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- W4362527174 abstract "<p>Fig S1. ELISA formats for detection of various analytes. Fig S2. Biophysical characterization of CAT-02-106. Fig S3. Competitive ELISA data showing CAT-02-106 binding to CD22. Fig S4. CAT-02-106 internalization on Ramos, Granta-519, and WSU-DLCL2 cells. Fig S5. CAT-02-106 in vitro cytotoxicity test on CD22-negative cells. Fig S6. The CAT-02-106-related ADC, anti-HER2 RED-106, does not induce bystander killing. Fig S7. Comparison of cell surface CD22 expression levels on Ramos and WSU-DLCL2 cells. Fig S8. Ramos and WSU-DLCL2 xenograft study data plotted as individual animals. Fig S9. Mouse body weights from Ramos and WSU-DLCL2 xenograft studies. Fig S10. CAT-02-106 binding to cynomolgus monkey B cells as assessed by flow cytometry. Fig S11. CAT-02-106 cross-reactivity to human and cynomolgus tissues. Table S1. Summary of pharmacokinetic findings in rats dosed at 3 mg/kg with CAT-02-106.</p>" @default.
- W4362527174 created "2023-04-06" @default.
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- W4362527174 date "2023-04-03" @default.
- W4362527174 modified "2023-09-26" @default.
- W4362527174 title "Figures S1-S11, Table S1 from CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models" @default.
- W4362527174 doi "https://doi.org/10.1158/1535-7163.22504890" @default.
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