FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362523816> ?p ?o ?g. }

• W4362523816 endingPage "817" @default.
• W4362523816 startingPage "809" @default.
• W4362523816 abstract "Human gut microbiome has complex relationships with the host, contributing to metabolism, immunity, and carcinogenesis.Summary-level data for gut microbiota and metabolites were obtained from MiBioGen, FINRISK and human metabolome consortia. Summary-level data for colorectal cancer were derived from a genome-wide association study meta-analysis. In forward Mendelian randomization (MR), we employed genetic instrumental variables (IV) for 24 gut microbiota taxa and six bacterial metabolites to examine their causal relationship with colorectal cancer. We also used a lenient threshold for nine apriori gut microbiota taxa as secondary analyses. In reverse MR, we explored association between genetic liability to colorectal neoplasia and abundance of microbiota studied above using 95, 19, and 7 IVs for colorectal cancer, adenoma, and polyps, respectively.Forward MR did not find evidence indicating causal relationship between any of the gut microbiota taxa or six bacterial metabolites tested and colorectal cancer risk. However, reverse MR supported genetic liability to colorectal adenomas was causally related with increased abundance of two taxa: Gammaproteobacteria (β = 0.027, which represents a 0.027 increase in log-transformed relative abundance values of Gammaproteobacteria for per one-unit increase in log OR of adenoma risk; P = 7.06×10-8), Enterobacteriaceae (β = 0.023, P = 1.29×10-5).We find genetic liability to colorectal neoplasia may be associated with abundance of certain microbiota taxa. It is more likely that subset of colorectal cancer genetic liability variants changes gut biology by influencing both gut microbiota and colorectal cancer risk.This study highlights the need of future complementary studies to explore causal mechanisms linking both host genetic variation with gut microbiome and colorectal cancer susceptibility." @default.
• W4362523816 created "2023-04-06" @default.
• W4362523816 creator A5002415589 @default.
• W4362523816 creator A5007530177 @default.
• W4362523816 creator A5012271115 @default.
• W4362523816 creator A5016100282 @default.
• W4362523816 creator A5016841707 @default.
• W4362523816 creator A5020534921 @default.
• W4362523816 creator A5022550644 @default.
• W4362523816 creator A5032057540 @default.
• W4362523816 creator A5035316294 @default.
• W4362523816 creator A5040598662 @default.
• W4362523816 creator A5042121394 @default.
• W4362523816 creator A5042479265 @default.
• W4362523816 creator A5051183004 @default.
• W4362523816 creator A5051387435 @default.
• W4362523816 creator A5074591909 @default.
• W4362523816 creator A5076117969 @default.
• W4362523816 creator A5076350483 @default.
• W4362523816 creator A5078567214 @default.
• W4362523816 creator A5081262769 @default.
• W4362523816 creator A5090235061 @default.
• W4362523816 date "2023-04-03" @default.
• W4362523816 modified "2023-10-15" @default.
• W4362523816 title "Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis" @default.
• W4362523816 cites W1518469225 @default.
• W4362523816 cites W1993018723 @default.
• W4362523816 cites W2012151682 @default.
• W4362523816 cites W2013354102 @default.
• W4362523816 cites W2098604445 @default.
• W4362523816 cites W2106036991 @default.
• W4362523816 cites W2113699335 @default.
• W4362523816 cites W2122790967 @default.
• W4362523816 cites W2132406938 @default.
• W4362523816 cites W2136111918 @default.
• W4362523816 cites W2140679462 @default.
• W4362523816 cites W2166082348 @default.
• W4362523816 cites W2262330054 @default.
• W4362523816 cites W2324862792 @default.
• W4362523816 cites W2404101934 @default.
• W4362523816 cites W2564393024 @default.
• W4362523816 cites W2594360546 @default.
• W4362523816 cites W2755380156 @default.
• W4362523816 cites W2803072880 @default.
• W4362523816 cites W2803947549 @default.
• W4362523816 cites W2805983714 @default.
• W4362523816 cites W2897162527 @default.
• W4362523816 cites W2900205080 @default.
• W4362523816 cites W2903428492 @default.
• W4362523816 cites W2903533144 @default.
• W4362523816 cites W2909668868 @default.
• W4362523816 cites W2913914265 @default.
• W4362523816 cites W2926356503 @default.
• W4362523816 cites W2944046200 @default.
• W4362523816 cites W2977433364 @default.
• W4362523816 cites W2982543307 @default.
• W4362523816 cites W3000710679 @default.
• W4362523816 cites W3022309178 @default.
• W4362523816 cites W3027658010 @default.
• W4362523816 cites W3040806267 @default.
• W4362523816 cites W3080629813 @default.
• W4362523816 cites W3120099202 @default.
• W4362523816 cites W3121407008 @default.
• W4362523816 cites W3125898497 @default.
• W4362523816 cites W3128646645 @default.
• W4362523816 cites W3175428430 @default.
• W4362523816 cites W3195705894 @default.
• W4362523816 cites W4200130396 @default.
• W4362523816 cites W4200287074 @default.
• W4362523816 cites W4211199921 @default.
• W4362523816 cites W4220680754 @default.
• W4362523816 cites W4225854522 @default.
• W4362523816 doi "https://doi.org/10.1158/1055-9965.epi-22-0724" @default.
• W4362523816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37012201" @default.
• W4362523816 hasPublicationYear "2023" @default.
• W4362523816 type Work @default.
• W4362523816 citedByCount "2" @default.
• W4362523816 countsByYear W43625238162023 @default.
• W4362523816 crossrefType "journal-article" @default.
• W4362523816 hasAuthorship W4362523816A5002415589 @default.
• W4362523816 hasAuthorship W4362523816A5007530177 @default.
• W4362523816 hasAuthorship W4362523816A5012271115 @default.
• W4362523816 hasAuthorship W4362523816A5016100282 @default.
• W4362523816 hasAuthorship W4362523816A5016841707 @default.
• W4362523816 hasAuthorship W4362523816A5020534921 @default.
• W4362523816 hasAuthorship W4362523816A5022550644 @default.
• W4362523816 hasAuthorship W4362523816A5032057540 @default.
• W4362523816 hasAuthorship W4362523816A5035316294 @default.
• W4362523816 hasAuthorship W4362523816A5040598662 @default.
• W4362523816 hasAuthorship W4362523816A5042121394 @default.
• W4362523816 hasAuthorship W4362523816A5042479265 @default.
• W4362523816 hasAuthorship W4362523816A5051183004 @default.
• W4362523816 hasAuthorship W4362523816A5051387435 @default.
• W4362523816 hasAuthorship W4362523816A5074591909 @default.
• W4362523816 hasAuthorship W4362523816A5076117969 @default.
• W4362523816 hasAuthorship W4362523816A5076350483 @default.
• W4362523816 hasAuthorship W4362523816A5078567214 @default.
• W4362523816 hasAuthorship W4362523816A5081262769 @default.

• next