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- W4362522137 abstract "Based on the concept of tissue engineering (Cells-Scaffold-Bioactive molecules), regenerative endodontics appeared as a new notion for dental endodontic treatment. Its approaches aim to preserve dental pulp vitality (pulp capping) or to regenerate a vascularized pulp-like tissue inside necrotic root canals by cell homing. To improve the methods of tissue engineering for pulp regeneration, numerous studies using in vitro, ex vivo, and in vivo models have been performed. This review explores the evolution of laboratory models used in such studies and classifies them according to different criteria. It starts from the initial two-dimensional in vitro models that allowed characterization of stem cell behavior, through 3D culture matrices combined with dental tissue and finally arrives at the more challenging ex vivo and in vivo models. The travel which follows the elaboration of such models reveals the difficulty in establishing reproducible laboratory models for dental pulp regeneration. The development of well-established protocols and new laboratory ex vivo and in vivo models in the field of pulp regeneration would lead to consistent results, reduction of animal experimentation, and facilitation of the translation to clinical practice." @default.
- W4362522137 created "2023-04-06" @default.
- W4362522137 creator A5015160349 @default.
- W4362522137 creator A5036909308 @default.
- W4362522137 creator A5038938912 @default.
- W4362522137 creator A5065003049 @default.
- W4362522137 creator A5065204565 @default.
- W4362522137 creator A5086022935 @default.
- W4362522137 date "2023-04-01" @default.
- W4362522137 modified "2023-09-30" @default.
- W4362522137 title "In vitro, ex vivo, and in vivo models for dental pulp regeneration" @default.
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