FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362523547> ?p ?o ?g. }

• W4362523547 abstract "Abstract Background Filamentous fungi with the ability to use complex carbon sources has been developed as platforms for biochemicals production. Myceliophthora thermophila has been developed as the cell factory to produce lignocellulolytic enzymes and plant biomass-based biofuels and biochemicals in biorefinery. However, low fungal growth rate and cellulose utilization efficiency are significant barriers to the satisfactory yield and productivity of target products, which needs our further exploration and improvement. Results In this study, we comprehensively explored the roles of the putative methyltransferase LaeA in regulating mycelium growth, sugar consumption, and cellulases expression. Deletion of laeA in thermophile fungus Myceliophthora thermophila enhanced mycelium growth and glucose consumption significantly. Further exploration of LaeA regulatory network indicated that multiple growth regulatory factors (GRF) Cre-1, Grf-1, Grf-2, and Grf-3, which act as negative repressors of carbon metabolism, were regulated by LaeA in this fungus. We also determined that phosphoenolpyruvate carboxykinase (PCK) is the core node of the metabolic network related to fungal vegetative growth, of which enhancement partially contributed to the elevated sugar consumption and fungal growth of mutant Δ laeA . Noteworthily, LaeA participated in regulating the expression of cellulase genes and their transcription regulator. Δ laeA exhibited 30.6% and 5.5% increases in the peak values of extracellular protein and endo-glucanase activity, respectively, as compared to the WT strain. Furthermore, the global histone methylation assays indicated that LaeA is associated with modulating H3K9 methylation levels. The normal function of LaeA on regulating fungal physiology is dependent on methyltransferase activity. Conclusions The research presented in this study clarified the function and elucidated the regulatory network of LaeA in the regulation of fungal growth and cellulase production, which will significantly deepen our understanding about the regulation mechanism of LaeA in filamentous fungi and provides the new strategy for improvement the fermentation properties of industrial fungal strain by metabolic engineering." @default.
• W4362523547 created "2023-04-06" @default.
• W4362523547 creator A5004484189 @default.
• W4362523547 creator A5006349365 @default.
• W4362523547 creator A5031687398 @default.
• W4362523547 creator A5039360592 @default.
• W4362523547 creator A5039467147 @default.
• W4362523547 creator A5070236922 @default.
• W4362523547 creator A5076061762 @default.
• W4362523547 date "2023-04-03" @default.
• W4362523547 modified "2023-10-17" @default.
• W4362523547 title "The putative methyltransferase LaeA regulates mycelium growth and cellulase production in Myceliophthora thermophila" @default.
• W4362523547 cites W1423319670 @default.
• W4362523547 cites W1465481699 @default.
• W4362523547 cites W1559150972 @default.
• W4362523547 cites W1852807937 @default.
• W4362523547 cites W1879352431 @default.
• W4362523547 cites W1883731916 @default.
• W4362523547 cites W1936378126 @default.
• W4362523547 cites W1965369408 @default.
• W4362523547 cites W1969149088 @default.
• W4362523547 cites W1979157667 @default.
• W4362523547 cites W1981449030 @default.
• W4362523547 cites W1983706449 @default.
• W4362523547 cites W1985445406 @default.
• W4362523547 cites W2010625410 @default.
• W4362523547 cites W2012447359 @default.
• W4362523547 cites W2018652426 @default.
• W4362523547 cites W2018878486 @default.
• W4362523547 cites W2024109444 @default.
• W4362523547 cites W2045444560 @default.
• W4362523547 cites W2055770801 @default.
• W4362523547 cites W2077055748 @default.
• W4362523547 cites W2096261603 @default.
• W4362523547 cites W2098489069 @default.
• W4362523547 cites W2104020718 @default.
• W4362523547 cites W2106932184 @default.
• W4362523547 cites W2114580691 @default.
• W4362523547 cites W2119787018 @default.
• W4362523547 cites W2120320979 @default.
• W4362523547 cites W2124494829 @default.
• W4362523547 cites W2152239989 @default.
• W4362523547 cites W2157966065 @default.
• W4362523547 cites W2159269304 @default.
• W4362523547 cites W2168304891 @default.
• W4362523547 cites W2168785486 @default.
• W4362523547 cites W2170019188 @default.
• W4362523547 cites W2191372796 @default.
• W4362523547 cites W2207182837 @default.
• W4362523547 cites W2373547848 @default.
• W4362523547 cites W2462787445 @default.
• W4362523547 cites W2560946397 @default.
• W4362523547 cites W2561030438 @default.
• W4362523547 cites W2571966499 @default.
• W4362523547 cites W2610179691 @default.
• W4362523547 cites W2622546568 @default.
• W4362523547 cites W2734490137 @default.
• W4362523547 cites W2779939194 @default.
• W4362523547 cites W2796629542 @default.
• W4362523547 cites W2903052322 @default.
• W4362523547 cites W2903545169 @default.
• W4362523547 cites W2943978406 @default.
• W4362523547 cites W2944024959 @default.
• W4362523547 cites W2981611533 @default.
• W4362523547 cites W2992236525 @default.
• W4362523547 cites W2994711892 @default.
• W4362523547 cites W2995147125 @default.
• W4362523547 cites W3008990042 @default.
• W4362523547 cites W3011379747 @default.
• W4362523547 cites W3014294465 @default.
• W4362523547 cites W3049224465 @default.
• W4362523547 cites W3122417685 @default.
• W4362523547 cites W3163675482 @default.
• W4362523547 cites W4206012674 @default.
• W4362523547 cites W4207041917 @default.
• W4362523547 cites W4211010290 @default.
• W4362523547 doi "https://doi.org/10.1186/s13068-023-02313-3" @default.
• W4362523547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37013645" @default.
• W4362523547 hasPublicationYear "2023" @default.
• W4362523547 type Work @default.
• W4362523547 citedByCount "1" @default.
• W4362523547 countsByYear W43625235472023 @default.
• W4362523547 crossrefType "journal-article" @default.
• W4362523547 hasAuthorship W4362523547A5004484189 @default.
• W4362523547 hasAuthorship W4362523547A5006349365 @default.
• W4362523547 hasAuthorship W4362523547A5031687398 @default.
• W4362523547 hasAuthorship W4362523547A5039360592 @default.
• W4362523547 hasAuthorship W4362523547A5039467147 @default.
• W4362523547 hasAuthorship W4362523547A5070236922 @default.
• W4362523547 hasAuthorship W4362523547A5076061762 @default.
• W4362523547 hasBestOaLocation W43625235471 @default.
• W4362523547 hasConcept C104317684 @default.
• W4362523547 hasConcept C133479454 @default.
• W4362523547 hasConcept C143065580 @default.
• W4362523547 hasConcept C2910135453 @default.
• W4362523547 hasConcept C55493867 @default.
• W4362523547 hasConcept C59822182 @default.
• W4362523547 hasConcept C86803240 @default.
• W4362523547 hasConceptScore W4362523547C104317684 @default.
• W4362523547 hasConceptScore W4362523547C133479454 @default.

• next