FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362541399> ?p ?o ?g. }

• W4362541399 endingPage "2811" @default.
• W4362541399 startingPage "2811" @default.
• W4362541399 abstract "Abstract Lung cancer is the main cause of cancer-related mortality, of which non-small cell lung cancer (NSCLC) accounts for 85%. Abemaciclib, a selective CDK4/6 inhibitor, enhanced the radiosensitivity of NSCLC in vivo and in vitro and improved the prognosis of advanced NSCLC patients according to a Phase I clinical trial. This study aimed to explore the impact of CDK4/6 inhibition combined with irradiation and immunotherapy on NSCLC. The in vivo xenograft tumor mouse model was used to investigate the synergistic effects of CDK4/6 inhibitor abemaciclib and irradiation together with anti-PD-1 antibodies. The tumor infiltrating lymphocytes (TILs) in tumor microenvironment (TME) were analyzed by flow cytometry. The complete blood count and serum tests were used to determine the safety of this combination therapy. The human phospho-kinase array and dual-luciferase report assay were used to study the regulatory mechanisms of abemaciclib and irradiation combination on PD-L1 transcription in NSCLC cells in vitro. Our results indicated the significantly synergistic effects of abemaciclib, irradiation and anti-PD-1 antibodies on NSCLC growth in vivo, accompanied by increased CD8+ T cell infiltration and decreased regulatory T cells and myeloid-derived suppressor cells (MDSCs), suggesting a strong anti-tumor combination of CDK4/6 inhibition, radiotherapy and immunotherapy. This synergistic effect could be partially impaired by CD8 depletion, and alleviated the anemia and inflammation caused by tumor burden without hepatorenal toxicity. Abemaciclib induced PD-L1 transcription through JNK/c-Jun pathway in vitro, which might elevate PD-L1 expression synergistically with irradiation through TBK1/IRF3 pathway. Our studies suggested that CDK4/6 inhibition plus irradiation enhanced anti-tumor immune responses in NSCLC. Together with immunotherapy, the combination of CDK4/6 inhibitors and radiotherapy could lower the doses of individual treatment, thus alleviating the potential toxicity and side effects of CDK4/6 inhibition and irradiation on normal cells. Citation Format: Zhengrong Huang, Jiang Luo, Mengqin Wang, Hongxin Xie, Yuxin Zeng, Yu Yuan, Wan Xiang, Ziyu Jiang, Conghua Xie, Yan Gong. CDK4/6 inhibition plus radiotherapy enhances anti-tumor immunity in non-small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2811." @default.
• W4362541399 created "2023-04-06" @default.
• W4362541399 creator A5000769103 @default.
• W4362541399 creator A5031373515 @default.
• W4362541399 creator A5033207995 @default.
• W4362541399 creator A5046406620 @default.
• W4362541399 creator A5047747090 @default.
• W4362541399 creator A5050504830 @default.
• W4362541399 creator A5058963598 @default.
• W4362541399 creator A5064737783 @default.
• W4362541399 creator A5070521893 @default.
• W4362541399 creator A5074911249 @default.
• W4362541399 date "2023-04-04" @default.
• W4362541399 modified "2023-10-01" @default.
• W4362541399 title "Abstract 2811: CDK4/6 inhibition plus radiotherapy enhances anti-tumor immunity in non-small cell lung cancer" @default.
• W4362541399 doi "https://doi.org/10.1158/1538-7445.am2023-2811" @default.
• W4362541399 hasPublicationYear "2023" @default.
• W4362541399 type Work @default.
• W4362541399 citedByCount "0" @default.
• W4362541399 crossrefType "journal-article" @default.
• W4362541399 hasAuthorship W4362541399A5000769103 @default.
• W4362541399 hasAuthorship W4362541399A5031373515 @default.
• W4362541399 hasAuthorship W4362541399A5033207995 @default.
• W4362541399 hasAuthorship W4362541399A5046406620 @default.
• W4362541399 hasAuthorship W4362541399A5047747090 @default.
• W4362541399 hasAuthorship W4362541399A5050504830 @default.
• W4362541399 hasAuthorship W4362541399A5058963598 @default.
• W4362541399 hasAuthorship W4362541399A5064737783 @default.
• W4362541399 hasAuthorship W4362541399A5070521893 @default.
• W4362541399 hasAuthorship W4362541399A5074911249 @default.
• W4362541399 hasConcept C121608353 @default.
• W4362541399 hasConcept C126322002 @default.
• W4362541399 hasConcept C150903083 @default.
• W4362541399 hasConcept C167672396 @default.
• W4362541399 hasConcept C203014093 @default.
• W4362541399 hasConcept C207001950 @default.
• W4362541399 hasConcept C2776107976 @default.
• W4362541399 hasConcept C2776256026 @default.
• W4362541399 hasConcept C2777701055 @default.
• W4362541399 hasConcept C502942594 @default.
• W4362541399 hasConcept C71924100 @default.
• W4362541399 hasConcept C86803240 @default.
• W4362541399 hasConcept C8891405 @default.
• W4362541399 hasConceptScore W4362541399C121608353 @default.
• W4362541399 hasConceptScore W4362541399C126322002 @default.
• W4362541399 hasConceptScore W4362541399C150903083 @default.
• W4362541399 hasConceptScore W4362541399C167672396 @default.
• W4362541399 hasConceptScore W4362541399C203014093 @default.
• W4362541399 hasConceptScore W4362541399C207001950 @default.
• W4362541399 hasConceptScore W4362541399C2776107976 @default.
• W4362541399 hasConceptScore W4362541399C2776256026 @default.
• W4362541399 hasConceptScore W4362541399C2777701055 @default.
• W4362541399 hasConceptScore W4362541399C502942594 @default.
• W4362541399 hasConceptScore W4362541399C71924100 @default.
• W4362541399 hasConceptScore W4362541399C86803240 @default.
• W4362541399 hasConceptScore W4362541399C8891405 @default.
• W4362541399 hasIssue "7_Supplement" @default.
• W4362541399 hasLocation W43625413991 @default.
• W4362541399 hasOpenAccess W4362541399 @default.
• W4362541399 hasPrimaryLocation W43625413991 @default.
• W4362541399 hasRelatedWork W2178868239 @default.
• W4362541399 hasRelatedWork W2771066073 @default.
• W4362541399 hasRelatedWork W3123929348 @default.
• W4362541399 hasRelatedWork W3190645866 @default.
• W4362541399 hasRelatedWork W3195008613 @default.
• W4362541399 hasRelatedWork W4303613753 @default.
• W4362541399 hasRelatedWork W4308595649 @default.
• W4362541399 hasRelatedWork W4308769187 @default.
• W4362541399 hasRelatedWork W4312075079 @default.
• W4362541399 hasRelatedWork W4360869587 @default.
• W4362541399 hasVolume "83" @default.
• W4362541399 isParatext "false" @default.
• W4362541399 isRetracted "false" @default.
• W4362541399 workType "article" @default.