations. We report that adult male, but not female, offspring from both aspartame- and rebaudioside A-exposed dams displayed increased adiposity and developed glucose intolerance. Moreover, maternal LCS consumption reorganized hypothalamic melanocortin circuits and disrupted parasympathetic innervation of pancreatic islets in male offspring. We then identified phenylacetylglycine (PAG) as a unique metabolite that is upregulated in the milk of LCS-fed dams and the serum of their pups. Furthermore, maternal PAG treatment recapitulates some of the key metabolic and neurodevelopmental abnormalities associated with maternal LCS consumption. Together, our data indicate that maternal LCS consumption has enduring consequences on the offspring's metabolism and neural development and that these effects are likely to be mediated through the gut microbial co-metabolite PAG." @default.
- W4362521714 created "2023-04-06" @default.
- W4362521714 creator A5000252017 @default.
- W4362521714 creator A5000603458 @default.
- W4362521714 creator A5000868446 @default.
- W4362521714 creator A5003951466 @default.
- W4362521714 creator A5008816660 @default.
- W4362521714 creator A5013171903 @default.
- W4362521714 creator A5014339990 @default.
- W4362521714 creator A5018860616 @default.
- W4362521714 creator A5038837217 @default.
- W4362521714 creator A5044921868 @default.
- W4362521714 creator A5048758178 @default.
- W4362521714 creator A5060733104 @default.
- W4362521714 creator A5062982950 @default.
- W4362521714 creator A5068754990 @default.
- W4362521714 creator A5089348041 @default.
- W4362521714 date "2023-05-22" @default.
- W4362521714 modified "2023-10-14" @default.
- W4362521714 title "Maternal low-calorie sweetener consumption rewires hypothalamic melanocortin circuits via a gut microbial co-metabolite pathway" @default.
- W4362521714 cites W1516001903 @default.
- W4362521714 cites W1607650002 @default.
- W4362521714 cites W1941626479 @default.
- W4362521714 cites W1964913810 @default.
- W4362521714 cites W1987922392 @default.
- W4362521714 cites W1989947363 @default.
- W4362521714 cites W1993598672 @default.
- W4362521714 cites W1993673692 @default.
- W4362521714 cites W2000728876 @default.
- W4362521714 cites W2012490955 @default.
- W4362521714 cites W2028861833 @default.
- W4362521714 cites W2034285706 @default.
- W4362521714 cites W2052629573 @default.
- W4362521714 cites W2062557665 @default.
- W4362521714 cites W2093088433 @default.
- W4362521714 cites W2103761010 @default.
- W4362521714 cites W2106505481 @default.
- W4362521714 cites W2111074526 @default.
- W4362521714 cites W2115701239 @default.
- W4362521714 cites W2121300620 @default.
- W4362521714 cites W2125318007 @default.
- W4362521714 cites W2126440147 @default.
- W4362521714 cites W2127124396 @default.
- W4362521714 cites W2149456526 @default.
- W4362521714 cites W2149515881 @default.
- W4362521714 cites W2153719617 @default.
- W4362521714 cites W2160182726 @default.
- W4362521714 cites W2303302208 @default.
- W4362521714 cites W2334739015 @default.
- W4362521714 cites W2346523840 @default.
- W4362521714 cites W2401404581 @default.
- W4362521714 cites W2515946872 @default.
- W4362521714 cites W2527620528 @default.
- W4362521714 cites W2571440114 @default.
- W4362521714 cites W2623661376 @default.
- W4362521714 cites W2710755934 @default.
- W4362521714 cites W2726533508 @default.
- W4362521714 cites W2767092221 @default.
- W4362521714 cites W2774551105 @default.
- W4362521714 cites W2789863794 @default.
- W4362521714 cites W2790799311 @default.
- W4362521714 cites W2908438355 @default.
- W4362521714 cites W2952037616 @default.
- W4362521714 cites W2994672341 @default.
- W4362521714 cites W3003310274 @default.
- W4362521714 cites W3008887685 @default.
- W4362521714 cites W3009682272 @default.
- W4362521714 cites W3011564950 @default.
- W4362521714 cites W3015867338 @default.
- W4362521714 cites W3016659671 @default.
- W4362521714 cites W3020161996 @default.
- W4362521714 cites W3022593374 @default.
- W4362521714 cites W3086747701 @default.
- W4362521714 cites W3088211674 @default.
- W4362521714 cites W3115118069 @default.
- W4362521714 cites W3134781470 @default.
- W4362521714 cites W3198905500 @default.
- W4362521714 cites W3202064144 @default.
- W4362521714 cites W4206355619 @default.
- W4362521714 cites W4251288475 @default.
- W4362521714 cites W4252731434 @default.
- W4362521714 doi "https://doi.org/10.1172/jci.insight.156397" @default.
- W4362521714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37014702" @default.
- W4362521714 hasPublicationYear "2023" @default.
- W4362521714 type Work @default.
- W4362521714 citedByCount "4" @default.
- W4362521714 countsByYear W43625217142023 @default.
- W4362521714 crossrefType "journal-article" @default.
- W4362521714 hasAuthorship W4362521714A5000252017 @default.
- W4362521714 hasAuthorship W4362521714A5000603458 @default.
- W4362521714 hasAuthorship W4362521714A5000868446 @default.
- W4362521714 hasAuthorship W4362521714A5003951466 @default.
- W4362521714 hasAuthorship W4362521714A5008816660 @default.
- W4362521714 hasAuthorship W4362521714A5013171903 @default.
- W4362521714 hasAuthorship W4362521714A5014339990 @default.
- W4362521714 hasAuthorship W4362521714A5018860616 @default.
- W4362521714 hasAuthorship W4362521714A5038837217 @default.
- W4362521714 hasAuthorship W4362521714A5044921868 @default.
- W4362521714 hasAuthorship W4362521714A5048758178 @default.
- W4362521714 hasAuthorship W4362521714A5060733104 @default.