Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362545137> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4362545137 abstract "<div>Abstract<p>Complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing protein 1 (CDCP1) is a transmembrane protein that regulates anchorage-independent growth and cancer cell migration and invasion. Expression of CDCP1 is detected in a number of cancer cell lines and tissues and is closely correlated with poor prognosis. Invadopodia are actin-based protrusions on the surface of invasive cancer cells that promote the degradation of the extracellular matrix (ECM) via localized proteolysis, which is mainly mediated by membrane type 1 matrix metalloproteinase (MT1-MMP). MT1-MMP is accumulated at invadopodia by targeted delivery via membrane trafficking. The present study shows that CDCP1 is required for ECM degradation by invadopodia in human breast cancer and melanoma cells. CDCP1 localized to caveolin-1–containing vesicular structures and lipid rafts and was detected in close proximity to invadopodia. Further biochemical analysis revealed that substantial amounts of CDCP1 existed in the Triton X-100 insoluble lipid raft fraction. CDCP1 was coimmunoprecipitated with MT1-MMP and colocalized with MT1-MMP at the vesicular structures. The siRNA-mediated knockdown of the CDCP1 expression markedly inhibited MT1-MMP–dependent ECM degradation and Matrigel invasion and reduced the accumulation of MT1-MMP at invadopodia, as shown by immunofluorescence analysis. These results indicate that CDCP1 is an essential regulator of the trafficking and function of MT1-MMP- and invadopodia-mediated invasion of cancer cells. <i>Mol Cancer Res; 11(6); 628–37. ©2013 AACR</i>.</p></div>" @default.
- W4362545137 created "2023-04-06" @default.
- W4362545137 creator A5004010569 @default.
- W4362545137 creator A5008902984 @default.
- W4362545137 creator A5043738488 @default.
- W4362545137 creator A5048937697 @default.
- W4362545137 creator A5075374287 @default.
- W4362545137 creator A5076020482 @default.
- W4362545137 date "2023-04-03" @default.
- W4362545137 modified "2023-09-26" @default.
- W4362545137 title "Data from CDCP1 Regulates the Function of MT1-MMP and Invadopodia-Mediated Invasion of Cancer Cells" @default.
- W4362545137 doi "https://doi.org/10.1158/1541-7786.c.6539592" @default.
- W4362545137 hasPublicationYear "2023" @default.
- W4362545137 type Work @default.
- W4362545137 citedByCount "0" @default.
- W4362545137 crossrefType "posted-content" @default.
- W4362545137 hasAuthorship W4362545137A5004010569 @default.
- W4362545137 hasAuthorship W4362545137A5008902984 @default.
- W4362545137 hasAuthorship W4362545137A5043738488 @default.
- W4362545137 hasAuthorship W4362545137A5048937697 @default.
- W4362545137 hasAuthorship W4362545137A5075374287 @default.
- W4362545137 hasAuthorship W4362545137A5076020482 @default.
- W4362545137 hasConcept C109523444 @default.
- W4362545137 hasConcept C121608353 @default.
- W4362545137 hasConcept C141073059 @default.
- W4362545137 hasConcept C142669718 @default.
- W4362545137 hasConcept C1491633281 @default.
- W4362545137 hasConcept C173396325 @default.
- W4362545137 hasConcept C185592680 @default.
- W4362545137 hasConcept C189165786 @default.
- W4362545137 hasConcept C190283241 @default.
- W4362545137 hasConcept C200786668 @default.
- W4362545137 hasConcept C502942594 @default.
- W4362545137 hasConcept C54355233 @default.
- W4362545137 hasConcept C55493867 @default.
- W4362545137 hasConcept C62478195 @default.
- W4362545137 hasConcept C79266657 @default.
- W4362545137 hasConcept C86803240 @default.
- W4362545137 hasConcept C95444343 @default.
- W4362545137 hasConcept C96232424 @default.
- W4362545137 hasConceptScore W4362545137C109523444 @default.
- W4362545137 hasConceptScore W4362545137C121608353 @default.
- W4362545137 hasConceptScore W4362545137C141073059 @default.
- W4362545137 hasConceptScore W4362545137C142669718 @default.
- W4362545137 hasConceptScore W4362545137C1491633281 @default.
- W4362545137 hasConceptScore W4362545137C173396325 @default.
- W4362545137 hasConceptScore W4362545137C185592680 @default.
- W4362545137 hasConceptScore W4362545137C189165786 @default.
- W4362545137 hasConceptScore W4362545137C190283241 @default.
- W4362545137 hasConceptScore W4362545137C200786668 @default.
- W4362545137 hasConceptScore W4362545137C502942594 @default.
- W4362545137 hasConceptScore W4362545137C54355233 @default.
- W4362545137 hasConceptScore W4362545137C55493867 @default.
- W4362545137 hasConceptScore W4362545137C62478195 @default.
- W4362545137 hasConceptScore W4362545137C79266657 @default.
- W4362545137 hasConceptScore W4362545137C86803240 @default.
- W4362545137 hasConceptScore W4362545137C95444343 @default.
- W4362545137 hasConceptScore W4362545137C96232424 @default.
- W4362545137 hasLocation W43625451371 @default.
- W4362545137 hasOpenAccess W4362545137 @default.
- W4362545137 hasPrimaryLocation W43625451371 @default.
- W4362545137 hasRelatedWork W1975426777 @default.
- W4362545137 hasRelatedWork W2019199377 @default.
- W4362545137 hasRelatedWork W2030578167 @default.
- W4362545137 hasRelatedWork W2137628822 @default.
- W4362545137 hasRelatedWork W2163632517 @default.
- W4362545137 hasRelatedWork W2166791066 @default.
- W4362545137 hasRelatedWork W2523852475 @default.
- W4362545137 hasRelatedWork W2584927117 @default.
- W4362545137 hasRelatedWork W2943826953 @default.
- W4362545137 hasRelatedWork W4362414402 @default.
- W4362545137 isParatext "false" @default.
- W4362545137 isRetracted "false" @default.
- W4362545137 workType "article" @default.