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- W4362545278 abstract "<div>Abstract<p>Persistent high-risk HPV infection is considered as a major cause of cervical cancer. Nevertheless, only some infected individuals actually develop cervical cancer. The RIG-I pathway in innate immunity plays an important role in antivirus response. Here, we hypothesized that altered function of mitochondrial antiviral signaling protein (<i>MAVS</i>) and mitochondrial TNF receptor–associated factor 3(<i>TRAF3</i>), key molecules downstream of the viral sensors RIG-I, may impair their ability of clearing HPV and thereby influence the risk for cervical precancerous lesions. To investigate the effects of <i>MAVS</i> and <i>TRAF3</i> polymorphisms on susceptibility to cervical precancerous lesions, 8 SNPs were analyzed in 164 cervical precancerous lesion cases and 428 controls. Gene–environment interactions were also calculated. We found that CA genotype of rs6052130 in <i>MAVS</i> gene were at 1.48 times higher risk of developing cervical precancerous lesion than individuals with CC genotype (CA vs. CC: OR<sub>adjusted</sub> = 1.48, 95% CI, 1.02–2.16). In addition, a significant synergetic interaction between high-risk HPV infection and rs6052130 was found on an additive scale. A significantly decreased risk of cervical precancerous lesions for the TC genotype of rs12435483 in the <i>TRAF3</i> gene (OR<sub>adjusted</sub> = 0.67, 95% CI, 0.45–0.98) was also found. Moreover, MDR analysis identified a significant three-locus interaction model, involving high-risk HPV infection, <i>TRAF3</i> rs12435483 and number of full-term pregnancies. Our results indicate that the <i>MAVS</i> rs6052130 and <i>TRAF3</i> rs12435483 confer genetic susceptibility to cervical precancerous lesions. Moreover, <i>MAVS</i> rs6052130–mutant individuals have an increased vulnerability to high-risk HPV-induced cervical precancerous lesions.</p></div>" @default.
- W4362545278 created "2023-04-06" @default.
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- W4362545278 date "2023-04-03" @default.
- W4362545278 modified "2023-09-26" @default.
- W4362545278 title "Data from Interaction Between Susceptibility Loci in <i>MAVS</i> and <i>TRAF3</i> Genes, and High-risk HPV Infection on the Risk of Cervical Precancerous Lesions in Chinese Population" @default.
- W4362545278 doi "https://doi.org/10.1158/1940-6207.c.6547409.v1" @default.
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