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- W4362534435 abstract "<p>Table S1. Summary of status of tumors used in cell line and patient-derived xenograft models. Table S2. SYD985 and T-DM1 IC50, 95% confidence interval and % efficacy values from the in vitro cytotoxicity assays as depicted in Figure 1B. Table S3. Pharmacokinetic parameters for ADC (SYD985 and T-DM1) in BT-474-tumor-bearing mice after a single i.v. bolus injection of ADC. Figure S1. In vitro cytotoxicity. Figure S2. A-G HER2 expression in BT-474. Figure S3. HER2 cell surface expression quantified on a panel of 8 cell lines using the DAKO Qifikit. Figure S4. In vitro cytotoxicity. Figure S5. In vitro bystander killing. Figure S6. Mean ADC (SYD985 conjugated antibody) concentrations in plasma in carboxylesterase CES1c knock-out (-/-) , CES1c heterozygeous (+/-) and CES1c wild type (+/+) mice, after single i.v. bolus injection of SYD985 at 5 mg/kg (+/- SEM, n = 3).</p>" @default.
- W4362534435 created "2023-04-06" @default.
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- W4362534435 date "2023-04-03" @default.
- W4362534435 modified "2023-10-18" @default.
- W4362534435 title "Supplementary Tables 1 through 3 and Supplementary Figures 1 through 6 from The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers" @default.
- W4362534435 doi "https://doi.org/10.1158/1535-7163.22501852.v1" @default.
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