Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362524957> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4362524957 abstract "<div>Abstract<p>Persistent activation of the latent transcription factor STAT3 is observed in gastric tumor epithelial and immune cells and is associated with a poor patient prognosis. Although targeting STAT3-activating upstream kinases offers therapeutically viable targets with limited specificity, direct inhibition of STAT3 remains challenging. Here we provide functional evidence that myeloid-specific hematopoietic cell kinase (HCK) activity can drive STAT3-dependent epithelial tumor growth in mice and is associated with alternative macrophage activation alongside matrix remodeling and tumor cell invasion. Accordingly, genetic reduction of HCK expression in bone marrow–derived cells or systemic pharmacologic inhibition of HCK activity suppresses alternative macrophage polarization and epithelial STAT3 activation, and impairs tumor growth. These data validate HCK as a molecular target for the treatment of human solid tumors harboring excessive STAT3 activity.</p></div>" @default.
- W4362524957 created "2023-04-06" @default.
- W4362524957 creator A5010728148 @default.
- W4362524957 creator A5017657101 @default.
- W4362524957 creator A5025153030 @default.
- W4362524957 creator A5031554487 @default.
- W4362524957 creator A5035050701 @default.
- W4362524957 creator A5043235494 @default.
- W4362524957 creator A5043744905 @default.
- W4362524957 creator A5045827195 @default.
- W4362524957 creator A5048288918 @default.
- W4362524957 creator A5049369672 @default.
- W4362524957 creator A5050050272 @default.
- W4362524957 creator A5052705376 @default.
- W4362524957 creator A5067242663 @default.
- W4362524957 creator A5082818365 @default.
- W4362524957 date "2023-04-04" @default.
- W4362524957 modified "2023-10-16" @default.
- W4362524957 title "Data from Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice" @default.
- W4362524957 doi "https://doi.org/10.1158/2326-6066.c.6550074" @default.
- W4362524957 hasPublicationYear "2023" @default.
- W4362524957 type Work @default.
- W4362524957 citedByCount "0" @default.
- W4362524957 crossrefType "posted-content" @default.
- W4362524957 hasAuthorship W4362524957A5010728148 @default.
- W4362524957 hasAuthorship W4362524957A5017657101 @default.
- W4362524957 hasAuthorship W4362524957A5025153030 @default.
- W4362524957 hasAuthorship W4362524957A5031554487 @default.
- W4362524957 hasAuthorship W4362524957A5035050701 @default.
- W4362524957 hasAuthorship W4362524957A5043235494 @default.
- W4362524957 hasAuthorship W4362524957A5043744905 @default.
- W4362524957 hasAuthorship W4362524957A5045827195 @default.
- W4362524957 hasAuthorship W4362524957A5048288918 @default.
- W4362524957 hasAuthorship W4362524957A5049369672 @default.
- W4362524957 hasAuthorship W4362524957A5050050272 @default.
- W4362524957 hasAuthorship W4362524957A5052705376 @default.
- W4362524957 hasAuthorship W4362524957A5067242663 @default.
- W4362524957 hasAuthorship W4362524957A5082818365 @default.
- W4362524957 hasConcept C108636557 @default.
- W4362524957 hasConcept C109159458 @default.
- W4362524957 hasConcept C184235292 @default.
- W4362524957 hasConcept C185592680 @default.
- W4362524957 hasConcept C203014093 @default.
- W4362524957 hasConcept C2778923194 @default.
- W4362524957 hasConcept C2779282312 @default.
- W4362524957 hasConcept C28328180 @default.
- W4362524957 hasConcept C502942594 @default.
- W4362524957 hasConcept C62478195 @default.
- W4362524957 hasConcept C86803240 @default.
- W4362524957 hasConcept C95444343 @default.
- W4362524957 hasConceptScore W4362524957C108636557 @default.
- W4362524957 hasConceptScore W4362524957C109159458 @default.
- W4362524957 hasConceptScore W4362524957C184235292 @default.
- W4362524957 hasConceptScore W4362524957C185592680 @default.
- W4362524957 hasConceptScore W4362524957C203014093 @default.
- W4362524957 hasConceptScore W4362524957C2778923194 @default.
- W4362524957 hasConceptScore W4362524957C2779282312 @default.
- W4362524957 hasConceptScore W4362524957C28328180 @default.
- W4362524957 hasConceptScore W4362524957C502942594 @default.
- W4362524957 hasConceptScore W4362524957C62478195 @default.
- W4362524957 hasConceptScore W4362524957C86803240 @default.
- W4362524957 hasConceptScore W4362524957C95444343 @default.
- W4362524957 hasLocation W43625249571 @default.
- W4362524957 hasOpenAccess W4362524957 @default.
- W4362524957 hasPrimaryLocation W43625249571 @default.
- W4362524957 hasRelatedWork W1837026174 @default.
- W4362524957 hasRelatedWork W1977287641 @default.
- W4362524957 hasRelatedWork W1986583933 @default.
- W4362524957 hasRelatedWork W1996112634 @default.
- W4362524957 hasRelatedWork W2016433285 @default.
- W4362524957 hasRelatedWork W2018643603 @default.
- W4362524957 hasRelatedWork W2115533799 @default.
- W4362524957 hasRelatedWork W2119511363 @default.
- W4362524957 hasRelatedWork W2569248298 @default.
- W4362524957 hasRelatedWork W2575380761 @default.
- W4362524957 isParatext "false" @default.
- W4362524957 isRetracted "false" @default.
- W4362524957 workType "article" @default.